A5088127595- Acute Myeloid Leukemia Research
- CRISPR and Genetic Engineering
- Chronic Myeloid Leukemia Treatments
- Pluripotent Stem Cells Research
- Hematopoietic Stem Cell Transplantation
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Insect Resistance and Genetics
- Immune Cell Function and Interaction
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- CAR-T cell therapy research
- RNA modifications and cancer
- Virus-based gene therapy research
- Protein Degradation and Inhibitors
- Viral Infectious Diseases and Gene Expression in Insects
- Acute Ischemic Stroke Management
- T-cell and B-cell Immunology
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Multiple Myeloma Research and Treatments
- Mesenchymal stem cell research
- Histone Deacetylase Inhibitors Research
- Sepsis Diagnosis and Treatment
- Platelet Disorders and Treatments
- Plant Micronutrient Interactions and Effects
First Affiliated Hospital of Jinan University
2020-2025
Nanjing University of Chinese Medicine
2023-2025
Guizhou University
2009-2025
Shandong Maternal and Child Health Hospital
2017-2025
Shandong First Medical University
2024-2025
Nanjing Drum Tower Hospital
2022-2025
Jiangsu Vocational College of Medicine
2025
Wuhan Pulmonary Hospital
2022-2025
Nanjing University
2024
Huashan Hospital
2024
Prior randomized trials have generally shown harm or no benefit of stenting added to medical therapy for patients with symptomatic severe intracranial atherosclerotic stenosis, but it remains uncertain as whether refined patient selection and more experienced surgeons might result in improved outcomes.To compare plus vs alone stenosis.Multicenter, open-label, randomized, outcome assessor-blinded trial conducted at 8 centers China. A total 380 transient ischemic attack nondisabling,...
Immunotherapy and radiotherapy play crucial roles in the transformation therapy of locally advanced pancreatic cancer; however, exploration effective predictive biomarkers has been unsatisfactory. With rapid development radiomics, next-generation sequencing, machine learning, there is hope to identify that can predict efficacy transformative treatment for cancer through simple non-invasive clinical methods. Our study focuses on using computed tomography (CT), positron emission...
Abstract To evaluate internal tandem duplication (ITD) insertion sites and length as well their clinical impact in younger adult patients with FLT3-ITD–positive acute myeloid leukemia (AML), sequencing after DNA-based amplification was performed diagnostic samples from 241 FLT3-ITD–mutated patients. All were treated on 3 German-Austrian AML Study Group protocols. Thirty-four of the had more than 1 ITD, leading to a total 282 ITDs; median ITD 48 nucleotides (range, 15-180 nucleotides)....
Abstract Developing chemicals that inhibit checkpoint kinase 1 (Chk1) is a promising adjuvant therapeutic to improve the efficacy and selectivity of DNA‐targeting agents. Reliable prediction binding‐free energy binding affinity Chk1 inhibitors can provide guide for rational drug design. In this study, multiple docking strategies Prime/Molecular Mechanics Generalized Born Surface Area (Prime/MM‐GBSA) calculation were applied predict mode free series benzoisoquinolinones as inhibitors. results...
To evaluate the prognostic impact of minimal residual disease (MRD) in patients with acute myeloid leukemia (AML) expressing CBFB-MYH11 fusion transcript.Quantitative reverse transcriptase polymerase chain reaction (PCR) was performed on 684 bone marrow (BM; n = 331) and/or peripheral blood (PB; 353) samples (median, 13 per patient) from 53 younger adult (16 to 60 years old) AML treated prospective German-Austrian Study Group treatment trials. Samples were obtained at diagnosis (BM, 45; PB,...
Iron (Fe) is an essential micronutrient that participates in various biological processes important for plant growth. Ethylene production induced by Fe deficiency plays roles tolerance to stress deficiency. However, the activation and regulatory mechanisms of 1-Aminocyclopropane-1-carboxylic acid synthase (ACS) genes this response are not clear. In study, we demonstrated increased abundance ACS2, ACS6, ACS7, ACS11 transcripts both leaf root as well ACS8 ACS9 root. Furthermore, investigated...
Tranexamic acid is recommended for reducing blood loss and transfusion in cardiac surgery. However, it remains unknown whether a high dose of tranexamic provides better blood-sparing effect than low without increasing the risk thrombotic complications or seizures surgery.To compare efficacy adverse events high-dose vs low-dose patients undergoing surgery with cardiopulmonary bypass.Multicenter, double-blind, randomized clinical trial among adult bypass. The study enrolled 3079 at 4 hospitals...
Under saline conditions, plant growth is depressed via osmotic stress and salt can accumulate in leaves leading to further depression of due reduced photosynthesis gas exchange. Aquaporins are proposed have a major role plants their impact on root water uptake leaf In this study, soybean plasma membrane intrinsic protein 1;6 (GmPIP1;6) was constitutively overexpressed evaluate the function GmPIP1;6 regulation tolerance soybean.GmPIP1;6 highly expressed roots as well reproductive tissues...
This is a phase II study of PD-1 blockade plus chemoradiotherapy as preoperative therapy for patients with locally advanced or borderline resectable pancreatic cancer (LAPC BRPC, respectively). Twenty-nine are enrolled in the study. The objective response rate (ORR) 60%, and R0 resection 90% (9/10). 12-month progression-free survival (PFS) overall (OS) 64% 72%, respectively. Grade 3 higher adverse events anemia (8%), thrombocytopenia jaundice (8%). Circulating tumor DNA analysis reveals that...
ABSTRACT Our previous study reported that histone deacetylase 4 (HDAC4) expression is significantly downregulated in placental tissues of pre‐eclampsia (PE) pregnancies. Cellular pyroptosis a key event the pathogenesis PE induces release factors into maternal circulation. The aim this to analyze role and related molecular mechanisms HDAC4 trophoblast cell pyroptosis. Hypoxia lipopolysaccharide (LPS)/ATP‐treated immortalized human villous cells HTR‐8/SVneo were utilized mimic state PE. Both...
Abstract Human embryonic stem (hES) cells as a renewable cell source have great prospective applications in both developmental biology research and regenerative medicine. To realize these potentials, the development of effective safe genetic manipulation methods hES is an obvious demand. We report here that baculoviral vectors were able to transduce efficiently. In transient transduction experiments, recombinant vector equipped with human elongation factor 1-α promoter woodchuck hepatitis...
Mitosin (also named CENP-F) is a large human nuclear protein transiently associated with the outer kinetochore plate in M phase. Using RNA interference and fluorescence microscopy, we showed that mitosin depletion attenuated chromosome congression led to metaphase arrest misaligned polar chromosomes whose kinetochores few cold-stable microtubules. Kinetochores of fully aligned often failed show orientation direction spindle long axis. Moreover, tension across their sister was decreased by...
The microtubule-based motor cytoplasmic dynein/dynactin is a force generator at the kinetochore. It also transports proteins away from kinetochores to spindle poles. Regulation of such diverse functions, however, poorly understood. We have previously shown that Nudel critical for dynein-mediated protein transport, whereas mitosin, kinetochore binds Nudel, involved in retention against microtubule-dependent stripping. Here we demonstrate required robust localization localizes after nuclear...