A5088410041- Parasites and Host Interactions
- Pulmonary Hypertension Research and Treatments
- Helminth infection and control
- Parasite Biology and Host Interactions
- Liver Disease and Transplantation
- Parasitic infections in humans and animals
- Cytokine Signaling Pathways and Interactions
- Liver Disease Diagnosis and Treatment
- Vascular Anomalies and Treatments
- Cardiovascular Issues in Pregnancy
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Macrophage Migration Inhibitory Factor
- Global Health and Epidemiology
Universidade de Pernambuco
2011-2023
Pulmonary Vascular Research Institute
2013
National Institute of Allergy and Infectious Diseases
2013
National Institutes of Health
2013
University of Kent
2013
University of Pittsburgh
2013
Universidade Federal de Pernambuco
2010
Abstract Pulmonary arterial hypertension (PAH) is an obstructive disease of the precapillary pulmonary arteries. Schistosomiasis-associated PAH shares altered vascular TGF-β signalling with idiopathic, heritable and autoimmune-associated etiologies; moreover, blockade can prevent experimental (PH) in pre-clinical models. regulated at level activation, but how activated this unknown. Here we show activation by thrombospondin-1 (TSP-1) both required sufficient for development PH Schistosoma...
The pathogenic mechanisms underlying pulmonary arterial hypertension resulting from schistosomiasis, one of the most common causes worldwide, remain unknown. We hypothesized that transforming growth factor-β (TGF-β) signaling as a consequence Th2 inflammation is critical for pathogenesis this disease.Mice sensitized and subsequently challenged with Schistosoma mansoni eggs developed associated an increase in right ventricular systolic pressure, thickening artery media, hypertrophy....
The etiology of schistosomiasis-associated pulmonary arterial hypertension (PAH), a major cause PAH worldwide, is poorly understood. Schistosoma mansoni exposure results in prototypical type-2 inflammation. Furthermore, transforming growth factor (TGF)-β signaling required for experimental (PH) caused by exposure. We hypothesized inflammation driven IL-4 and IL-13 necessary Schistosoma-induced TGF-β-dependent vascular remodeling. Wild-type, IL-4(-/-), IL-13(-/-), IL-4(-/-)IL-13(-/-) mice...
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Schistosomiasis‐associated pulmonary arterial hypertension (PAH) is one of the most common causes worldwide. A potential contributing mechanism to pathogenesis this disease a localized immune reaction retained and persistent parasite‐derived antigens. We sought identify Schistosoma‐derived egg antigens present in lungs individuals who died disease. obtained 18 lung samples collected at autopsy from schistosomiasis‐associated PAH Brazil. rabbit polyclonal antibody was created known...
Abstract Background: Pulmonary hypertension (PH) can occur as a complication of schistosomiasis. In humans, schistosomiasis-PH persists despite antihelminthic therapy and parasite eradication. We hypothesized that persistent disease arises consequence exposure repetition. Methods: Following intraperitoneal sensitization, mice were experimentally exposed to Schistosoma eggs by intravenous injection, either once or three times repeatedly. The phenotype was characterized right heart...
Schistosomiasis-associated pulmonary arterial hypertension (SPAH) is a major concern worldwide. However, the role of gender-specific contributing factors in SPAH unknown.We investigated how systolic artery pressure (SPAP) values and presence severe SPAP relate to gender, menopausal status, pregnancy history patients.Seventy-nine patients diagnosed with from 2000 2009 were assessed 66 enrolled study. Information about age, pregnancy, echocardiography-derived SPAP, invasive mean (mPAP) was...
Introduction: Hepatosplenic schistosomiasis mansoni, associated with pulmonary arterial hypertension (PAH), causes cardiac chamber remodeling.Little is known about its long-term evolution.Objective: To evaluate the alterations caused by PAH in patients and analyze clinical echocardiographic evolution over a period of 10 years.Methods: The study included 60 due to 50 healthy control patients.Clinical data were evaluated, including dimensions, parietal thickness, function right left chambers,...
Introdução: A esquistossomose mansoni hepatoesplênica, associada com hipertensão arterial pulmonar (HAP), provoca remodelamento das câmaras cardíacas. Sua evolução a longo prazo é pouco conhecida. Objetivo: Avaliar as alterações provocadas pela HAP em pacientes e analisar clínica ecocardiográfica por um período de 10 anos. Métodos: Foram estudados 60 50 indivíduos controle sadios. Avaliaram-se dados clínicos ecocardiográficos como dimensões, espessura parietal função direitas esquerdas...
Introduction: Schistosomiasis is a tropical parasitic disease may cause severe pulmonary hypertension (SIPH), which leads to right ventricular (RV) remodeling and dysfunction, can be detected by decreased tricuspid annular plane systolic excursion (TAPSE) variation of RV areas.In normal RV, rich in longitudinal fibers, strain prevails, transverse smaller.Objective: To assess, using conventional echocardiography two-dimensional strain, patients with SIPH, comparing the results clinical...