A5090506665- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and Carotid Artery Diseases
- Neurosurgical Procedures and Complications
- Vascular Malformations Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Moyamoya disease diagnosis and treatment
- Cerebrospinal fluid and hydrocephalus
- Meningioma and schwannoma management
- Brain Metastases and Treatment
- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Aortic aneurysm repair treatments
- Cancer Cells and Metastasis
- Intensive Care Unit Cognitive Disorders
- Single-cell and spatial transcriptomics
- Cancer, Hypoxia, and Metabolism
- Immunotherapy and Immune Responses
- Cerebral Venous Sinus Thrombosis
- Head and Neck Surgical Oncology
- Cell Image Analysis Techniques
- Trauma and Emergency Care Studies
- Vitamin D Research Studies
University Medical Centre Mannheim
2016-2025
Heidelberg University
2016-2025
University Hospital Heidelberg
2016-2025
University of Mannheim
2021-2024
Erasmus MC
2022
University Health Network
2022
University Medical Center Utrecht
2022
Utrecht University
2022
Radboud University Nijmegen
2022
Radboud University Medical Center
2022
We endeavored to develop an unruptured intracranial aneurysm (UIA) treatment score (UIATS) model that includes and quantifies key factors involved in clinical decision-making the management of UIAs assess agreement for this among specialists UIA research.
To develop and validate a set of practical prediction tools that reliably estimate the outcome subarachnoid haemorrhage from ruptured intracranial aneurysms (SAH).Cohort study with logistic regression analysis to combine predictors treatment modality.Subarachnoid Haemorrhage International Trialists' (SAHIT) data repository, including randomised clinical trials, prospective observational studies, hospital registries.Researchers collaborated pool datasets registries, trials SAH multiple...
Meningiomas are the most frequent primary intracranial tumors. Patient outcome varies widely from benign to highly aggressive, ultimately fatal courses. Reliable identification of risk progression for individual patients is pivotal importance. However, only biomarkers aggressive tumors established (CDKN2A/B and TERT), whereas no molecularly based stratification exists broad spectrum with low- intermediate-risk meningioma.DNA methylation data copy-number information were generated 3,031...
Unruptured intracranial aneurysms (UIA) occur in around 3% of the population. Important management questions concern if and how to perform preventive UIA occlusion; if, when follow up imaging non-interventional means reduce risk rupture. Using Standard Operational Procedure ESO we prepared guidelines according GRADE methodology. Since no completed randomised trials exist, used interim analyses trials, meta-analyses observational case-control studies provide recommendations guide management....
Background and Purpose— Patients are classically at risk of delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage. We validated a grading scale—the VASOGRADE—for prediction DCI. Methods— used data 3 phase II randomized clinical trials single hospital series to assess the relationship between VASOGRADE The derived from previously published charts consists categories: VASOGRADE-Green (modified Fisher scale 1 or 2 World Federation Neurosurgical Societies [WFNS] 2);...
Unruptured intracranial aneurysms not undergoing preventive endovascular or neurosurgical treatment are often monitored radiologically to detect aneurysm growth, which is associated with an increase in risk of rupture. However, the absolute rupture after detection growth remains unclear. To determine during follow-up and develop a prediction model for Individual patient data were obtained from 15 international cohorts. Patients 18 years older who had imaging at least 1 untreated unruptured...
Abstract Background Glioblastomas are characterized by aggressive and infiltrative growth, striking heterogeneity. The aim of this study was to investigate whether tumor cell proliferation invasion interrelated, or rather distinct features different populations. Methods Tumor were longitudinally determined in real-time using 3D vivo 2-photon laser scanning microscopy over weeks. Glioblastoma cells expressed fluorescent markers that permitted the identification their mitotic history cycling...
BACKGROUND: Microscope-based intraoperative near-infrared indocyanine green (ICG) videoangiography is useful as an adjunct to intra- or postoperative digital subtraction angiography (DSA) in aneurysm surgery. OBJECTIVE: To evaluate ICG for surgery of arteriovenous malformations (AVMs) and dural fistulas (dAVFs). METHODS: Seventeen patients undergoing surgical resection intracranial AVM AVF were enrolled into this prospective evaluation. sequences analyzed with regard transit times...
Background and Purpose— To address the increasing need to counsel patients about treatment indications for unruptured intracranial aneurysms (UIA), we endeavored develop a consensus on assessment of UIAs among group specialists from diverse fields involved in research UIAs. Methods— After composition group, Delphi was initiated identify rate all features, which may be relevant assess their by using ranking scales analysis inter-rater agreement (IRA) each factor. IRA categorized as very high,...
Intraoperative measurements of cerebral blood flow are interest during vascular neurosurgery. Near-infrared indocyanine green (ICG) fluorescence angiography was introduced for visualizing vessel patency intraoperatively. However, quantitative information has not been available.To report our experience with a microscope an integrated dynamic ICG analysis system supplying semiquantitative on flow.We recorded curves cortex and vessels using software into the surgical (Flow 800 software; Zeiss...
To date, there is no immediate radiographic surrogate to quantify primary cerebral injury identify patients at risk for delayed ischemia and poor clinical outcome after aneurysmal subarachnoid hemorrhage. Therefore, we investigated the relation of early perfusion-computerized tomography clot volume with radiological events in hemorrhage.Data from 2 cohorts (51 main, 28 control cohort) hemorrhage, receiving computerized scanning <12 hours ictus, were included. A group model functional was...
We conducted a randomized, open-label, phase 1/2a, dose-escalation study of intraventricular sustained-release nimodipine (EG-1962) to determine safety, tolerability, pharmacokinetics, and clinical effects in aneurysmal subarachnoid hemorrhage. Subjects with hemorrhage repaired by clipping or coiling were randomized EG-1962 enteral nimodipine. World Federation Neurological Surgeons grade 2 4 had an external ventricular drain. Cohorts 12 subjects received 100 1200 mg (9 per cohort) (3...
Diffuse IDH-mutant astrocytic tumors are rarely diagnosed in the cerebellum or brainstem. In this multi-institutional study, we characterized a series of primary infratentorial with respect to clinical and molecular parameters. We report that about 80% IDH mutations these non-IDH1-R132H variants which rare supratentorial astrocytomas. Most frequently, IDH1-R132C/G IDH2-R172S/G were present. Moreover, frequencies ATRX-loss MGMT promoter methylation, typically associated tumors, significantly...