A5065609114- Pulmonary Hypertension Research and Treatments
- Receptor Mechanisms and Signaling
- Pharmacological Effects and Assays
- Ion channel regulation and function
- Cardiovascular Function and Risk Factors
- Intracranial Aneurysms: Treatment and Complications
- Acute Ischemic Stroke Management
- COVID-19 Clinical Research Studies
- Neuropeptides and Animal Physiology
- Long-Term Effects of COVID-19
- Cerebrovascular and Carotid Artery Diseases
- Hepatitis C virus research
- Nicotinic Acetylcholine Receptors Study
- Cardiovascular Disease and Adiposity
- Adipose Tissue and Metabolism
- Congenital Heart Disease Studies
- Cardiac Fibrosis and Remodeling
- Neonatal Respiratory Health Research
- Extracellular vesicles in disease
- Intracerebral and Subarachnoid Hemorrhage Research
- RNA modifications and cancer
- High Altitude and Hypoxia
- SARS-CoV-2 and COVID-19 Research
- Vascular Malformations Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
Mayo Clinic
1994-2024
University of Colorado Denver
2012-2024
Mid Cheshire Hospitals NHS Foundation Trust
2024
Manchester University NHS Foundation Trust
2024
Aintree University Hospitals NHS Foundation Trust
2024
University of Liverpool
2024
University of Oxford
2024
University of Colorado Anschutz Medical Campus
2004-2023
Public Health Scotland
2021
National Health and Medical Research Council
2021
Adjusted-dose warfarin is highly efficacious for prevention of ischaemic stroke in patients with atrial fibrillation (AF). However, this treatment carries a risk bleeding and the need frequent medical monitoring. We sought an alternative that would be safer easier to administer AF who are at high-risk thromboembolism.1044 least one thromboembolic factor (congestive heart failure or left ventricular fractional shortening < = 25%, previous thromboembolism, systolic blood pressure more than 160...
In Brief Objective: To investigate the mortality associated with cardiovascular diseases and effect of estrogen treatment in women who underwent unilateral or bilateral oophorectomy before menopause. Design: We conducted a cohort study long-term follow-up Olmsted County, MN, either onset menopause from 1950 through 1987. Each member was matched by age to referent woman same population had not undergone any oophorectomy. studied disease total 1,274 oophorectomy, 1,091 2,383 women. Results:...
During February 26–April 1, 2020, community mobility (a proxy measure for social distancing) in the metropolitan areas of San Francisco, Seattle, New Orleans, and York City declined, decreasing ..
We used the Mayo Clinic medical records linkage system to detect all cases of intracranial vascular malformation (IVM) among residents Olmsted County, Minnesota from 1965 1992 and found 48 IVMs over 27-year period, including four patients with IVM detected at autopsy, without prior symptoms. Twenty-nine were symptomatic presentation. From 1985 1992, age- sex-adjusted detection rate for excluding asymptomatic autopsy was 2.75 in 100,000 person-years (P-Y) (95% CI, 1.6 3.9). 1.84 P-Y 1.3 2.4)....
<h3>Objective:</h3> White matter hyperintensity (WMH) may be a marker of an underlying cerebral microangiopathy. Therefore, we hypothesized that WMH would most severe in patients with lacunar stroke and intracerebral hemorrhage (ICH), 2 types which small vessel (SV) changes are pathophysiologically relevant. <h3>Methods:</h3> We determined volume (WMHV) cohorts prospectively ascertained acute ischemic (AIS) (Massachusetts General Hospital [MGH], n = 628, the Ischemic Stroke Genetics Study...
Abstract Pulmonary arterial hypertension (PAH) is an obstructive disease of the precapillary pulmonary arteries. Schistosomiasis-associated PAH shares altered vascular TGF-β signalling with idiopathic, heritable and autoimmune-associated etiologies; moreover, blockade can prevent experimental (PH) in pre-clinical models. regulated at level activation, but how activated this unknown. Here we show activation by thrombospondin-1 (TSP-1) both required sufficient for development PH Schistosoma...
Most published studies addressing the role of hypoxia inducible factors (HIFs) in hypoxia-induced pulmonary hypertension development employ models that may not recapitulate clinical setting, including use animals with pre-existing lung/vascular defects secondary to embryonic HIF ablation or activation. Furthermore, critical questions how and when signalling contributes remain unanswered.Normal adult rodents which global HIF1 HIF2 was inhibited by gene deletion pharmacological inhibition...
Fibrotic disorders account for over one third of mortalities worldwide. Despite great efforts to study the cellular and molecular processes underlying fibrosis, there are currently few effective therapies. Dual-stage polymerization reactions an innovative tool recreating heterogeneous increases in extracellular matrix (ECM) modulus, a hallmark fibrotic diseases vivo. Here, we present clickable decellularized ECM (dECM) crosslinker incorporated into dynamically responsive poly(ethylene...
Women with pulmonary arterial hypertension (PAH) exhibit better right ventricular (RV) function and survival than men; however, the underlying mechanisms are unknown. We hypothesized that 17β-estradiol (E2), through estrogen receptor α (ER-α), attenuates PAH-induced RV failure (RVF) by upregulating procontractile prosurvival peptide apelin via a BMPR2-dependent mechanism. found ER-α expression were decreased in homogenates from patients RVF rats maladaptive (but not adaptive) remodeling....
There are no previous reports of the incidence rate intracranial saccular aneurysms in a defined population.Medical records all residents Olmsted County, MN, with possible aneurysm (IA) were reviewed. Incidence rates and prevalence symptomatic asymptomatic IAs, aneurysmal hemorrhage (ICH), frequency IA detection based on size site determined.A total 348 IAs detected among 270 persons during 31-year period from 1965 to 1995, including 188 patients at presentation (166 ICH). The age-...
In 14 anesthetized mongrel dogs, we studied the factors that influenced aortic systolic pressure (PaO) and peak flow (Qao) during positive-pressure inflations at three respiratory rates: 8, 14, 24 breaths/min. At all rates, pulmonary arterial fell by 15% of preinspiratory value end inhalation. Qao also reaching a nadir close to exhalation (EE). less (7% base line) fast rate than medium slow rates (15% line). Pao rose more early part inflation (5 +/- 0.9 Torr) (3 0.7 Torr); then near EE (-5.6...
Abstract High-altitude pulmonary hypertension (HAPH) has heritable features and is a major cause of death in cattle the Rocky Mountains, USA. Although multiple genes are likely involved genesis HAPH, to date no gene variant been identified. Using whole-exome sequencing, we report high association an EPAS1 (HIF2α) double oxygen degradation domain Angus with mean artery pressure >50 mm Hg two independent herds. Expression analysis shows upregulation 26 27 HIF2α target carriers HAPH. Of...
Background and Purpose —There is scant information available on the incidence of transient ischemic attack (TIA) in a defined population. This study defines rates first TIA subtypes during 1985–1989 compares to that obtained from 1960–1972 cohort study. Methods —Medical records all residents Rochester with potential diagnosis were screened determine whether case met criteria for TIA. All data used vascular distribution Average annual age- sex-adjusted calculated 1985–1989, results compared...
We have monitored agonist-induced alpha 1B-adrenergic receptor (alpha 1BAR) redistribution by immunocytochemical procedures in concert with functional measurements of agonist-elicited [3H]inositol phosphate (InsP) production human embryonal kidney 293 cells stably expressing 1BAR cDNA (HEK293/alpha 1B). Anti-peptide antibodies directed against the carboxyl-terminal decapeptide were prepared and shown to react specifically on immunoblots situ HEK293/alpha 1B transfectants. Treatment...
With the
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in (NCT04381936, ISRCTN50189673). In this assessment DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard care alone or plus DMF. The primary outcome was clinical...
<b><i>Objective:</i></b> To determine whether the time of onset subarachnoid hemorrhage (SAH) or intracerebral (ICH) is associated with a day season year. <b><i>Background:</i></b> Prior studies have suggested that there may be circadian and seasonal pattern ischemic stroke occurrence, but this less certain for hemorrhagic stroke. Population-based data been unavailable. <b><i>Methods:</i></b> All incident ICH SAH among residents Rochester, MN, were ascertained. The medical records patients...
The contribution of the alpha-1B adrenergic receptor (AR) to vascular smooth muscle contraction has been assessed using a combination immunological, molecular biological and pharmacological approaches. A subtype-selective antibody detected immunoreactivity in medial layer aorta, caudal, femoral, iliac, mesenteric resistance, renal superior arteries. Receptor protection assays antisense oligonucleotides were used assess AR contraction. was implicated mediating phenylephrine-induced resistance...
Pulmonary hypertension (PH) is a severe cardiopulmonary disease characterized by complement-dependent, fibroblast-induced perivascular accumulation and proinflammatory activation of macrophages. We hypothesized that, in PH, nanoscale-sized small extracellular vesicles (sEVs), released perivascular/adventitial fibroblasts, are critical mediators complement-dependent adventitial fibroblasts were isolated from calves with PH (PH-Fibs) age-matched controls (CO-Fibs). PH-Fibs exhibited increased...
Background and purpose The full spectrum of causes convexal subarachnoid hemorrhage ( cSAH ) requires further investigation. Therefore, our objective was to describe the clinical imaging features patients with non‐traumatic . Methods A retrospective observational study consecutive performed at a tertiary referral center. underlying cause characterized that predict specific etiology were identified. frequency future or intracerebral ICH determined. Results In all, 88 [median age 64 years...