A5087089455- Streptococcal Infections and Treatments
- Infective Endocarditis Diagnosis and Management
- Cardiac Imaging and Diagnostics
- Medical Imaging and Pathology Studies
- COVID-19 Clinical Research Studies
- Medical Imaging Techniques and Applications
- Botulinum Toxin and Related Neurological Disorders
- RNA and protein synthesis mechanisms
- Pulmonary Hypertension Research and Treatments
- Tuberculosis Research and Epidemiology
- Neonatal Respiratory Health Research
- Mycobacterium research and diagnosis
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Phagocytosis and Immune Regulation
- Liver Disease Diagnosis and Treatment
- SARS-CoV-2 detection and testing
- SARS-CoV-2 and COVID-19 Research
- Intensive Care Unit Cognitive Disorders
- Intraocular Surgery and Lenses
- COVID-19 epidemiological studies
- Tracheal and airway disorders
- Emergency and Acute Care Studies
- Antifungal resistance and susceptibility
- Cell Adhesion Molecules Research
Nagasaki University Hospital
2016-2025
Nagasaki University
2010-2024
Osaka Women's and Children's Hospital
2022
Nagasaki Municipal Hospital
2021
Suzuki (Japan)
2021
National Institute of Infectious Diseases
2001-2021
Brigham and Women's Hospital
2021
Fukushima Medical University
2021
Saiseikai Niigata Daini Hospital
2020
Yamagata Prefectural Police
2019
Pulmonary alveolar proteinosis is a disease characterized by abnormal accumulation of surfactant in the alveoli. Most cases are autoimmune and associated with an autoantibody against granulocyte–macrophage colony-stimulating factor (GM-CSF) that prevents clearing pulmonary macrophages. An open-label, phase 2 study showed some therapeutic efficacy inhaled recombinant human GM-CSF patients severe proteinosis; however, mild-to-moderate remains unclear.
To identify genes related to normal-pressure hydrocephalus (NPH) in one Japanese family with several members NPH.We performed whole-exome sequencing (WES) on a multiple individuals NPH and identified candidate gene. Then we generated knockout mouse using CRISPR/Cas9 confirm the effect of gene pathogenesis hydrocephalus.In WES, loss-of-function variant CFAP43 that segregated disease. encoding cilia- flagella-associated protein is preferentially expressed testis. Recent studies have revealed...
The pathogenic mechanisms underlying pulmonary arterial hypertension resulting from schistosomiasis, one of the most common causes worldwide, remain unknown. We hypothesized that transforming growth factor-β (TGF-β) signaling as a consequence Th2 inflammation is critical for pathogenesis this disease.Mice sensitized and subsequently challenged with Schistosoma mansoni eggs developed associated an increase in right ventricular systolic pressure, thickening artery media, hypertrophy....
Objectives The accurate detection of severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) is essential for the diagnosis coronavirus disease 2019 (COVID-19). We compared quantitative RT-PCR results between nasopharyngeal swabs and saliva specimens. Methods A COVID-19 outbreak occurred on a cruise ship at Nagasaki port, Japan. obtained 123 each from asymptomatic or mild patients in late phase infection. Results intervals to sampling were 25.5 days 28.9 saliva. positive rate was 19.5%...
Insufficient glucocorticoid (GC) signaling is frequently observed in major depressive disorder (MDD). Since emotional and behavioral symptoms are often accompanied by disturbances hypothalamic systems, GC insufficiency this region regarded as important the pathogenesis of MDD. In study, 22 early GC-responsive genes comprising 15 up-regulated 7 down-regulated rat hypothalamus were identified being regulated at least two-fold dexamethasone using microarray with 599 unique transcripts. Among...
Raman spectra of charcoal fragments in cumulative soils central Japan, where grasslands have been sustained using intentional burning for ~ 1000 years, were obtained and compared to those fresh after modern grass clarify their disappearance alteration process the soils. Although values each Raman-spectrum parameter soil are partially similar, certain differences indicating or observed. Charcoal with lower graphitization altered chemically age at decadal century scale, suggested by changes...
Abstract Background Cryptococcal meningitis (CM) is an invasive fungal infection with a poor prognosis that often occurs in both healthy individuals and compromised hosts, such as patients infected human immunodeficiency virus (HIV). Unlike CM HIV patients, evidence regarding non‐HIV limited to small retrospective studies. Objective To identify the pretreatment prognostic factors for patients. Methods We conducted large analysis of using data from nationwide Japanese database. The study...
Asthma, a common, chronic lung disease in industrialized countries, is characterized by the production of large quantities IgE antibody B cells and decrease IFN-γ/IL-4 (Th1/Th2) ratio. Gyokuheifusan (GHS) classical formulation traditional Chinese medicine (TCM) that usually prescribed to prevent or treat respiratory tract diseases, such as infection bronchial asthma. In order evaluate possible effectiveness GHS on asthma, its immunomodulatory activity was examined ovalbumin (OVA)-induced...
Hereditary pulmonary alveolar proteinosis (PAP) caused by mutations in CSF2RA or CSF2RB, which encode GM-CSF receptor α and β respectively, is a rare disease. Although some experimental therapeutic strategies have been proposed, no clinical evidence has yet reported. We herein describe the course recurrence of hereditary PAP after lung transplantation. A 36-year-old woman developed unknown etiology. She underwent bilateral transplantation from living donors at age 42 years because severe...
Efficient clearance of apoptotic cells from the lung by alveolar macrophages is important for maintenance tissue structure and function. Lung humans with emphysema contains increased numbers decreased levels vascular endothelial growth factor (VEGF). Mice treated VEGF receptor inhibitors have develop emphysema. We hypothesized that regulates cell (AM) via its interaction 1 (VEGF R1). Our data show uptake murine AMs human monocyte-derived inhibited depletion activates Rac1. Antibody blockade...
Abstract Impaired efferocytosis is a key mechanism of inflammatory lung diseases, including chronic obstructive pulmonary disease and cystic fibrosis. Cigarette smoking activates RhoA impairs in alveolar macrophages, but the has not been fully elucidated. We investigated role endoplasmic reticulum (ER) stress induced by cigarette disruption efferocytosis. Both tunicamycin (10 μg/ml) thapsigargin (0.1 1 μM), which are ER inducers, suppressed J774 cells, Rho-associated coiled-coil-forming...
The relationship between the genetic polymorphism of S-mephenytoin 4'-hydroxylation catalyzed by CYP2C19 and N-demethylation imipramine was examined in 10 Japanese depressed patients. Five patients, who were poor metabolizers S-mephenytoin, determined to be either homozygous for a mutation exon 5 or heterozygous mutations 4 gene. In contrast, five extensive metabolizers, had no mutations. demethylation index (the desipramine/imipramine ratio) significantly lower patients with defects. Plasma...
Abstract To develop cell therapies for ischemic diseases, endothelial progenitor cells (EPCs) have been expected to play a pivotal role in vascular regeneration. It is desirable use molecular marker that related the function of cells. Here, quantitative polymerase chain reaction array revealed early EPCs derived from CD133+ exhibited significant expression MMP-9. Some populations expressed MMP-9 on surface and others did not. We also attempted separate proangiogenic fraction using functional...
Since the introduction of angiogenic cell therapy using early endothelial progenitor cells (EPCs), myeloid (MACs) have been expected to be useful in treating ischemic diseases. In order elucidate properties MACs/EPCs, we clarified characteristics MACs as compared M2 macrophages (Mϕs). Comparison gene expression profiles and late EPCs revealed that expressed greater amounts metalloproteinase (MMP)-9. It should noted profile MMP-2/9 on surface was similar Mϕs, might an active form based...
Abstract Although Streptococcus suis has attracted public attention as a major swine and human pathogen, this bacterium also been isolated from other animals, including ruminants. However, recent taxonomic studies revealed the existence of species that were previously identified S. , some these isolates reclassified novel ruminantium . In Japan, biochemically is frequently diseased ruminants; however, such have not yet accurately, their aetiological importance in ruminants unclear....