A5062694754- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Neonatal Respiratory Health Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Phagocytosis and Immune Regulation
- Medical Imaging and Pathology Studies
- Tuberculosis Research and Epidemiology
- Congenital Diaphragmatic Hernia Studies
- Influenza Virus Research Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Erythrocyte Function and Pathophysiology
- Tracheal and airway disorders
- Immune cells in cancer
- Bacterial Infections and Vaccines
- COVID-19 epidemiological studies
- Mycobacterium research and diagnosis
- Emergency and Acute Care Studies
- Viral gastroenteritis research and epidemiology
- Inhalation and Respiratory Drug Delivery
- SARS-CoV-2 and COVID-19 Research
- Nosocomial Infections in ICU
- Dysphagia Assessment and Management
- Endoplasmic Reticulum Stress and Disease
- Immune Cell Function and Interaction
- Transplantation: Methods and Outcomes
Nagasaki University
2016-2025
Nagasaki Ajisai Hospital
2020-2023
Tohoku University
2020-2021
Niigata University
2020-2021
Nagasaki University Hospital
2012-2021
Japan International Cooperation Agency
2020-2021
Hokkaido University
2020-2021
National Center for Global Health and Medicine
2020-2021
National Institute of Infectious Diseases
2020-2021
Suzuki (Japan)
2020-2021
Abstract We analyzed 3,184 cases of coronavirus disease in Japan and identified 61 case-clusters healthcare other care facilities, restaurants bars, workplaces, music events. also 22 probable primary case-patients for the clusters; most were 20–39 years age presymptomatic or asymptomatic at virus transmission.
Background The increasing burden of pneumonia in adults is an emerging health issue the era global population aging. This study was conducted to elucidate community-onset (COP) and its etiologic fractions Japan, world's most aged society. Methods A multicenter prospective surveillance for COP from September 2011 January 2013 Japan. All patients ≥15 years, including those with community-acquired (CAP) care-associated (HCAP), were enrolled at four community hospitals on major islands....
Inhaled granulocyte/macrophage-colony stimulating factor (GM-CSF) is a promising therapy for pulmonary alveolar proteinosis (PAP) but has not been adequately studied.To evaluate safety and efficacy of inhaled GM-CSF in patients with unremitting or progressive PAP.We conducted national, multicenter, self-controlled, phase II trial at nine centers throughout Japan. Patients who had lung biopsy cytology findings diagnostic PAP, an elevated serum antibody level, Pa(O(2)) less than 75 mm Hg...
Abstract Statins are potent, cholesterol-lowering agents with newly appreciated, broad anti-inflammatory properties, largely based upon their ability to block the prenylation of Rho GTPases, including RhoA. Because phagocytosis apoptotic cells (efferocytosis) is a pivotal regulator inflammation, which inhibited by RhoA, we sought determine whether statins enhanced efferocytosis. The effect lovastatin on efferocytosis was investigated in primary human macrophages, murine lung, and alveolar...
The interplay between nasopharyngeal bacterial carriage, viral coinfection, and lower respiratory tract infections (LRTIs) is poorly understood. We explored this association in Vietnamese children aged less than 5 years.A hospital-based case-control study of pediatric LRTIs was conducted Nha Trang, Vietnam. A total 550 hospitalized (274 radiologically confirmed pneumonia [RCP] 276 other LRTIs) were enrolled 350 healthy controls randomly selected from the community. Polymerase chain...
The mammalian ATP-binding cassette transporters A1 and A7 (ABCA1 -A7) show sequence similarity to CED-7, a Caenorhabditis elegans gene that mediates the clearance of apoptotic cells. Using RNA interference or targeting, we knock down macrophage ABCA7 but not -A1 results in defective engulfment In response cells, moves cell surface colocalizes with low-density lipoprotein receptor-related protein 1 (LRP1) phagocytic cups. localization LRP1 is ABCA7-deficient C1q an opsonin cells acts via...
Rationale: Efficient removal of apoptotic cells is essential for the resolution acute pulmonary inflammation. Alveolar macrophages ingest less avidly than other professional phagocytes at rest but overcome this defect during Surfactant protein (SP)-A and SP-D are potent modulators macrophage function may suppress clearance through activation transmembrane receptor signal inhibitory regulatory α (SIRPα).Objectives: To investigate whether binding SP-A to SIRPα on alveolar suppresses cell...
Cigarette smoke (CS) is the primary cause of chronic obstructive pulmonary disease (COPD), an effect that is, in part, due to intense oxidant stress. Clearance apoptotic cells (efferocytosis) a critical regulator lung homeostasis, which defective smokers and patients with COPD, suggesting role pathogenesis.
Pulmonary alveolar proteinosis is a disease characterized by abnormal accumulation of surfactant in the alveoli. Most cases are autoimmune and associated with an autoantibody against granulocyte–macrophage colony-stimulating factor (GM-CSF) that prevents clearing pulmonary macrophages. An open-label, phase 2 study showed some therapeutic efficacy inhaled recombinant human GM-CSF patients severe proteinosis; however, mild-to-moderate remains unclear.
Aberrant immune responses to viral pathogens contribute pathogenesis, but our understanding of pathological caused by viruses within the human virome, especially at a population scale, remains limited. We analyzed whole-genome sequencing datasets 6,321 Japanese individuals, including patients with autoimmune diseases (psoriasis vulgaris, rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), pulmonary alveolar proteinosis (PAP) or multiple sclerosis) and coronavirus disease 2019...
<h3>Background</h3> Disruption of granulocyte/macrophage colony-stimulating factor (GM-CSF) signalling causes pulmonary alveolar proteinosis (PAP). Rarely, genetic defects in neonatal or infant-onset PAP have been identified <i>CSF2RA</i>. However, no report has clearly any function-associated defect <i>CSF2RB</i>. <h3>Methods and results</h3> The patient was diagnosed with at the age 36 developed respiratory failure. She negative for GM-CSF autoantibody had underlying disease. Signalling...
Background: Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory infection in children less than 5 years age. The impact non-RSV coinfection on the severity RSV disease unknown. Methods: This hospital-based prospective study was conducted Nagasaki, Japan, all age with (ARI) who had undergone rapid diagnostic test between April 2009 and March 2010. Thirteen viruses were identified from nasopharyngeal swab samples using multiplex polymerase chain reaction;...
Comprehensive population-based data on the role of respiratory viruses in development lower tract infections (LRTIs) remain unclear. We investigated incidence and effect single multiple with risk LRTIs Vietnam. Population-based prospective surveillance a case-control study hospitalised paediatric patients acute infection (ARI) were conducted from April 2007 through to March 2010. Healthy controls randomly recruited same community. Nasopharyngeal samples collected tested for 13 using...
Several mutations in the surfactant protein C (SP-C) gene (<i>SFTPC</i>) have been reported as causing familial pulmonary fibrosis (FPF). However, genetic background and clinical features of FPF are still not fully understood. We identified one Japanese kindred, which at least six individuals over three generations were diagnosed with fibrosis. examined patients radiologically histopathologically sequenced their <i>SFTPC</i> <i>ABCA3</i> genes. also established a cell line stably expressing...
Abstract Pulmonary alveolar proteinosis (PAP) is a devastating lung disease caused by abnormal surfactant homeostasis, with prevalence of 6–7 cases per million population worldwide. While mutations causing hereditary PAP have been reported, the genetic basis contributing to autoimmune (aPAP) has not thoroughly investigated. Here, we conducted genome-wide association study aPAP in 198 patients and 395 control participants Japanese ancestry. The common variant, rs138024423 at 6p21,...
<h3>Background</h3> On 11 March 2011, the Tohoku earthquake and tsunami struck off coast of northeastern Japan. Within 3 weeks, an increased number pneumonia admissions deaths occurred in local hospitals. <h3>Methods</h3> A multicentre survey was conducted at three hospitals Kesennuma City (population 74 000), northern Miyagi Prefecture. All adults aged ≥18 years hospitalised between 2010 June 2011 with community-acquired were identified using hospital databases medical records. Segmented...
Earlier work showed that apoptosis of alveolar epithelial cells (AECs) in response to endogenous or xenobiotic factors is regulated by autocrine generation angiotensin (ANG) II and its counterregulatory peptide ANG1-7. Mutations surfactant protein C (SP-C) induce endoplasmic reticulum (ER) stress AECs cause lung fibrosis. This study tested the hypothesis ER stress-induced might also be ANGII/ANG1-7 system AECs. was induced A549 primary cultures human with proteasome inhibitor MG132 SP-C...
Various viruses are known to be associated with pneumonia. However, the impact of viral infections on adult pneumonia mortality remains unclear. This study aimed clarify effect virus infection among adults stratified by type and patient comorbidities.This multicentre prospective enrolled patients aged ≥15 years from September 2011 August 2014. Sputum samples were tested in-house multiplex polymerase chain reaction assays identify 13 respiratory viruses. Viral status its in-hospital examined...
Serotype-specific quantification data are essential for elucidating the complex epidemiology of Streptococcus pneumoniae and evaluating pneumococcal vaccine efficacy. Various PCR-based assays have been developed to circumvent drawback labour-intensive time-consuming culture-based procedures serotype determination pneumococcus. Here, we applied a nanofluidic real-time PCR system establish novel assay. Twenty-nine primer pairs, 13 which were newly designed, selected assay cover 50 serotypes...
The overall coronavirus disease secondary attack rate (SAR) in family members was 19.0% 10 prefectures of Japan during February 22-May 31, 2020. SAR lower for primary cases diagnosed early, within 2 days after symptom onset. asymptomatic 11.8%.