Sherry Chou
A5013124190- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Long-Term Effects of COVID-19
- Intracranial Aneurysms: Treatment and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- COVID-19 Clinical Research Studies
- Neurosurgical Procedures and Complications
- Traumatic Brain Injury Research
- Intensive Care Unit Cognitive Disorders
- Psychosomatic Disorders and Their Treatments
- Cardiac Arrest and Resuscitation
- Cerebrovascular and Carotid Artery Diseases
- Cerebral Venous Sinus Thrombosis
- Epilepsy research and treatment
- COVID-19 and healthcare impacts
- Venous Thromboembolism Diagnosis and Management
- Infectious Encephalopathies and Encephalitis
- COVID-19 and Mental Health
- Neurological and metabolic disorders
- S100 Proteins and Annexins
- Pharmacological Effects and Toxicity Studies
- Cerebrovascular and genetic disorders
- Functional Brain Connectivity Studies
- Cerebrospinal fluid and hydrocephalus
- Neuroinflammation and Neurodegeneration Mechanisms
Northwestern University
2022-2025
NewYork–Presbyterian Hospital
2021-2024
Presbyterian Hospital
2024
New York Hospital Queens
2024
Columbia University
2024
University of Pennsylvania
2021-2024
Harvard University
2005-2023
Massachusetts General Hospital
2006-2023
King's College London
2023
National Taiwan University Hospital
2023
<h3>Importance</h3> The COVID-19 pandemic continues to affect millions of people globally, with increasing reports neurological manifestations but limited data on their incidence and associations outcome. <h3>Objective</h3> To determine the phenotypes, incidence, outcomes among adults hospitalized COVID-19. <h3>Design, Setting, Participants</h3> This cohort study included patients clinically diagnosed or laboratory-confirmed at 28 centers, representing 13 countries 4 continents. was...
Many clinical trials focus on restricting hematoma expansion following acute intracerebral hemorrhage (ICH), but selecting those patients at highest risk of is challenging.To develop a prediction score for in with primary ICH.Prospective cohort study 2 urban academic medical centers among having ICH available baseline and follow-up computed tomography volumetric analysis (817 the development 195 independent validation cohort).Hematoma was assessed using semiautomated software defined as more...
To determine the prevalence and associated mortality of well-defined neurologic diagnoses among patients with coronavirus disease 2019 (COVID-19), we prospectively followed hospitalized severe acute respiratory syndrome 2 (SARS-CoV-2)-positive recorded new disorders hospital outcomes.
Intracerebral hemorrhage (ICH) is a devastating form of stroke affecting millions people worldwide. Parenchymal hematoma triggers series reactions leading to primary and secondary brain injuries permanent neurological deficits. Microglia macrophages carry out clearance, thereby facilitating functional recovery after ICH. Here, we elucidate pivotal role for the interleukin (IL)-4)/signal transducer activator transcription 6 (STAT6) axis in promoting long-term both blood- collagenase-injection...
Cerebral autoregulation may be impaired in the early days after subarachnoid hemorrhage (SAH). The purpose of this study was to examine relationship between cerebral and angiographic vasospasm (aVSP) radiographic delayed ischemia (DCI) patients with SAH.Sixty-eight (54±13 years) a diagnosis nontraumatic SAH were studied. Dynamic assessed using transfer function analysis (phase gain) spontaneous blood pressure flow velocity oscillations on 2 4 post-SAH. aVSP diagnosed 4-vessel conventional...
an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) international outbreak.The World Health Organization designated this as a global pandemic on March 11, 2020, with over 200 countries affected worldwide.As of April 24, there were 790 986 patients confirmed COVID-19 and 195 775 deaths worldwide, the United States, Spain, Italy, France, Germany, Kingdom, Turkey, Iran surpassing China in number cases. 1 In consecutive series 221 admitted to hospital...
Background and Purpose— Recent studies suggest that extracellular mitochondria may be involved in the pathophysiology of stroke. In this study, we assessed functional relevance endogenous cerebrospinal fluid (CSF) rats humans after subarachnoid hemorrhage (SAH). Methods— A standard rat model SAH was used, where an intraluminal suture used to perforate a cerebral artery, thus leading blood extravasation into space. At 24 72 hours SAH, neurological outcomes were measured, JC1...
As the COVID-19 pandemic developed, reports of neurological dysfunctions spanning central and peripheral nervous systems have emerged. The spectrum acute may implicate direct viral invasion, para-infectious complications, manifestations systemic diseases, or co-incident dysfunction in context high SARS-CoV-2 prevalence. A rapid pragmatic approach to understanding prevalence, phenotypes, pathophysiology prognostic implications syndromes is urgently needed. Global Consortium Study Neurological...
Background and Purpose— EG-1962 is a sustained release formulation of nimodipine administered via external ventricular drain in patients with aneurysmal subarachnoid hemorrhage. A randomized, open-label, phase 1/2a, dose-escalation study provided impetus for this to evaluate efficacy safety single intraventricular 600 mg dose hemorrhage, compared standard care oral nimodipine. Methods— Subjects were World Federation Neurological Surgeons grades 2–4, modified Fisher 2–4 had an inserted as...
Abstract Coma and disorders of consciousness (DoC) are highly prevalent constitute a burden for patients, families, society worldwide. As part the Curing Campaign, Neurocritical Care Society partnered with National Institutes Health to organize symposium bringing together experts from all over world develop research targets DoC. The conference was structured along six domains: (1) defining endotype/phenotypes, (2) biomarkers, (3) proof-of-concept clinical trials, (4) neuroprognostication,...
Hyperglycemia strongly predicts poor outcome in patients with aneurysmal subarachnoid hemorrhage, but the effect of hyperglycemia management on is unclear. We studied impact glycemic control hemorrhage.A prospective intensive care unit database was used to identify 332 hyperglycemic hemorrhage admitted between January 2000 and December 2006. Patients treated an aggressive (AHM) protocol after 2003 (N=166) were compared 166 using a standard before 2003. Within AHM group, who achieved good...
Cerebral edema is a key poor prognosticator in traumatic brain injury. There are no biomarkers identifying patients at-risk, or guiding mechanistically-precise therapies. Sulfonylurea receptor-1-transient receptor potential cation channel M4 upregulated only after injury, causing animal studies. We hypothesized that sulfonylurea receptor-1 measurable human cerebrospinal fluid severe injury and an informative biomarker of outcome.A total 119 samples were collected from 28 patients. Samples...
The COVID-19 pandemic is a global public health issue. Neurological complications have been reported in up to one-third of affected cases, but their distribution varies significantly terms prevalence, incidence and phenotypical characteristics. Variability can be mostly explained by the differing sources cases (hospital vs. community-based), accuracy diagnostic approach interpretation patients' complaints. Moreover, after recovering, patients still experience neurological symptoms. To obtain...
Abstract Oral nimodipine is the only drug approved in North America for patients with aneurysmal subarachnoid hemorrhage (aSAH). However, bioavailability variable and frequently poor, leading to fluctuations peak plasma concentrations that cause dose-limiting hypotension. Furthermore, administration problematic who cannot swallow. An oral liquid formulation exists but causes diarrhea. intravenous (GTX-104) has been developed approaching 100% not affected by feeding or gastrointestinal...