A5100749939- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Acute Myeloid Leukemia Research
- RNA Research and Splicing
- Zebrafish Biomedical Research Applications
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Traditional Chinese Medicine Analysis
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Renal Diseases and Glomerulopathies
- Metabolomics and Mass Spectrometry Studies
- Angiogenesis and VEGF in Cancer
- Ginseng Biological Effects and Applications
- Metal complexes synthesis and properties
- Pluripotent Stem Cells Research
- Chronic Myeloid Leukemia Treatments
- Lung Cancer Research Studies
- Aquaculture disease management and microbiota
- Metastasis and carcinoma case studies
- Anorectal Disease Treatments and Outcomes
- Advanced biosensing and bioanalysis techniques
Boston Children's Hospital
2018-2025
Beijing Shijitan Hospital
2020-2025
Capital Medical University
2020-2025
Howard Hughes Medical Institute
2018-2025
Guangzhou Panyu Polytechnic
2025
Chinese PLA General Hospital
2024-2025
Dalian Medical University
2017-2024
First Affiliated Hospital of Dalian Medical University
2017-2024
Second Hospital of Hebei Medical University
2013-2024
Hebei Medical University
2013-2024
Translational regulation plays an important role in gene expression and function. Although the transcriptional dynamics of mouse preimplantation embryos have been well characterized, global mRNA translation landscape master regulators zygotic genome activation (ZGA) remain unknown. Here, by developing applying a low-input ribosome profiling (LiRibo-seq) technique, we profiled revealed translational during development. We identified marked transition from MII oocytes to zygotes demonstrated...
Angiogenesis, a process that newly-formed blood vessels sprout from pre-existing ones, is vital for vertebrate development and adult homeostasis. Previous studies have demonstrated the neuronal guidance molecule netrin-1 participates in angiogenesis morphogenesis of vascular system. Netrin-1 exhibits dual activities angiogenesis: either promoting or inhibiting angiogenesis. The anti-angiogenic activity mediated by UNC5B receptor. However, how promotes remained unclear. Here we report CD146,...
// Juan Li 1 , Chun-Xia Zhang Yi-Mei Liu Ke-Li Chen and Gang 1, 2 Key Laboratory of Ministry Education on Traditional Chinese Medicine Resource Compound Prescription, Hubei University Medicine, Wuhan 430065, Hubei, China College Jingzhou 434020, Correspondence to: Chen, email: 250149875@qq.com Keywords: resveratrol, caloric restriction, SIRT1, aging Received: June 12, 2017 Accepted: July 25, Published: August 09, 2017 ABSTRACT Resveratrol restriction (CR) are...
In vertebrates, embryonic hematopoietic stem and progenitor cells (HSPCs) are derived from a subset of endothelial cells, the hemogenic endothelium (HE), through endothelial-to-hematopoietic transition (EHT). Notch signaling is essential for HSPC development during embryogenesis across vertebrates. However, whether how it regulates EHT remains unclear. Here, we show that G protein-coupled receptor 183 (Gpr183) serves as an indispensable switch emergence by repressing before onset EHT....
Maternal H3K27me3–mediated imprinting switches to allelic DNA methylation maintain imprinted expression in extraembryonic cells.
Inherent complexity of plant metabolites necessitates the use multi-dimensional information to accomplish comprehensive profiling and confirmative identification. A dimension-enhanced strategy, by offline two-dimensional liquid chromatography/ion mobility-quadrupole time-of-flight mass spectrometry (2D-LC/IM-QTOF-MS) enabling four-dimensional separations (2D-LC, IM, MS), is proposed. In combination with in-house database-driven automated peak annotation, this strategy was utilized...
Abstract The establishment of naive pluripotency is a continuous process starting with the generation inner cell mass (ICM) that then differentiates into epiblast (EPI). Recent studies have revealed key transcription factors (TFs) for ICM formation, but which TFs initiate EPI specification remains unknown. Here, using targeted rapid protein degradation system, we show GABPA not only regulator major ZGA, also master specifier required by regulating 47% genes during E3.5 to E4.5 transition....
Abstract Objective The study aimed to conduct a bibliometric analysis of mucosal immunity in IgA nephropathy (IgAN) and indicate its current status, hot sopts, direction future studies. Methods literature data was collected from the Web Science Core Collection. CiteSpace 6.1.R3 employed visualization nephropathy, including authors, countries, journals, keywords, organizations, references, bursts keywords timeline keyword clusters reference clusters. Results A total 315 publications 1990 2022...
Protein turnover of Patched, the Hedgehog receptor and key negative regulator signaling, is controlled by ubiquitin E3 ligase, Smurf, in a manner that depends on activation signal transducer, Smoothened.
The risk factors related to polycystic ovary syndrome (PCOS) patients complicated with non-alcoholic fatty liver disease (NAFLD) were investigated. A total of 188 PCOS treated in Shengli Oilfield Central Hospital (Dongying, China) from February 2014 2015 retrospectively analyzed as group, and group was further divided into NAFLD non-NAFLD (N-NAFLD) according the B ultrasound. In same time-period, 65 healthy people selected normal control group. differences clinical, biochemical metabolic...
Notch signaling plays a crucial role in controling the proliferation and differentiation of stem progenitor cells during embryogenesis or organogenesis, but its regulation is incompletely understood. BLOS2, encoded by Bloc1s2 gene, shared subunit two lysosomal trafficking complexes, biogenesis lysosome-related organelles complex-1 (BLOC-1) BLOC-1-related complex (BORC). Bloc1s2−/− mice were embryonic lethal exhibited defects cortical development hematopoiesis. Loss BLOS2 resulted elevated...