A5061020099- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Intracerebral and Subarachnoid Hemorrhage Research
- Advanced Neuroimaging Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Venous Thromboembolism Diagnosis and Management
- Genetic Associations and Epidemiology
- Cerebrovascular and genetic disorders
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Peripheral Artery Disease Management
- Dementia and Cognitive Impairment Research
- Neurological Disorders and Treatments
- Neurosurgical Procedures and Complications
- MRI in cancer diagnosis
- Moyamoya disease diagnosis and treatment
- Cardiovascular Health and Disease Prevention
- RNA regulation and disease
- Folate and B Vitamins Research
- Medical Image Segmentation Techniques
- Atrial Fibrillation Management and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Cardiovascular Health and Risk Factors
Harvard University
2016-2025
Massachusetts General Hospital
2016-2025
Montefiore Medical Center
2023
Texas Neurology
2022-2023
Rush University Medical Center
2023
Children's Hospital of Philadelphia
2023
University of Michigan
2023
The University of Texas Southwestern Medical Center
2023
University of Pennsylvania
2023
New York University
2023
The role of C-reactive protein (CRP) as a novel plasma marker atherothrombotic disease is currently under investigation. Previous studies have mostly related CRP to coronary heart disease, were often restricted case-control design, and failed include pertinent risk factors evaluate the joint net effect on outcome. We levels incidence first ischemic stroke or transient attack (TIA) in Framingham Study original cohort.There 591 men 871 women free stroke/TIA during their 1980 1982 clinic...
Intracerebral hemorrhage (ICH) is the most fatal and disabling stroke subtype. Widely used tools for prediction of mortality are fundamentally limited in that they do not account effects withdrawal care designed to predict functional recovery. We developed an acute clinical score likelihood independence.We prospectively characterized 629 consecutive patients with ICH at hospital presentation. Predictors independence (Glasgow Outcome Score > or = 4) 90 days were develop a logistic...
Many clinical trials focus on restricting hematoma expansion following acute intracerebral hemorrhage (ICH), but selecting those patients at highest risk of is challenging.To develop a prediction score for in with primary ICH.Prospective cohort study 2 urban academic medical centers among having ICH available baseline and follow-up computed tomography volumetric analysis (817 the development 195 independent validation cohort).Hematoma was assessed using semiautomated software defined as more...
Abstract Objective Prior studies investigating the association between APOE alleles ε2/ε4 and risk of intracerebral hemorrhage (ICH) have been inconsistent limited to small sample sizes, did not account for confounding by population stratification or determine which genetic model was best applied. Methods We performed a large‐scale study 2189 ICH cases 4041 controls from 7 cohorts, were analyzed using additive models ε2 ε4. Results subsequently meta‐analyzed random effects model. A...
Stroke is among the leading causes of morbidity and mortality worldwide. Without reliable prediction models outcome measurements, comparison care systems impossible. We analyzed prospectively collected data from 4 countries to explore importance stroke severity in prediction.For 2 months, all acute ischemic patients hospitals participating Global Comparators GOAL (Global Outcomes Accelerated Learning) collaboration received a National Institutes Health Scale (NIHSS) score on admission...
Importance It remains unclear why lesions in some locations cause epilepsy while others do not. Identifying the brain regions or networks associated with by mapping these could inform prognosis and guide interventions. Objective To assess whether lesion map to specific networks. Design, Setting, Participants This case-control study used location network identify a discovery data set of patients poststroke control stroke. Patients stroke (n = 76) no 625) were included. Generalizability other...
<b>Background:</b> Leukoaraiosis (LA) is closely associated with aging, a major determinant of clinical outcome after ischemic stroke. In this study we sought to identify whether LA, independent advancing age, affects acute <b>Methods:</b> LA volume was quantified in 240 patients stroke and MRI within 24 hours symptom onset. We explored the relationship between at admission 6 months, as assessed by modified Rankin Scale (mRS). An ordinal logistic regression model developed analyze effect on...
Background and Purpose— Because of a shortage stroke specialists, many outlying or “spoke” hospitals initiate intravenous (IV) thrombolysis using telemedicine telephone consultation before transferring patients to regional center (RSC) hub. We analyzed complications outcomes treated with IV tissue plasminogen activator (tPA) the “drip ship” approach compared those directly at RSC. Methods— A retrospective review our Get With Guidelines Stroke (GWTG-Stroke) database from 01/2003 03/2008...
<h3>Importance</h3> Hematoma volume is the strongest predictor of outcome in intracerebral hemorrhage (ICH). Despite known differences underlying biology between deep and lobar ICHs, limited data are available on location specificity factors reported to affect hematoma volume. <h3>Objective</h3> To evaluate whether determinants ICH differ by topography, we sought estimate location-specific effects for potential predictors this radiological outcome. <h3>Design</h3> Prospective cohort study....
<h3>Objective:</h3> White matter hyperintensity (WMH) may be a marker of an underlying cerebral microangiopathy. Therefore, we hypothesized that WMH would most severe in patients with lacunar stroke and intracerebral hemorrhage (ICH), 2 types which small vessel (SV) changes are pathophysiologically relevant. <h3>Methods:</h3> We determined volume (WMHV) cohorts prospectively ascertained acute ischemic (AIS) (Massachusetts General Hospital [MGH], n = 628, the Ischemic Stroke Genetics Study...
Acute infarct volume, often proposed as a biomarker for evaluating novel interventions acute ischemic stroke, correlates only moderately with traditional clinical end points, such the modified Rankin Scale. We hypothesized that topography of stroke lesions on diffusion-weighted magnetic resonance imaging may provide further information regard to presenting severity and long-term functional outcomes. Data from prospective repository were limited subjects completed within 48 hours last known...