A5014141568- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Cutaneous lymphoproliferative disorders research
- Aldose Reductase and Taurine
- melanin and skin pigmentation
- Skin Protection and Aging
- Asthma and respiratory diseases
- Immune Cell Function and Interaction
- Biochemical Acid Research Studies
- Genomics, phytochemicals, and oxidative stress
- Systemic Sclerosis and Related Diseases
- Immunotherapy and Immune Responses
- Dermatologic Treatments and Research
- T-cell and B-cell Immunology
- Fungal Infections and Studies
- Bone and Joint Diseases
- Urticaria and Related Conditions
- Nail Diseases and Treatments
- Biochemical and Molecular Research
- T-cell and Retrovirus Studies
- Retinoids in leukemia and cellular processes
- Spine and Intervertebral Disc Pathology
- Eicosanoids and Hypertension Pharmacology
Nagoya City University
2016-2025
Mizuho (Japan)
2022
Okazaki City Hospital
2022
Aberrant immune responses to viral pathogens contribute pathogenesis, but our understanding of pathological caused by viruses within the human virome, especially at a population scale, remains limited. We analyzed whole-genome sequencing datasets 6,321 Japanese individuals, including patients with autoimmune diseases (psoriasis vulgaris, rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), pulmonary alveolar proteinosis (PAP) or multiple sclerosis) and coronavirus disease 2019...
Cutaneous T-cell lymphoma (CTCL) is a chronic condition with low malignancy. The combined use of therapeutic agents and photo(chemo)therapy widely applied for the treatment CTCL. efficacy safety bexarotene combination therapy were previously confirmed in Japanese patients was compared monotherapy CTCL.This randomized, open-label, two-parallel-group, active-control specified clinical study diagnosed CTCL carried out over 8 weeks extension conducted at two institutions. This registered Japan...
Ezh2, a well-established epigenetic repressor, can down-regulate leukocyte inflammatory responses, but its role in cutaneous health remains elusive. Here we demonstrate that Ezh2 controls tolerance by regulating Langerhans cell (LC) transmigration across the epidermal basement membrane directly via Talin1 methylation. deficiency impaired disassembly of adhesion structures LCs, leading to their defective integrin-dependent emigration from epidermis and failure induction. Moreover,...
Abstract Phototherapy and apremilast (oral phosphodiesterase‐4 inhibitor) are well‐known in the treatment of moderate to severe psoriasis vulgaris. However, current evidence on efficacy safety their combination is not sufficient. This multicenter, randomized controlled study compared between phototherapy as monotherapy therapy patients with Patients vulgaris were assigned ( n = 29) 13) groups. All underwent an 8‐week regimen comprising irradiation narrowband UV‐B. The group also administered...
Abstract Background Vitiligo presents with varying clinical features based on the type and location. Treatment tends to be more effective face, neck, trunk, mid‐extremities, while lips distal extremities may resistant. in frequently exposed areas such as arms, legs, hands is typically associated a lower Dermatology Life Quality Index. Objectives We aimed identify characteristics potential causes of vitiligo challenging‐to‐treat regions, particular focus hands. Methods analyzed data 337...
Objectives: The aim of the present study was to determine if HLA phenotype is related severe sacroiliitis in Japanese patients with psoriatic arthritis. Methods: This a single-center, retrospective, cross-sectional, observational study. We reviewed clinical information and radiologic examinations arthritis (PsA) who visited our hospital from January 2011 December 2016. Radiographic changes sacroiliac joints were assessed by four independent investigators according recommendations Assessment...
Abstract Ultraviolet (UV)A1 phototherapy is effective for T‐cell‐mediated skin diseases such as atopic dermatitis and mast cell‐mediated mastocytoma. UVA1 also against the sclerotic lesions of systemic sclerosis morphea. Currently, in Japan, access to limited because device has not yet been approved. On basis our experience, we report three patients with localized scleroderma who responded successfully phototherapy. Efficacy was assessed by histological analysis elastography. ameliorated...
Psoriasis is a chronic inflammatory proliferative skin disease involving various types of chemokines regulating immune cell migration, localization, and activation. Bath psoralen plus UVA (PUVA) treatment an established phototherapy for psoriasis, but its effects on chemokine levels remain unknown. We investigated the 22 serum in 20 patients with psoriasis first treated bath PUVA therapy between 2007 2011 single center analyzed associations severity (PASI) before after to investigate...
Abstract Photochemotherapy with psoralen and ultraviolet A (PUVA) is widely used for refractory skin diseases. Bathwater delivery of 8‐methoxypsoralen (8‐MOPS) subsequent UVA irradiation (bath‐PUVA) or oral administration 8‐MOPS to treat mycosis fungoides. We retrospectively analyzed 62 patients fungoides (8 stage IA, 30 IB, 5 IIB, 18 IIIA, 1 IVA2) treated bath‐PUVA at the Dermatology Clinic Nagoya City University Hospital from November 2004 December 2013. complete response was achieved in...
Abstract The principal pathology of psoriasis is impaired skin barrier function, epidermal thickening, and granular layer loss. Exposure to extrinsic factors such as tobacco smoke air pollutants associated with the development psoriasis. Aryl hydrocarbon receptors (AHRs) are activated by act transcriptional regulators. Expression aldo–keto reductase (AKR) 1C3 in spinous regulates keratinocyte differentiation via AHR signaling pathway. We investigated whether single nucleotide polymorphisms...
Dear Editor, Ultraviolet (UV)-A1 was first reported to be an effective treatment for atopic dermatitis in the 1990s,1 and has since been widely applied dermatitis,2 cutaneous T-cell lymphoma, localized systemic scleroderma,3 dyshidrotic palmoplantar eczema.4 UVA1 irradiation is traditionally produced by methyl halogen lamps emitting 340–400-nm wavelengths with three filters. A major drawback of these lamps, however, that they consume large amounts electricity generate unnecessary heat. To...
Topical active vitamin D3 application alone or in combination with topical steroid is widely used to treat psoriasis. In Japan, combined calcipotriol hydrate/betamethasone dipropionate ointment has been for patients psoriasis vulgaris since September 2014. Current evidence regarding the incidence of hypercalcemia due use this product, however, insufficient. We evaluated following severe vulgaris.Japanese (n = 22) extensive plaque (body surface area: 20-30%) applied once daily 8 weeks, and...
Bexarotene is an effective oral drug for the treatment of cutaneous T-cell lymphoma, but careful management required due to its various side effects. In particular, hypertriglyceridemia often requires a reduction or even suspension bexarotene therapy. The risk factors bexarotene-associated severe are not clear. Here, we conducted post hoc analysis data from our previous clinical trial, which confirmed efficacy and safety combined phototherapy, evaluate effect body mass index on...