A5091449910- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Stroke Rehabilitation and Recovery
- Neurological Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological Disorders and Treatments
- Advanced Neuroimaging Techniques and Applications
- Dementia and Cognitive Impairment Research
- Intracranial Aneurysms: Treatment and Complications
- Cardiac Ischemia and Reperfusion
- Cerebral Venous Sinus Thrombosis
- Alzheimer's disease research and treatments
- Transcranial Magnetic Stimulation Studies
- Anesthesia and Neurotoxicity Research
- Cerebrovascular and genetic disorders
- Advanced MRI Techniques and Applications
- COVID-19 and healthcare impacts
- Gaze Tracking and Assistive Technology
- Cardiovascular Health and Disease Prevention
- Atrial Fibrillation Management and Outcomes
- Moyamoya disease diagnosis and treatment
- Lipoproteins and Cardiovascular Health
Capital Medical University
2016-2025
Xuan Wu Hospital of the Capital Medical University
2010-2024
Chinese Institute for Brain Research
2015-2024
Clinical Trial Investigators
2024
Harvard University
2022
Twin Cities Orthopedics
2022
University of Minnesota
2022
University of New Mexico
2022
Beth Israel Deaconess Medical Center
2017-2022
Institute of Genetics and Developmental Biology
2022
The effects and risks of endovascular thrombectomy 6 to 24 hours after stroke onset due basilar-artery occlusion have not been extensively studied.
The Chinese population has been aging rapidly and the country's economy experienced exponential growth during past three decades. goal of this study was to estimate changes in prevalence dementia, Alzheimer's disease (AD), vascular dementia (VaD) among elderly individuals analyze differences between urban rural areas.For years 2008 2009, we performed a population-based cross-sectional survey with multistage cluster sampling design. Residents aged 65 older were drawn from 30 (n = 6096) 45...
Prior randomized trials have generally shown harm or no benefit of stenting added to medical therapy for patients with symptomatic severe intracranial atherosclerotic stenosis, but it remains uncertain as whether refined patient selection and more experienced surgeons might result in improved outcomes.To compare plus vs alone stenosis.Multicenter, open-label, randomized, outcome assessor-blinded trial conducted at 8 centers China. A total 380 transient ischemic attack nondisabling,...
Importance Prior trials of extracranial-intracranial (EC-IC) bypass surgery showed no benefit for stroke prevention in patients with atherosclerotic occlusion the internal carotid artery (ICA) or middle cerebral (MCA), but there have been subsequent improvements surgical techniques and patient selection. Objective To evaluate EC-IC symptomatic ICA MCA, using refined operator Design, Setting, Participants This was a randomized, open-label, outcome assessor–blinded trial conducted at 13...
Evidence supports using antiplatelet therapy in patients with acute ischemic stroke. However, neurological deterioration remains common under the currently recommended regimen, leading to poor clinical outcomes.
Epidemiologic studies on mild cognitive impairment (MCI) are limited in China.Using a multistage cluster sampling design, total of 10,276 community residents (6096 urban, 4180 rural) aged 65 years or older were evaluated and diagnosed with normal cognition, MCI, dementia. MCI was further categorized by imaging into caused prodromal Alzheimer's disease (MCI-A), resulting from cerebrovascular (MCI-CVD), vascular risk factors (MCI-VRF), other diseases (MCI-O).The prevalences overall MCI-A,...
Background and Purpose— Chinese patients largely experience acute ischemic stroke (AIS) because of large artery atherosclerosis rather than cardioembolism, whether tirofiban is safe effective in these treated with endovascular thrombectomy (ET) unknown. This study evaluated the safety efficacy AIS ET. Methods— observational based on a single-center prospective registry study. Patients undergoing ET second-generation stent retrievers from January 2013 to February 2017 were alone or plus low...
Abstract Introduction Vascular cognitive impairment without dementia is very common among the aged and tends to progress dementia, but there have been no proper large‐scale intervention trials dedicated it. caused by subcortical ischemic small vessel disease (hereinafter, dementia) represents a relatively homogeneous process suitable target for therapeutic investigating dementia. Preclinical showed that dl‐3‐n‐butylphthalide (NBP) effective of vascular origin. Methods In this randomized,...
We aimed to evaluate the efficacy of remote ischemic conditioning (RIC) in patients with cerebral small-vessel disease.Thirty disease-related mild cognitive impairment were enrolled this prospective, randomized controlled study for 1 year. Besides routine medical treatment, participants into experimental group (n=14) undergoing 5 cycles consisting ischemia followed by reperfusion minutes on both upper limbs twice daily year or control (n=16) who treated sham ischemia-reperfusion cycles. The...
Abstract Treatment of depression with antidepressants is partly effective. Transcranial alternating current stimulation can provide a non-pharmacological alternative for adult patients major depressive disorder. However, no study has used the to treat first-episode and drug-naïve We randomized, double-blind, sham-controlled design examine clinical efficacy safety in treating Chinese Han population. From 4 June 2018 30 December 2019, 100 were recruited randomly assigned receive 20 daily...
Rationale There are no randomized trials examining the best treatment for acute basilar artery occlusion in 6–24-hour time window. Aims To assess safety and efficacy of thrombectomy stroke due to patients within 6–24 h from symptom onset or last seen well. Sample size For an estimated difference 20% proportions primary outcome between two groups, 318 will be included 5% significance 90% power with a planned interim analysis after two-thirds sample (212 patients) have achieved 90 days...
Post-stroke cognitive impairment (PSCI) is a common sequela after stroke. China has large population of stroke survivors, but large-scale survey on the incidence and risk factors for PSCI not been undertaken. We aimed to calculate vascular symptoms among first-ever survivors in through multicenter cross-sectional study.From May 1, 2019 November 30, 2019, patients with clinical diagnosis ischemic were recruited from 563 hospitalized-based center networks 30 provinces China. Cognitive was...
Importance Preclinical and clinical studies have suggested the neuroprotective effect of Panax notoginseng saponins (Xuesaitong soft capsules). However, robust evidence in patients with ischemic stroke is lacking. Objective To assess efficacy safety Xuesaitong capsules stroke. Design, Setting, Participants This multicenter, double-blind, placebo-controlled randomized trial was conducted at 67 tertiary health centers China from July 1, 2018, to June 30, 2020. Included were aged 18 75 years a...
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) heterozygous HTRA1 mutation-related cerebral small vessel disease (CSVD) are the two types of hereditary CSVD. Blood-brain barrier (BBB) failure has been hypothesized in pathophysiology However, it is unclear whether there BBB damage CSVD, especially In this study, a case-control design was used groups including CADASIL (n = 24), CSVD 9) healthy controls 24). All participants underwent...
We aim to clarify the mechanisms of acupuncture in treating mild cognitive impairment (MCI) and Alzheimer disease (AD) by using functional magnetic resonance imaging (fMRI). Thirty-six right-handed subjects (8 MCI patients, 14 AD healthy elders) participated this study. Clinical neuropsychological examinations were performed on all subjects. MRI data acquisition was a SIEMENS verio 3-Tesla scanner. The fMRI study used single block experimental design. first acquired baseline resting state...
Acupuncture has been used in the therapy of Alzheimer disease (AD); however, its neural mechanisms are still unclear. The aim this study is to examine effect acupuncture on functional connectivity AD by using resting-state magnetic resonance imaging (rs-fMRI). Twenty-eight subjects (14 and 14 normal controls) participated study. rs-fMRI data were acquired before after stimulation at acupoints Tai chong (Liv3) Hegu (LI4). During baseline resting state, amplitude low-frequency fluctuations...
The baseline and longitudinal changes of the posterior cingulate cortex (PCC) connectivity were assessed in order to clarify neural mechanism mild cognitive impairment (MCI). Twenty-eight right-handed subjects (14 MCI patients 14 healthy elders) participated this study. Clinical neuropsychological examinations performed on all subjects. PCC functional was studied by examining correlation between low frequency fMRI signal fluctuations those other brain regions. Additionally, we traced...
Background and Purpose— The aim of the present study was to investigate atherosclerotic plaque characteristics in patients with artery-to-artery (A-to-A) embolic infarction by whole-brain high-resolution magnetic resonance imaging. Methods— Seventy-four (mean age, 54.7±12.1 years; 59 men) recent stroke territory middle cerebral artery because intracranial disease were prospectively enrolled. Whole-brain imaging performed all both precontrast postcontrast administration using a 3-dimensional...
Background Intracranial atherosclerotic disease tends to affect multiple arterial segments. Using whole‐brain vessel wall imaging, we sought study the differences in plaque features among various types of plaques patients with a recent unilateral anterior circulation ischemic stroke. Methods and Results Sixty‐one stroke were referred undergo imaging (before after contrast) within 1 month symptom onset for intracranial evaluations. Each was classified as culprit, probably or nonculprit...
Alzheimer's disease (AD) is the most common cause of dementia. Previous studies have found disrupted resting state functional connectivities (rsFCs) in various brain networks AD patients. However, few focused on rsFCs cerebellum and its sub-regions In this study, we collected resting-state magnetic resonance imaging (rs-fMRI) data including 32 patients 38 healthy controls (HCs). We selected two cognitive-related subregions as seed region mapped whole-brain for each subregion. identified...
Background and purpose Idiopathic intracranial hypertension ( IIH ) is characterized by abnormally elevated pressure ICP without identifiable etiology. Recently, however, a subset of patients with presumed have been found isolated internal jugular vein IJV stenosis in the absence abnormalities. Methods Fifteen consecutive were screened from 46 suspected as finally confirmed stenosis. The stenotic was corrected stenting when trans‐stenotic mean gradient (∆ MPG equal to or higher than 5.44 cmH...
Recent studies have demonstrated the close relationship between regional cerebral blood flow (rCBF) and resting state functional connectivity changes in normal healthy people. However, little is known about different parameters of most vulnerable regions Alzheimer's disease (AD). In this study, we collected resting-state perfusion magnetic resonance imaging (fMRI) data including 40 AD patients 30 controls. By using voxel wise arterial spin labeling (ASL) perfusion, firstly identified several...
The novel coronavirus disease 2019 (COVID-19) pandemic is still spreading across the world. Although has an all-round impact on medical work, degree of its endovascular thrombectomy (EVT) for patients with acute ischemic stroke (AIS) unclear.We continuously included AIS large artery occlusion who underwent EVT in a comprehensive center before and during Wuhan shutdown. protected code (PCS) screening treating was established pandemic. efficacy safety outcomes including rate successful...