A5100616462- Bladder and Urothelial Cancer Treatments
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Urinary and Genital Oncology Studies
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Epigenetics and DNA Methylation
- Selenium in Biological Systems
- Cancer, Lipids, and Metabolism
- Cardiac electrophysiology and arrhythmias
- Cancer-related gene regulation
- Cardiac Structural Anomalies and Repair
- Multiple and Secondary Primary Cancers
- Renal cell carcinoma treatment
- Esophageal Cancer Research and Treatment
- Viral Infections and Immunology Research
- Cancer-related molecular mechanisms research
- MRI in cancer diagnosis
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Birth, Development, and Health
- Wnt/β-catenin signaling in development and cancer
- Cardiomyopathy and Myosin Studies
Merck & Co., Inc., Rahway, NJ, USA (United States)
2017-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2024
Zhengzhou University
2023-2024
Huazhong University of Science and Technology
2015-2024
Tongji Hospital
2015-2024
Sun Yat-sen University
2012-2024
Ningbo No.6 Hospital
2021-2024
Nanjing Medical University
2022-2024
Changzhou No.2 People's Hospital
2024
Peking Union Medical College Hospital
2017-2024
<h3>Importance</h3> Laparoscopic distal gastrectomy is accepted as a more effective approach to conventional open for early-stage gastric cancer. However, efficacy locally advanced cancer remains uncertain. <h3>Objective</h3> To compare 3-year disease-free survival patients with after laparoscopic or gastrectomy. <h3>Design, Setting, and Patients</h3> The study was noninferiority, open-label, randomized clinical trial at 14 centers in China. A total of 1056 eligible stage T2, T3, T4a without...
The safety of laparoscopic total gastrectomy (LTG) for the treatment gastric cancer remains uncertain given lack high-level clinical evidence.To compare LTG stage I with that conventional open (OTG).The Chinese Laparoscopic Gastrointestinal Surgery Study (CLASS) Group CLASS02 study was a prospective, multicenter, open-label, noninferiority, randomized trial compared vs OTG lymphadenectomy patients cancer. From January 2017 to September 2018, 227 were enrolled. Final follow-up in October...
<h3>Importance</h3> It is not clear whether laparoscopic and open distal gastrectomy produce similar outcomes among patients with locally advanced gastric cancer. Data from a multicenter, randomized clinical trial (Chinese Laparoscopic Gastrointestinal Surgical Study [CLASS]–01) showed that did result in inferior disease-free survival at 3 years compared gastrectomy. <h3>Objective</h3> To report 5-year overall data the CLASS-01 of vs <h3>Design, Setting, Patients</h3> This was...
Background Vitamin D insufficiency is a common public health problem nationwide. Circulating 25-hydroxyvitamin D3 (25[OH]D), the most commonly used index of vitamin status, converted to active hormone 1,25 dihydroxyvitamin (1,25[OH]2D), which, operating through receptor (VDR), inhibits in vitro cell proliferation, induces differentiation and apoptosis, may protect against prostate cancer. Despite intriguing results from laboratory studies, previous epidemiological studies showed inconsistent...
Abstract Oxidative stress may enhance prostatic carcinogenesis. A polymorphism [valine (V) → alanine (A)] of manganese superoxide dismutase (MnSOD), the primary antioxidant enzyme in mitochondria, has been recently associated with prostate cancer. We examined relationship between cancer and MnSOD its interactions baseline plasma levels (selenium, lycopene, α-tocopherol) β-carotene treatment among 567 cases 764 controls nested prospective Physicians' Health Study. found little overall...
Background: Epidemiologic studies suggest that low selenium levels are associated with an increased incidence of prostate cancer, although results conflicting. We examined the association between pre-diagnostic plasma and risk cancer in men enrolled Physicians' Health Study. Methods: Using samples obtained 1982 from healthy study, we conducted a nested case–control study among 586 diagnosed during 13 years follow-up 577 control subjects. Odds ratios (ORs) 95% confidence intervals (CIs) for...
Abstract Background: Animal models suggest that n-3 fatty acids inhibit prostate cancer proliferation, whereas n-6 promote it, but epidemiologic studies do not uniformly support these findings. Methods: A nested case-control study was conducted among 14,916 apparently healthy men who provided blood samples in 1982. Blood acid levels were determined for 476 diagnosed with during a 13-year follow-up and their matched controls. Conditional logistic regression used to estimate the relative risks...
Abstract Background: Adipocytokines may mediate the association between adiposity and lethal prostate cancer outcomes. Methods: In Physicians’ Health Study, we prospectively examined of prediagnostic plasma concentrations adiponectin leptin with risk developing incident (654 cases diagnosed 1982–2000 644 age-matched controls) and, among cases, dying from by 2007. Results: Adiponectin were not associated overall cancer. However, men higher had lower high-grade or (metastatic fatal disease)....
Purpose In the phase III KEYNOTE-045 study ( ClinicalTrials.gov identifier: NCT02256436), pembrolizumab significantly prolonged overall survival compared with investigator's choice of chemotherapy in patients previously treated advanced urothelial cancer. Here, we report results health-related quality-of-life (HRQoL) analyses from trial. Patients and Methods were randomly assigned 1:1 to 200 mg or docetaxel 75 mg/m2, paclitaxel 175 vinflunine 320 mg/m2 administered intravenously every 3...
Abstract Ferroptosis is a form of regulated cell death characterized by iron-dependent accumulation lipid hydroperoxides to lethal levels. YAP has been reported play pivotal role in controlling ferroptotic death, and the expression enhanced stabilized O-GlcNAcylation. However, whether O-GlcNAcylation can increase sensitivity hepatocellular carcinoma (HCC) cells ferroptosis remains unknown. In present study, we found that increased HCC via YAP. Moreover, iron concentration through...
Tranexamic acid is recommended for reducing blood loss and transfusion in cardiac surgery. However, it remains unknown whether a high dose of tranexamic provides better blood-sparing effect than low without increasing the risk thrombotic complications or seizures surgery.To compare efficacy adverse events high-dose vs low-dose patients undergoing surgery with cardiopulmonary bypass.Multicenter, double-blind, randomized clinical trial among adult bypass. The study enrolled 3079 at 4 hospitals...
Abstract The synergistic effect of neoadjuvant immunotherapy and chemoradiotherapy in gastric adenocarcinoma is unclear. This phase II trial (NCT03631615) investigated this combination locally advanced stomach or gastroesophageal junction. Thirty-six patients received capecitabine 850 mg/m 2 twice daily simultaneous radiotherapy for 5 weeks, sandwiched by a 21-day cycle oxaliplatin 130 (day 1) plus 1000 (days 1–14), respectively, followed surgery. Camrelizumab 200 mg was given cycles since...
Abstract Distinguishing aggressive prostate cancer from indolent disease represents an important clinical challenge, as current therapy requires over treating men with to prevent the progression of a few cases. Expression metastasis-associated protein 1 (MTA1) has previously been found be associated metastatic state in various cancers. Analyzing DNA microarray data, we MTA1 selectively overexpressed compared clinically localized and benign tissue. These results were validated by...
Interleukin-6 (IL-6) and C-reactive protein (CRP) are elevated in prostate cancer patients, but the role of prediagnostic levels these inflammatory mediators on outcomes is unclear. We undertook a large, prospective case-control study to evaluate relation between IL-6 CRP incidence mortality. also investigated (-174 G/C) polymorphism circulating CRP, as well risk used unconditional logistic regression that adjusted for matching factors analyze risk. For analyses mortality, we conducted...
Abstract The role of selenium in prostate cancer (PCa) risk remains controversial, but many epidemiologic studies suggest an inverse association with more aggressive disease. A recently discovered selenoprotein, SEP15, which is highly expressed the prostate, may play a either independently or by modifying effects selenium. We genotyped four common single-nucleotide polymorphisms capturing variation (frequency &gt;5%; R2 &gt; 0.8) within as well rs5859 3′ untranslated region,...
Non-alcoholic fatty liver disease (NAFLD) represents a large and growing public health problem. Insulin resistance (IR) plays crucial role in the pathogenesis of NAFLD. The aim this study was to determine association triglyceride-glucose (TyG) index, TyG index with body mass (TyG-BMI), lipid accumulation product (LAP), visceral adiposity (VAI), triglycerides/high-density lipoprotein cholesterol ratio (TG/HDL-c) metabolic score for IR (METS-IR) NAFLD older adults compare discriminatory...
Abstract Background: N-3 fatty acids may decrease risk of colorectal cancer by inhibiting the cyclooxygenase-2 enzyme and production proinflammatory eicosanoids derived from arachidonic acid (20:4n-6). Aspirin also inhibits share with n-3 a potential mechanism to cancer. Methods: We conducted nested case-control analysis using blood samples collected Physicians' Health Study participants in 1982 1984. n-6 levels were measured gas-liquid chromatography for 178 men who developed through...
This study sought to better understand real-world treatment patterns, overall and non-small-cell lung cancer (NSCLC)-specific survival, adverse event (AE) occurrence, economic impact of first-line therapies in Medicare patients.This retrospective cohort identified patients ≥ 65 years the Surveillance, Epidemiology, End Results (SEER)-Medicare linked database who received a first-time advanced (stage IV) NSCLC diagnosis from 2007 2011, platinum-based chemotherapy through mid-2013. First-line...
A large proportion of gastric cancer patients are susceptible to chemoresistance, while the underlying mechanism remains obscure. Stress granules (SGs) play a self-defence role for tumour cells in inhibiting chemotherapy-induced apoptosis. As an SG assembly effector, G3BP1 (Ras-GTPase-activating protein SH3 domain-binding protein) has been reported be overexpressed cancer; thus, here we aim explore its potent roles chemoresistance.Kaplan-Meier analysis was used compare survival rates with...