A5068813933- Quantum, superfluid, helium dynamics
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Atomic and Subatomic Physics Research
- Physics of Superconductivity and Magnetism
- Asthma and respiratory diseases
- Cold Atom Physics and Bose-Einstein Condensates
- Respiratory Support and Mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pulmonary Hypertension Research and Treatments
- Enzyme Production and Characterization
- Neonatal Respiratory Health Research
- Microbial Metabolic Engineering and Bioproduction
- ZnO doping and properties
- High-pressure geophysics and materials
- Mechanical and Optical Resonators
- Nuclear physics research studies
- Methane Hydrates and Related Phenomena
- Biofuel production and bioconversion
- Magnetic and transport properties of perovskites and related materials
- Force Microscopy Techniques and Applications
- Respiratory and Cough-Related Research
- Laser-Matter Interactions and Applications
- Spectroscopy and Quantum Chemical Studies
- Advanced Fiber Laser Technologies
- Medical Imaging and Pathology Studies
Hokkaido University
2015-2024
National Institute for Materials Science
2022-2024
University of Electro-Communications
2013-2023
Yamagata University
2023
Asahi Kasei (Japan)
2019-2022
Yamagata University Hospital
2021-2022
Kanto Central Hospital
2002-2022
Hitachi (Japan)
2022
Nara Medical University
2022
Tokyo Metropolitan Geriatric Hospital
2022
The major sites of obstruction in chronic obstructive pulmonary disease (COPD) are small airways (<2 mm diameter). We wanted to determine whether there was a relationship between small-airway and emphysematous destruction COPD.We used multidetector computed tomography (CT) compare the number measuring 2.0 2.5 78 patients who had various stages COPD, as judged by scoring on Global Initiative for Chronic Obstructive Lung Disease (GOLD) scale, isolated lungs removed from with COPD underwent...
The relatively sparse but diverse microbiome in human lungs may become less chronic obstructive pulmonary disease (COPD). This article examines the relationship of this to emphysematous tissue destruction, number terminal bronchioles, infiltrating inflammatory cells, and host gene expression.Culture-independent pyrosequencing analysis was used examine V3-V5 regions bacterial 16S ribosomal DNA 40 samples lung from 5 patients with COPD (Global Initiative for Chronic Obstructive Lung Disease...
Pulmonary macrophages are one of the sources various antioxidant and detoxification enzymes for which NF-E2-related factor 2 (Nrf2) is a key transcriptional factor. Although Nrf2 deficiency reportedly induces severe emphysema in mice exposed to cigarette smoke (CS), no reports have studied regulation chronic obstructive pulmonary disease (COPD). In this study, activation response CS was evaluated human alveolar macrophages, age-related differences CS-induced mouse were determined....
A rat T cell line of the "helper" phenotype (W3/25-positive, OX 8-negative) has been derived from Lewis rats inoculated with P2 protein isolated bovine PNS myelin. The LiP2/A is exquisitely specific for protein, exhibiting no reactivity to basic or PPD. In addition responding strongly intact cells show some response a synthetic peptide containing neuritogenic amino acid sequence (SP-B, residues 66-78). Intravenous inoculation naive as few 10(4) activated leads onset mild clinical signs...
Ultrasonic examinations conducted in order to diagnose the depth of invasion and local lymph node metastases rectal cancer. The intrarectal approach was performed preoperatively 99 patients with cancer, using either an Olympus-Aloka ultrasonic endoscopeTM (7.5 MHz) or other probes (Aloka, 7.5 MHz, 5 MHz). Through this method, intrapelvic organs were detected clearly, hypoechoic findings due tumors all patients. normal wall echogenically divided into five layers, third layer being submucosal...
Some patients with chronic obstructive pulmonary disease (COPD) have asthma-like features, such as significant bronchodilator reversibility, blood eosinophilia, and/or atopy, even if they are not clinically diagnosed having asthma. However, the clinical significance of features overlapping COPD remains unclear.The aim this study was to assess effect on course who were adequately treated and followed-up over 10 years.A total 268 had been considered asthma by respiratory specialists included...
Pulmonary alveolar proteinosis is a disease characterized by abnormal accumulation of surfactant in the alveoli. Most cases are autoimmune and associated with an autoantibody against granulocyte–macrophage colony-stimulating factor (GM-CSF) that prevents clearing pulmonary macrophages. An open-label, phase 2 study showed some therapeutic efficacy inhaled recombinant human GM-CSF patients severe proteinosis; however, mild-to-moderate remains unclear.
Chronic obstructive pulmonary disease (COPD) is a heterogeneous consisting of emphysema, small airway obstruction, and/or chronic bronchitis that results in significant loss lung function over time. In order to gain insights into the molecular pathways underlying progression emphysema and explore computational strategies for identifying COPD therapeutics, we profiled gene expression tissue samples obtained from regions within same with varying amounts emphysematous destruction smokers (8 × 8...
Exacerbations are among the major factors that may affect natural history of chronic obstructive pulmonary disease (COPD). The aim was to investigate clinical characteristics and determinants COPD exacerbations in our 5-year observational cohort study which had a very low exacerbation frequency. A total 279 patients with participated Hokkaido study, 268 subjects who data for multiple visits were analysed. Exacerbation defined ways: patient’s subjective complaint, symptom definition,...
Curcumin, a yellow pigment obtained from turmeric (Curcumina longa), is dietary polyphenol that has been reported to possess anti-inflammatory and antioxidant properties. The effect of curcumin against the development pulmonary emphysema in animal models unknown. aim this study was determine whether able attenuate mice. Nine-week-old male C57BL/6J mice were treated with intratracheal porcine pancreatic elastase (PPE) or exposed mainstream cigarette smoke (CS) (60 min/day for 10 consecutive...
Archaebacterial Sulfolobus acidocaldarius geranylgeranyl-diphosphate (GGPP) synthase (EC 2.5.1.29) catalyzes consecutive condensations of isopentenyl diphosphate with allylic diphosphates to produce GGPP which is the important precursor archaebacterial ether-linked lipids. We developed an expression screening method for cloning gene, utilizes carotenoid biosynthesis genes Erwinia uredovora visualize a clone expressing synthase, and then screened genomic DNA library from S. gene by using this...
We show through the experiments of parametric anti-Stokes stimulated Raman scattering for solid hydrogen that phase matching in a process can be self-induced without stringent restriction medium. explain this as consequence strong coupling between radiation fields and medium spontaneously established process.
The electric quadrupole transition from the first 2(+) state to ground 0(+) in 16C is studied through measurement of lifetime by a recoil shadow method applied inelastically scattered radioactive nuclei. measured mean 77+/-14(stat)+/-19(syst) ps. central value corresponds B(E2;2+(1)-->0(+)) 0.63e(2) fm(4), or 0.26 Weisskopf units. strength found be anomalously small compared empirically predicted value.
Hydrothermal ZnO nanowires have shown great potential for various nanoscale device applications due to their fascinating properties and low-temperature processing. A preferential crystal growth of (0001) polar plane is essential fundamental realize the anisotropic nanowire growth. Here we demonstrate that a critical concentration nucleation strongly depends on plane, which plays an important role hydrothermal nanowires. We measure rate each when varying Zn ionic species by using regular...
The introduction of microCT has made it possible to show that the terminal bronchioles are narrowed and destroyed before onset emphysematous destruction in COPD. This report extends those observations cellular molecular level centrilobular phenotype lungs donated by persons with very severe COPD (n = 4) treated lung transplantation unused donor serving as controls. These specimens provided companion samples previously examined 61) we using quantitative histology gene expression profiling...
Very little is known about airways that are too small to be visible on thoracic multidetector computed tomography but larger than the terminal bronchioles.To examine structure of preterminal bronchioles located one generation proximal in centrilobular and panlobular emphysema.Preterminal were identified by backtracking from bronchioles, their centerlines established along entire length lumens. Multiple cross-sectional images perpendicular centerline reconstructed evaluate bronchiolar wall...
Metal oxide nanowires hold great promise for various device applications due to their unique and robust physical properties in air and/or water also abundance on Earth. Vapor-liquid-solid (VLS) growth of metal offers the high controllability diameters spatial positions. In addition, VLS has applicability axial radial heterostructures, which are not attainable by other nanowire methods. However, material species available substantially limited even though variety species, fascinating...
Rationale: Sirolimus has been shown in a randomized, controlled clinical trial to stabilize lung function patients with lymphangioleiomyomatosis (LAM) treated for 12-month time period; however the pretreatment decline after drug was discontinued indicated that continued exposure is required suppress disease progression.Objectives: To elucidate durability and tolerability of long-term sirolimus treatment Asian LAM.Methods: We conducted single-arm, open-label, investigator-initiated safety...