Sepideh Amin‐Hanjani
A5070619742- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Vascular Malformations Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Moyamoya disease diagnosis and treatment
- Neurosurgical Procedures and Complications
- Meningioma and schwannoma management
- Cerebral Venous Sinus Thrombosis
- Spinal Fractures and Fixation Techniques
- Advanced MRI Techniques and Applications
- Cerebrospinal fluid and hydrocephalus
- Cardiovascular Health and Disease Prevention
- Neurological Complications and Syndromes
- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Head and Neck Surgical Oncology
- Peripheral Artery Disease Management
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Vascular Anomalies and Treatments
- Glioma Diagnosis and Treatment
- Spinal Dysraphism and Malformations
- Spine and Intervertebral Disc Pathology
University of Illinois Chicago
2016-2025
University School
2022-2025
Case Western Reserve University
2022-2025
University Hospitals of Cleveland
2023-2025
University of Illinois Urbana-Champaign
2014-2024
Illinois College
2011-2024
Neurological Surgery
2009-2024
University of Miami
2023
Lahey Hospital and Medical Center
2009-2022
Lahey Medical Center
2022
The aim of this updated statement is to provide comprehensive and evidence-based recommendations for management patients with unruptured intracranial aneurysms.Writing group members used systematic literature reviews from January 1977 up June 2014. They also reviewed contemporary published guidelines, personal files, expert opinion summarize existing evidence, indicate gaps in current knowledge, when appropriate, formulated using standard American Heart Association criteria. guideline...
The comparative effectiveness of performing instrumented (rigid pedicle screws affixed to titanium alloy rods) lumbar spinal fusion in addition decompressive laminectomy patients with symptomatic grade I degenerative spondylolisthesis stenosis is unknown.In this randomized, controlled trial, we assigned patients, 50 80 years age, who had stable (degree spondylolisthesis, 3 14 mm) and undergo either alone (decompression-alone group) or posterolateral (fusion group). primary outcome measure...
Atypical meningioma (AM) patients often undergo gross total resection (GTR) at the time of presentation, but subsequent prognosis and optimal management remain unclear. We sought to define long-term recurrence rate AMs after GTR, along with factors predicting recurrence, including postoperative radiation.We performed a retrospective review 108 GTR our institution from 1993 2004. Recurrence risk were analyzed using multivariate Cox regression.There 600 patient-years imaging follow-up on 48...
We endeavored to develop an unruptured intracranial aneurysm (UIA) treatment score (UIATS) model that includes and quantifies key factors involved in clinical decision-making the management of UIAs assess agreement for this among specialists UIA research.
Importance Prior trials of extracranial-intracranial (EC-IC) bypass surgery showed no benefit for stroke prevention in patients with atherosclerotic occlusion the internal carotid artery (ICA) or middle cerebral (MCA), but there have been subsequent improvements surgical techniques and patient selection. Objective To evaluate EC-IC symptomatic ICA MCA, using refined operator Design, Setting, Participants This was a randomized, open-label, outcome assessor–blinded trial conducted at 13...
Previous randomized clinical trials did not demonstrate the superiority of endovascular stenting over aggressive medical management for patients with symptomatic intracranial atherosclerotic stenosis (sICAS). However, balloon angioplasty has been investigated in a trial.
Intracranial atherosclerotic disease and resultant intracranial stenosis is a global leading cause of stroke, poses an ongoing treatment challenge. Among patients with stenosis, those hemodynamic compromise are at high risk for recurrent stroke despite medical therapy factor modification. Revascularization the hypoperfused territory most plausible strategy these high-risk patients, yet surgical endovascular therapies have not shown to be sufficiently safe effective in randomized controlled...
Background and Purpose —The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) lower serum cholesterol decrease the incidence of stroke cardiovascular disease. There is growing evidence that statins exert some their beneficial effects independent lowering. Indeed, we have previously demonstrated chronic simvastatin administration upregulates endothelial nitric oxide synthase (eNOS), resulting in more functional protein, augmentation cerebral blood flow,...
Caspase-11, a member of the murine caspase family, has been shown to be an upstream activator caspase-1 in regulating cytokine maturation. We demonstrate here that addition its defect maturation, caspase-11–deficient mice have reduced number apoptotic cells and caspase-3 activation after middle cerebral artery occlusion (MCAO), mouse model stroke. Recombinant procaspase-11 can autoprocess itself vitro. Purified active recombinant caspase-11 cleaves activates procaspase-3 very efficiently....
Cerebral blood flow is regulated by endothelium-derived nitric oxide (NO), and endothelial NO synthase–deficient (eNOS-deficient; eNOS–/–) mice develop larger cerebral infarctions following middle artery (MCA) occlusion. We report that disruption of Rho-mediated actin cytoskeleton leads to the upregulation eNOS expression reduces severity ischemia MCA Mice treated with Rho inhibitor Clostridium botulinum C3 transferase (10 μg/d) or disrupter cytochalasin D (1 mg/kg) showed a two- fourfold...
Mitochondria and cytochrome c release play a role in the death of neurons glia after cerebral ischemia. In present study, we investigated whether BID, proapoptotic promoter caspase 8 substrate, was expressed brain, activated an ischemic insult vivo vitro , contributed to cell death. We detected BID cytosol mouse brain primary cultured demonstrated, by using recombinant 8, that neuronal also is substrate. After 2 h oxygen/glucose deprivation, cleavage concurrent with activation but before 3...
Hemorrhages from cerebral cavernous malformations (CMs) sometimes seem to occur in closely spaced "clusters" interspersed with long hemorrhage-free intervals. Clustering of hemorrhages could affect retrospective assessments radiosurgery efficacy prevention CM rehemorrhage. However, this empirical observation had not been tested quantitatively. To test whether tend cluster, we reviewed pretreatment rebleeding rates after a first symptomatic hemorrhage patients who later underwent surgery or...
Object. There is considerable debate among spine surgeons regarding whether fusion should be used to augment decompressive surgery in patients with symptomatic lumbar spinal stenosis involving Grade I degenerative spondylolisthesis. The authors prospectively evaluated the outcomes of treated between 2000 and 2002 at two institutions determine improves functional outcome 1 year after surgery. Methods. Patients ranged age from 50 81 years. They presented (3- 14-mm) spondylolisthesis without...
<b>BACKGROUND AND PURPOSE:</b> We sought to derive regional cerebral blood flow using vessel flows from quantitative MR angiography (qMRA). <b>MATERIALS METHODS:</b> Flow rates in the 15 major arteries were measured on retrospectively gated fast 2D phase-contrast obtained 83 healthy adult volunteers (age range, 24–74 years; mean, 42 years). The arterial network of brain was partitioned into 12 different regions, which calculated arteries. <b>RESULTS:</b> mean and regions calculated. total...
Atherosclerotic vertebrobasilar (VB) occlusive disease is a significant etiology of posterior circulation stroke, with regional hypoperfusion as an important potential contributor to stroke risk.To test the hypothesis that, among patients symptomatic VB stenosis or occlusion, those distal blood flow compromise measured by large-vessel quantitative magnetic resonance angiography (QMRA) are at higher risk subsequent stroke.A prospective, blinded, longitudinal cohort study was conducted 5...
Abstract BACKGROUND Minimally invasive surgery procedures, including stereotactic catheter aspiration and clearance of intracerebral hemorrhage (ICH) with recombinant tissue plasminogen activator hold a promise to improve outcome supratentorial brain hemorrhage, morbid disabling type stroke. A recently completed Phase III randomized trial showed improved mortality but was neutral on the primary (modified Rankin scale score 0 3 at 1 yr). OBJECTIVE To assess surgical performance its impact...