A5050909868- Neuroblastoma Research and Treatments
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
- Nanoplatforms for cancer theranostics
- Cancer, Hypoxia, and Metabolism
- Ion channel regulation and function
- Peptidase Inhibition and Analysis
- Glycosylation and Glycoproteins Research
- Immune Cell Function and Interaction
- Ubiquitin and proteasome pathways
- CAR-T cell therapy research
- Digestive system and related health
- Cancer Research and Treatments
- Epigenetics and DNA Methylation
- Lipid metabolism and biosynthesis
- Metabolism and Genetic Disorders
- Hippo pathway signaling and YAP/TAZ
- Liver Disease Diagnosis and Treatment
- Protein Degradation and Inhibitors
- T-cell and B-cell Immunology
- Peroxisome Proliferator-Activated Receptors
Shanghai Children's Medical Center
2019-2025
Shanghai Jiao Tong University
2022-2025
Shanghai Clinical Research Center
2023-2024
Abstract Ferroptosis is a form of regulated cell death characterized by iron-dependent accumulation lipid hydroperoxides to lethal levels. YAP has been reported play pivotal role in controlling ferroptotic death, and the expression enhanced stabilized O-GlcNAcylation. However, whether O-GlcNAcylation can increase sensitivity hepatocellular carcinoma (HCC) cells ferroptosis remains unknown. In present study, we found that increased HCC via YAP. Moreover, iron concentration through...
Abstract Hepatoblastoma (HB), the most common pediatric hepatic malignancy, exhibits an increasing incidence. Metabolism reprogramming represents a pivotal hallmark in oncogenic transformation process, with glutamine emerging as critical energy source for neoplastic cells, rivaling glucose. However, mechanism by which is involved development of HB remains unclear. Our study identified metabolism crucial factor HB. The key enzyme metabolism, kidney-type glutaminase (GLS1), activated and...
Abstract Hepatoblastoma, the most aggressive childhood liver tumor, poses significant challenges due to limited knowledge of its pathogenesis, particularly in poorly differentiated advanced tumors where prognosis is dismal. Single‐cell sequencing provides an in‐depth exploration at single‐cell level and offers a deep understanding tumor heterogeneity. Herein, transcriptomics analysis used identify unique malignant‐hepatoblast (HB)‐like cell subpopulation as possible origin hepatoblastoma....
Abstract Background Accumulating studies have shown that La‐related protein 1 (LARP1) is involved in the occurrence and development of various tumours. However, expression pattern biological role LARP1 hepatoblastoma (HB) remain unclear so far. Methods level HB adjacent normal liver tissues was analysed by qRT‐PCR, Western blotting immunohistochemistry assays. The prognostic significance evaluated Kaplan–Meier method multivariate Cox regression analysis. In vitro vivo functional assays were...
Background & AimsHepatoblastoma (HB) is a common pediatric malignant liver tumor that characterized by low level of genetic mutations. Alternative splicing (AS) has been shown to be closely associated with cancer progression, especially in tumors mutational burden. However, the role AS HB remains unknown.MethodsTranscriptome sequencing was performed on 5 pairs tissues and matched non-tumor delineate landscape HB. events were validated 92 samples from 46 patients. RNA pull-down...
IL-27 is an anti-inflammatory cytokine that triggers enhanced antitumor immunity, particularly cytotoxic T lymphocyte responses. In the present study, we sought to develop into a therapeutic adjutant for adoptive cell therapy using our well-established models. We have found directly improved survival status and cytotoxicity of OT-1 CD8+ cells in vitro vivo. Meanwhile, treatment programs memory differentiation cells, characterized by upregulation genes associated with (T-bet, Eomes, Blimp1,...
Ferroptosis has attracted extensive interest from cancer researchers due to its substantial potential as a therapeutic target. The role of LATS2, core component the Hippo pathway cascade, in ferroptosis initiation hepatoblastoma (HB) not yet been investigated. Furthermore, underlying mechanism decreased LATS2 expression remains largely unknown. In present study, we demonstrated HB and that overexpression inhibits cell proliferation by inducing ferroptosis. Increased reduced glycine cysteine...
Hepatoblastoma (HB) is the most common paediatric liver malignancy. Dysregulation of small nucleolar RNAs (snoRNAs) a critical inducer tumour initiation and progression. However, association between snoRNAs HB remains unknown. Here, we conducted snoRNA expression profiling in by sequencing identified decreased level SNORA14A, box H/ACA snoRNA, tissues. Low SNORA14A was correlated with PRETEXT stage metastasis patients. Functionally, overexpression suppressed cell proliferation triggered...
Yes-associated protein (YAP), a key transcriptional co-activator associated with cell fate and tumor progression, has been reported to be powerful driver of hepatoblastoma (HB). In this study, we investigated the mechanism underlying oncogenic role YAP in HB.The expression HB tissues was measured through WB qRT-PCR. The IHC IF were performed determine distribution YAP. phase separation proved by living imaging FRAP experiment. effect cells vitro an vivo tested using CCK8, flow cytometry,...
Functional imaging (FI) techniques have revolutionized tumor by providing information on specific functions, such as glycometabolism. However, cells lack unique molecular characteristics at the level and metabolic pathways, resulting in limited differences compared to normal increased background signals from FI. To address this limitation, we developed a novel technique termed proximity-enhanced functional (PEFI) for accurate visualization of tumors. By using "two adjacent chemically labeled...
Abstract Functional imaging (FI) techniques have revolutionized tumor by providing information on specific functions, such as glycometabolism. However, cells lack unique molecular characteristics at the level and metabolic pathways, resulting in limited differences compared to normal increased background signals from FI. To address this limitation, we developed a novel technique termed proximity‐enhanced functional (PEFI) for accurate visualization of tumors. By using “two adjacent...
Abstract Background: The causal relationship between sex hormone-binding globulin (SHBG) and neuroblastoma remains unknown. This study aimed to explore the causality SHBG risk of using bidirectional two-sample Mendelian randomization (MR) study. Methods: Instrumental variables associated with were obtained from genome-wide association (GWAS) European containing 214,989 females 185,221 males UK Biobank. Summary-level data for derived IEU OpenGWAS project 1,627 patients 3,254 controls....
<div>AbstractBackground:<p>The causal relationship between sex hormone-binding globulin (SHBG) and neuroblastoma remains unknown. This study aimed to explore the causality SHBG risk of using bidirectional two-sample Mendelian randomization (MR) study.</p>Methods:<p>Instrumental variables associated with were obtained from genome-wide association (GWAS) European containing 214,989 females 185,221 males UK Biobank. Summary-level data for derived IEU OpenGWAS project...
<p>Supplementary Figure S1 shows the Manhattan plot of SNPs associated with male SHBG levels.</p>
<p>Supplementary Figure S1 shows the Manhattan plot of SNPs associated with male SHBG levels.</p>
<p>Supplementary Figure S2 shows the Manhattan plot of SNPs associated with female SHBG levels.</p>
<p>Supplementary Figure S2 shows the Manhattan plot of SNPs associated with female SHBG levels.</p>