A5101580911- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- Cancer-related molecular mechanisms research
- Kruppel-like factors research
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Gastric Cancer Management and Outcomes
- Cancer Research and Treatments
- Circular RNAs in diseases
- Liver physiology and pathology
- PI3K/AKT/mTOR signaling in cancer
- Monoclonal and Polyclonal Antibodies Research
- Heat shock proteins research
- Toxic Organic Pollutants Impact
- Macrophage Migration Inhibitory Factor
- ATP Synthase and ATPases Research
- Ferroptosis and cancer prognosis
- Protein Tyrosine Phosphatases
- Signaling Pathways in Disease
- Mechanisms of cancer metastasis
Guiyang Medical University
2020-2025
Wuhan Children's Hospital
2023-2025
Fudan University
2015-2024
Shanghai Medical College of Fudan University
2009-2024
Fujian Medical University
2023-2024
Fujian Provincial Cancer Hospital
2024
Sun Yat-sen University
2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Zhongshan Hospital
2024
Ministry of Public Health
2018
Coordinated translation initiation is coupled with cell cycle progression and growth, whereas excessive ribosome biogenesis often lead to tumor transformation survival. Hepatocellular carcinoma (HCC) among the most common aggressive cancers worldwide generally displays inherently high resistance chemotherapeutic drugs. We found that RACK1, receptor for activated C-kinase 1, was highly expressed in normal liver frequently upregulated HCC. Aberrant expression of RACK1 contributed vitro...
Sialyltransferases transfer sialic acid to nascent oligosaccharides and are upregulated in cancer. The inhibition of sialyltransferases is emerging as a potential strategy prevent metastasis several cancers, including ovarian ST3GAL1 sialyltransferase that catalyzes the from cytidine monophosphate-sialic galactose-containing substrates associated with cancer progression chemoresistance. However, function uncertain. Herein, we use qRT-PCR, western blotting, immunohistochemistry assess...
Abstract Gastric cancer remains the third leading cause of cancer-related mortality worldwide, and invasion metastasis gastric represent major reason for its poor prognosis. In this study, we found that loss receptor activated C-kinase 1 (RACK1) promoted by enhancing autocrine IL8 in vitro vivo. microRNA (miRNA; miR) array identified RACK1 modulated expression a series miRNAs, including miR-302 cluster, tumor through miRNA-302c. Moreover, upregulation turn decreased level miRNA-302c induced...
The early diagnosis and intervention of oesophageal squamous cell carcinoma (ESCC) are particularly important because the lack effective therapies poor prognosis. Comprehensive research on ESCC at single-cell level is rare due to need for fresh high-quality specimens obtained from ESD. This study aims systematically describe cellular atlas human intramucosal ESCC.Five paired samples ESCC, para-ESCC tissues endoscopically resected peripheral blood mononuclear cells were adopted scRNA-seq...
CA-125, the most frequently used biomarker for ovarian cancer detection, cannot provide accurate diagnosis due to its poor specificity as it may also increase in many benign gynecological conditions. Thus, reducing false-positive outcomes is urgently needed. Decrease terminal galactosylated N-glycans of serum IgG has been found various malignancies compared healthy controls. Here, this alteration galactosylation was extended be investigated between and conditions with similar elevated CA-125...
Generally, most of ovarian cancer cannot be detected until large scale and remote metastasis occurs, which is the major cause high mortality in cancer. Therefore, it urgent to discover metastasis-related biomarkers for detection its occult stage. Altered glycosylation a universal feature malignancy certain types glycan structures are well-known markers tumor progressions. Thus, this study aimed reveal specific changes N-glycans secretome metastatic We employed quantitative glycomics approach...
A large proportion of gastric cancer patients are susceptible to chemoresistance, while the underlying mechanism remains obscure. Stress granules (SGs) play a self-defence role for tumour cells in inhibiting chemotherapy-induced apoptosis. As an SG assembly effector, G3BP1 (Ras-GTPase-activating protein SH3 domain-binding protein) has been reported be overexpressed cancer; thus, here we aim explore its potent roles chemoresistance.Kaplan-Meier analysis was used compare survival rates with...
The immune microenvironment plays a critical role in tumor biology. molecular profiles of components and related genes are tremendous value for the study primary resistance to checkpoint blockers (ICBs) gastric cancer (GC) serve as prognostic biomarkers predict GC survival. Recent studies have revealed that cell infiltration (ICI) is an indicator survival responsiveness chemotherapy patients. Here, we describe landscape based on ESTIMATE CIBERSORT algorithms help separate into 3 ICI clusters...
Hepatocellular carcinoma (HCC) is the most common form of hepatic malignancies. The diagnosis HCC remains challenging due to low sensitivity and specificity diagnostic method. Exosomes, which are abundant in various proteins from parent cells, play pivotal roles intercellular communication have been confirmed as promising sources disease biomarkers. Herein, we performed a simple but robust proteomic profiling on exosomes derived 1 μL serum using data-independent acquisition (DIA) method for...
Ras-GTPase-activating protein SH3 domain-binding 1 (G3BP1) is a downstream effector of Ras signalling, and overexpressed in several types human malignancy. However, its role gastric cancer remains unclear. The aim this study was to investigate the prognostic significance G3BP1 cancer.G3BP1 mRNA levels paired frozen tumour samples were detected by real-time polymerase chain reaction western blotting, respectively. Paraffin-embedded used for immunohistochemistry. Gastric cells detect...
Gastric cancer is an important health problem, being the fifth most common and third leading cause of cancer-related death worldwide. Aberrant protein translation contributes to oncogenesis development cancers, upregulation initiation factor eIF4A1 has been observed in several kinds malignancies. However, role gastric progression remains unclear. In this study, we found that expression eIF4A1, a component complex, was increased cancer. High positively associated with poor tumor...
Acute kidney injury (AKI) is a common critical clinical disease with high morbidity and mortality rates. Ischemia-reperfusion (IR) the main cause of AKI, there no effective treatment or prevention. Therefore, it to screen for therapeutic agents find targets. DKS26 derivative oleanolic acid (OA) optimized bioavailability while retaining anti-inflammatory, antioxidant, anti-apoptotic properties OA. This study aimed investigate effects on AKI its underlying molecular mechanisms. We established...
Heat shock protein (Hsp) 60 elicits a potent proinflammatory response in the innate immune system and has been proposed as danger signal of stressed or damaged cells to system. Previous studies reported CD14, TLR2, TLR4 mediators signaling but probably not binding. Although receptor for Hsp60 was be saturable specific on macrophages, it is well defined. In current study, we found that lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), Hsp60, could bind internalize via C...
Liver fibrosis represents the consequences of a sustained wound healing response to chronic liver injuries, and its progression toward cirrhosis is major cause liver-related morbidity mortality worldwide. However, anti-fibrotic treatment remains an unconquered area for drug development. Accumulating evidence indicate that oxidative stress plays critical role in fibrogenesis. In this study, we found PQQ, natural anti-oxidant present wide variety human foods, exerted potent ROS-scavenging...
Mitogen-activated protein kinase kinases are an important part of evolutionary conserved signaling modules that involved in a variety cellular processes response to environmental stimuli. Among them, mitogen-activated 2 (MEK2) is the most crucial upstream pathway ERK1/2 cascade as therapeutic target for overcoming Ras-driven cancers. However, mechanisms MEK2 regulation during tumor progression remain not fully elucidated. Herein, we identified was post-translationally regulated by...
Abstract Lung adenocarcinoma (LUAD) is one of the most common types cancer and has a low survival rate. β-1,4-N-Acetyl galactosaminyltransferase 1 (B4GALNT1), which involved in synthesis complex gangliosides, highly expressed progression various cancers. This study aimed to elucidate biological functions B4GALNT1 LUAD metastasis. We observed that overexpression showed enhanced cell migration invasion vitro, promoted tumor metastasis, with reduced mice. Mechanistically, regulated metastatic...