A5083495533- DNA and Nucleic Acid Chemistry
- Autoimmune Bullous Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Urticaria and Related Conditions
- Advanced biosensing and bioanalysis techniques
- Fungal Infections and Studies
- Spectroscopy and Quantum Chemical Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Metal complexes synthesis and properties
- Advanced Chemical Physics Studies
- Nail Diseases and Treatments
- Analytical Chemistry and Sensors
- Cancer and Skin Lesions
- Antifungal resistance and susceptibility
- Dermatology and Skin Diseases
- Vascular Tumors and Angiosarcomas
- Drug-Induced Adverse Reactions
- Respiratory viral infections research
- Eosinophilic Disorders and Syndromes
- Molecular Junctions and Nanostructures
- Nonmelanoma Skin Cancer Studies
- Immunodeficiency and Autoimmune Disorders
- Quantum chaos and dynamical systems
- Platelet Disorders and Treatments
- Molecular Spectroscopy and Structure
Chiba University
2011-2025
Chiba University Hospital
2019-2024
Massachusetts General Hospital
2024
Harvard University
2024
The University of Tokyo
1997-2012
Osaka University
2009
University of Hyogo
2008-2009
Aberrant immune responses to viral pathogens contribute pathogenesis, but our understanding of pathological caused by viruses within the human virome, especially at a population scale, remains limited. We analyzed whole-genome sequencing datasets 6,321 Japanese individuals, including patients with autoimmune diseases (psoriasis vulgaris, rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), pulmonary alveolar proteinosis (PAP) or multiple sclerosis) and coronavirus disease 2019...
Onychomycosis, a fungal nail infection, is common dermatological condition in Japan, with prevalence of approximately 5%-10%. Despite the introduction new antifungal medications and updated treatment guidelines published 2019, data on real-world prescription trends associated medical costs are limited. This study aimed to investigate patterns topical oral for onychomycosis Japan from fiscal years 2014 2021 using National Database Health Insurance Claims Specific Checkups Open Data. We...
Structural properties, electronic structure and UV absorption spectra of mercury(II) mediated metal–DNA complex, thymine–mercury(II)–thymine base pair (T–HgII–T), were theoretically computationally investigated along with experimental data [Ono et al., J. Am. Chem. Soc., 2006, 128(7), 2172–2173]. The results obtained by density functional theory (DFT) calculations for ground state time-dependent DFT (TD-DFT) excited states associated the polarized continuum model (PCM) in order to account...
Abstract IL-17 plays important roles in host defense against Candida albicans at barrier surfaces and during invasive infection. However, the role of after colonization epidermis, a main site C. infection, remains poorly understood. Using murine model epicutaneous candidiasis without skin abrasion, we found that inflammation triggered by epidermal was self-limiting with fungal clearance completed day 7 inoculation wild-type mice or animals deficient IL-17A IL-17F. In contrast, marked...
The authors have derived coupled equations of motion cumulants that consist a symmetric-ordered product the position and momentum fluctuation operators in one dimension. key point is utilization shift operator acting on potential operator, where expectation value evaluated using cumulant expansion technique. In particular, second-order values are given. resultant expressed by those variables quantal consists an exponential function differential original potential. This procedure enables us...
The reaction mechanism of the reduction dinitrogen coordinated side-on to a binuclear Zr complex, [(eta(5)-C(5)Me(4)H)(2)Zr](2)(mu(2),eta(2),eta(2)-N(2)) (T1), was investigated theoretically using model [(eta(5)-C(5)H(5))(2)Zr](2)(mu(2),eta(2),eta(2)-N(2)) (A1), employing density functional theory calculations. effectiveness A1 in describing T1 confirmed by comparing structures, distributions charge, and frontier molecular orbitals. Our calculations showed that has twisted structure,...
Among skin commensal fungi, lipophilic Malassezia species exist on nearly all human surfaces. The pathophysiology of Malassezia-associated diseases remains poorly understood due in part to the lack appropriate animal models. Our objective was investigate mechanisms underlying Malassezia-induced inflammation using a novel murine model that physiologically recapitulates infection.Mice were inoculated epicutaneously with yeasts without barrier disruption and absence external lipid...
We present a reaction scheme of silver containing 5-substituted uracils (N) bridge formation with two ions to silver-mediated base pair [N-Ag2-N] by using the conductor-like polarizable continuum model (CPCM)-B3LYP/aug-cc-pVDZ level theory. The whole is divided into following three steps: (1) ion binding and deprotonation, (2) transfer, (3) dimer structural fluctuation. With new pKa computing proposed in our previous studies, it found that coordination decreases N 2.5–3.0 units, which an...
Pseudoxanthoma elasticum (PXE) is a disease characterized by aberrant mineralization of soft tissue and fragmentation elastic fibres. It often difficult to distinguish PXE clinically from pseudoxanthoma elasticum‐like papillary dermal elastolysis (PXE‐like PDE). However, we have identified that the dermoscopic findings in include coalescing reticulated yellow‐white clods on light purple‐red background, whereas PXE‐like PDE lack such coloured background. To our knowledge, this first detailed...
Abstract Patients with psoriasis vulgaris have a higher incidence of pemphigoid than the general population. However, there are only few concise reports on coexistence generalized pustular (GPP) and pemphigoid. The authors describe rare case simultaneous development GPP multiple autoantibodies (i.e., BP180–C‐terminal, 200‐kDa protein, laminin 332 proteins) in complete responder immune checkpoint inhibitor (ICI) treatment for lung cancer. Anti–interleukin 17 inhibitors oral corticosteroids at...
Infants hospitalized for bronchiolitis are at high risk developing recurrent wheeze in childhood. The role of airway lipids the link between these two conditions remains unclear. This study aimed to identify association infants and development wheeze, with a focus on immunoglobulin E (IgE) sensitization.
In order to investigate static quantum isotope effects on the stability of proton-transferred structures, we defined an effective quantal potential energy hypersurface (EQPES), which includes mass-dependent effects. We demonstrated difference between ordinary surface and EQPES double well as a simple example. The minimum path describes zero-point energy-corrected structures tunneling motion, is characterized classically forbidden motion. also performed analysis model proton-transfer...
Proliferating trichilemmal tumour (PTT) is a rare and usually benign dermal or subcutaneous neoplasm. Some PTTs are difficult to clinically diagnose since the clinical differential diagnoses of PTT range from conditions, such as epidermal cyst, malignant skin tumours, basal cell carcinoma (BCC), squamous (SCC), [1-3]. The lack distinguishing dermoscopic sonographic characteristics reported in literature prompted us report case [...]
In order to investigate an origin of structural stability a copper ion containing artificial DNA, we evaluated the stacking energy between [H−Cu2+−H] (H: hydroxypyridone) dimer by means density functional theory (DFT) with Anderson−Langreth−Lindqvist van der Waals (vdW) functional. The calculated distance ions is about 3.6 Å, which agrees well experimental data. Evaluated 8−10 kcal/mol, slightly smaller than that two base pairs in natural B-DNA. This tendency does not change [H−2H+−H],...
We evaluated the stability, UV−vis spectra, and possibility of stacking [S−M(II)−S] (M = Ni, Pd, Pt, S: hydroxypyridinethione) using density functional theory (DFT). calculated formation energies modified bases with possible combinations chalcogen atoms metal cations. The results confirmed that [H−Ni(II)−H] (H: hydroxypyridone), [H−Cu(II)−H], [S−Cu(II)−S] would form stable metal−base pairing; on other hand, [H−Zn(II)−H], [S−Zn(II)−S], [H−Pt(II)−H] not. predicted excitations at 400−410 nm,...