A5075478892- Effects of Radiation Exposure
- Radiation Therapy and Dosimetry
- Spaceflight effects on biology
- Carcinogens and Genotoxicity Assessment
- Oral Health Pathology and Treatment
- Phytase and its Applications
- Insect Resistance and Genetics
- Protein Hydrolysis and Bioactive Peptides
- Protease and Inhibitor Mechanisms
- Oral and gingival health research
- Animal Genetics and Reproduction
- Retinoids in leukemia and cellular processes
- Plant tissue culture and regeneration
- Radiation Effects and Dosimetry
- DNA Repair Mechanisms
- Enzyme Production and Characterization
- Selenium in Biological Systems
- Radiation Dose and Imaging
- Medical Imaging and Pathology Studies
- Glutathione Transferases and Polymorphisms
- COVID-19 Clinical Research Studies
- Cancer Treatment and Pharmacology
- Cancer-related Molecular Pathways
- Phytochemical compounds biological activities
- Medical and Biological Ozone Research
Beaumont Hospital, Royal Oak
2025
University of Oxford
2024
Boston College
2024
Northwestern University
2023
Research Network (United States)
2023
University of Pennsylvania
2011-2021
Nepal Health Research Council
2021
NIHR Clinical Research Network
2021
National Institute for Health Research
2021
National Records of Scotland
2021
PurposeRecent studies suggest that ultrahigh-dose-rate, "FLASH," electron radiation therapy (RT) decreases normal tissue damage while maintaining tumor response compared with conventional dose rate RT. Here, we describe a novel RT apparatus delivers FLASH proton (PRT) using double scattered protons computed tomography guidance and provide the first report of RT-mediated radioprotection.Methods MaterialsAbsolute was measured at multiple depths in solid water validated against an absolute...
The appearance of transformed foci after x-irradiation the C3H 10T1/2 line murine cells requires extensive proliferation followed by prolonged incubation under conditions confluence. When progeny irradiated are resuspended and plated to determine number potential foci, absolute yield is constant over a wide range dilutions similar that observed in cultures have not been resuspended. In addition, for exposed given x-ray dose, per dish independent cells. These observations suggest few, if any,...
Experiments reported here indicate a crude soybean extract, if defatted with acetone, effectively blocks cell transformation in vitro. An active component of this extract is the Bowman-Birk trypsin and chymotrypsin inhibitor. The chymotrypsin-inhibitory region inhibitor responsible for suppressing vitro transformation. Another low molecular weight does not significantly suppress (i) has an irreversible effect on process, (ii) can radiation-induced even when added to cultures many days after...
Dimethylhydrazine (DMH) induces adenocarcinomas of the colon and rectum in rodents; this animal cancer model system is thought to closely resemble human colorectal cancer. An extract soybeans containing Bowman-Birk protease inhibitor added diet DMH-treated mice resulted a significant suppression adenomatous tumors colonic mucosa. Non-treated maintained on same for most their natural life-span (1.5 years) showed no observable health problems.
Abstract The developmental processes of the oligodendrocyte progenitor cell (OPC) lineage that are targeted by interferon‐γ (IFN‐γ) were studied in primary rat OPC cultures. Under conditions thyroid hormone‐mediated differentiation, IFN‐γ produced a dose‐dependent apoptotic response OPCs. lowest dose tested (15 ng/ml or 75 U/ml) was nonapoptotic, but activated detectable STAT1 DNA‐binding. At this dose, reduced percentage mature O1 + cells and increased immature A2B5 This observed without...
Protease inhibitors (PIs), which are widely distributed in plants and animals have a variety of functions, interfere with cancer development number ways, including suppression oxygen radicals, oncogenes, metastases. Epidemiologic evidence supports their prevention major human c
The effect of the Bowman-Birk inhibitor (BBI) and soybean trypsin (SBTI) on experimental 7,12-dimethylbenz[a]anthracene [(DMBA) CAS: 57-97-6]-induced oral carcinogenesis in Syrian male hamsters was examined. All treatments were applied topically both cheek pouches for 20 weeks, animals then sacrificed. Gross microscopic evaluations revealed a statistically significant reduction number invasive carcinomas, total tumors, tumor mass DMBA + BBI treatment group compared to treated with alone,...
It has previously been hypothesized that radiation transformation in vitro is a two-step process; the first step frequent alteration occurring among large fraction of irradiated cells, while second step, malignant transformation, rare event with an approximate frequency 10(-6) progeny cells. Data are reported here on distributions transformed-cell clone sizes cultures reseeded at various times post-treatment. The results suggest occurs randomly during growth C3H 10T1/2 cells to confluence....
The purpose of this study was to determine whether a dietary supplement consisting L-selenomethionine, vitamin C, E succinate, alpha-lipoic acid and N-acetyl cysteine could improve the survival mice after total-body irradiation. Antioxidants significantly increased 30-day exposure potentially lethal dose X rays when given prior or animal Pretreatment animals with antioxidants resulted in higher total white blood cell neutrophil counts peripheral at 4 24 h 1 Gy 8 Gy. were effective preventing...
In the present study, we examined ability of chymostatin, a highly specific inhibitor chymotrypsin, to suppress dimethylhydrazine-induced colon carcinogenesis, and dose-response relationship for an extract soybeans containing Bowman-Birk (BBI) when added diet mice. Our results showed that: (i) diets 0.1% BBI reduced incidence adenocarcinomas ∼50%, but had no effect on squamous cell carcinomas anal gland; (ii) suppressive requires protease activity, as autoclaved BBI, in which all inhibitory...