Michael F. Leitzmann

ORCID: 0000-0002-0371-2789
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Research Areas
  • Nutritional Studies and Diet
  • Physical Activity and Health
  • Cancer Risks and Factors
  • Obesity, Physical Activity, Diet
  • Nutrition and Health in Aging
  • Cancer, Lipids, and Metabolism
  • Cancer survivorship and care
  • Diet and metabolism studies
  • Childhood Cancer Survivors' Quality of Life
  • Liver Disease Diagnosis and Treatment
  • Health and Medical Studies
  • Colorectal Cancer Screening and Detection
  • Nutrition, Genetics, and Disease
  • Metabolism, Diabetes, and Cancer
  • Gallbladder and Bile Duct Disorders
  • Behavioral Health and Interventions
  • Antioxidant Activity and Oxidative Stress
  • Health Promotion and Cardiovascular Prevention
  • Genetic Associations and Epidemiology
  • Health disparities and outcomes
  • Prostate Cancer Diagnosis and Treatment
  • Alcohol Consumption and Health Effects
  • Mobile Health and mHealth Applications
  • Ovarian cancer diagnosis and treatment
  • Body Composition Measurement Techniques

University of Regensburg
2016-2025

University Hospital Regensburg
2015-2025

Inserm
2025

Klinik und Poliklinik für Kinder- und Jugendmedizin
2024

Kinderklinik Regensburg
2024

John Wiley & Sons (United States)
2023

Hudson Institute
2023

University Hospital Bonn
2022

German Center for Neurodegenerative Diseases
2022

University of Cambridge
2007-2021

Objectives To describe new WHO 2020 guidelines on physical activity and sedentary behaviour. Methods The were developed in accordance with protocols. An expert Guideline Development Group reviewed evidence to assess associations between behaviour for an agreed set of health outcomes population groups. assessment used systematically updated recent relevant systematic reviews; primary reviews addressed additional or subpopulations. Results address children, adolescents, adults, older adults...

10.1136/bjsports-2020-102955 article EN cc-by British Journal of Sports Medicine 2020-11-25

Obesity, defined by a body-mass index (BMI) (the weight in kilograms divided the square of height meters) 30.0 or more, is associated with an increased risk death, but relation between overweight (a BMI 25.0 to 29.9) and death has been questioned.We prospectively examined from any cause 527,265 U.S. men women National Institutes Health-AARP cohort who were 50 71 years old at enrollment 1995-1996. was calculated self-reported height. Relative risks 95 percent confidence intervals adjusted for...

10.1056/nejmoa055643 article EN New England Journal of Medicine 2006-08-22
Iris M. Heid Anne Jackson Joshua C. Randall Thomas W. Winkler Lu Qi and 95 more Valgerður Steinthórsdóttir Guðmar Þorleifsson M. Carola Zillikens Elizabeth K. Speliotes Reedik Mägi Tsegaselassie Workalemahu Charles C. White Nabila Bouatia‐Naji Tamara B. Harris Sonja I. Berndt Erik Ingelsson Cristen J. Willer Michael N. Weedon Jian’an Luan Sailaja Vedantam Tõnu Esko Tuomas O. Kilpeläinen Zoltán Kutalik Shengxu Li Keri L. Monda Anna Dixon Chris Holmes Lee M. Kaplan Liming Liang Josine L. Min Miriam F. Moffatt Cliona Molony Geoffrey C. Nicholson Eric E. Schadt Krina T. Zondervan Mary F. Feitosa Teresa Ferreira Hana Lango Allen Robert J. Weyant Eleanor Wheeler Andrew R. Wood Karol Estrada Michael E. Goddard Guillaume Lettre Massimo Mangino Dale R. Nyholt Shaun Purcell Albert V. Smith Peter M. Visscher Jian Yang Steven A. McCarroll James Nemesh Benjamin F. Voight Devin Absher Najaf Amin Thor Aspelund Lachlan Coin Nicole L. Glazer Caroline Hayward Nancy L. Heard‐Costa Jouke‐Jan Hottenga Åsa Johansson Toby Johnson Marika Kaakinen Karen Kapur Shamika Ketkar Joshua W. Knowles Peter Kraft Aldi T. Kraja Claudia Lamina Michael F. Leitzmann Barbara McKnight Andrew P. Morris Ken K. Ong John R. B. Perry Marjolein J. Peters Ozren Polašek Inga Prokopenko Nigel W. Rayner Samuli Ripatti Fernando Rivadeneira Neil R. Robertson Serena Sanna Ulla Sovio Ida Surakka Alexander Teumer S. van Wingerden Véronique Vitart Wei Zhao Christine Cavalcanti-Proença Peter S. Chines Eva Fisher Jennifer R. Kulzer Cécile Lecœur Narisu Narisu Camilla H. Sandholt Laura J. Scott Kaisa Silander Klaus Stark Mari‐Liis Tammesoo

10.1038/ng.685 article EN Nature Genetics 2010-10-10

The aim of this paper is to review the evidence association between energy balance and obesity. In December 2015, International Agency for Research on Cancer (IARC), Lyon, France convened a Working Group international experts regarding obesity, with focus Low Middle Income Countries (LMIC). global epidemic obesity double burden, in LMICs, malnutrition (coexistence undernutrition overnutrition) are both related poor quality diet unbalanced intake. Dietary patterns consistent traditional...

10.1007/s10552-017-0869-z article EN cc-by Cancer Causes & Control 2017-02-16

High intakes of red or processed meat may increase the risk mortality. Our objective was to determine relations red, white, and for total cause-specific mortality.The study population included National Institutes Health-AARP (formerly known as American Association Retired Persons) Diet Health Study cohort half a million people aged 50 71 years at baseline. Meat intake estimated from food frequency questionnaire administered Cox proportional hazards regression models hazard ratios (HRs) 95%...

10.1001/archinternmed.2009.6 article EN Archives of Internal Medicine 2009-03-23

Background: In small, short-term studies, acute administration of caffeine decreases insulin sensitivity and impairs glucose tolerance. Objective: To examine the long-term relationship between consumption coffee other caffeinated beverages incidence type 2 diabetes mellitus. Design: Prospective cohort study. Setting: The Nurses' Health Study Professionals' Follow-up Study. Participants: authors followed 41 934 men from 1986 to 1998 84 276 women 1980 1998. These participants did not have...

10.7326/0003-4819-140-1-200401060-00005 article EN Annals of Internal Medicine 2004-01-06

Inconsistent findings from observational studies have continued the controversy over effects of dietary fiber on colorectal cancer.To evaluate association between intake and risk cancer.From 13 prospective cohort included in Pooling Project Prospective Studies Diet Cancer, 725,628 men women were followed up for 6 to 20 years across studies. Study- sex-specific relative risks (RRs) estimated with Cox proportional hazards model subsequently pooled using a random-effects model.Incident...

10.1001/jama.294.22.2849 article EN JAMA 2005-12-13

<h3>Background</h3> Whether national physical activity recommendations are related to mortality benefit is incompletely understood. <h3>Methods</h3> We prospectively examined guidelines in relation among 252 925 women and men aged 50 71 years the National Institutes of Health–American Association Retired Persons (NIH-AARP) Diet Health Study. Physical was assessed using 2 self-administered baseline questionnaires. <h3>Results</h3> During 1 265 347 person-years follow-up, 7900 participants...

10.1001/archinte.167.22.2453 article EN Archives of Internal Medicine 2007-12-10

Rates of esophageal adenocarcinoma and gastric cardia have increased, while rates squamous cell carcinoma (ESCC) noncardia decreased, suggesting distinct etiologies. The authors prospectively investigated the associations alcohol tobacco with these cancers in 474,606 US participants using Cox models adjusted for potential confounders. Between 1995/1996 2000, 97 incident cases ESCC, 205 adenocarcinoma, 188 cardia, 187 cancer occurred. Compared nonsmokers, current smokers were at increased...

10.1093/aje/kwm051 article EN American Journal of Epidemiology 2007-03-10

Statins are commonly used cholesterol-lowering drugs that have proapoptotic and antimetastatic activities could affect cancer risk or progression. Results from previous epidemiologic studies of the association between statin use been inconsistent. We investigated with total advanced prostate cancer, latter being most important endpoint to prevent.We analyzed data an ongoing prospective cohort study 34,989 US male health professionals who were free in 1990 followed 2002. Participants reported...

10.1093/jnci/djj499 article EN JNCI Journal of the National Cancer Institute 2006-12-19

Abstract BACKGROUND. Adiposity has been linked inconsistently with prostate cancer, and few studies have evaluated whether such associations vary by disease aggressiveness. METHODS. The authors prospectively examined body mass index (BMI) adult weight change in relation to cancer incidence mortality 287,760 men ages 50 years 71 at enrollment (1995–1996) the National Institutes of Health‐AARP Diet Health Study. At baseline, participants completed questionnaires regarding height, weight,...

10.1002/cncr.22443 article EN public-domain Cancer 2007-01-08

<h3>Background</h3> Obesity is a risk factor for postmenopausal breast cancer, but the role of timing and amount adult weight change in cancer unclear. <h3>Methods</h3> We prospectively examined relations adiposity to among 99 039 women National Institutes Health–AARP Diet Health Study. Anthropometry was assessed by self-report 1996. Through 2000, 2111 incident cases were ascertained. <h3>Results</h3> Current body mass index (BMI) (calculated as kilograms divided height meters squared), BMI...

10.1001/archinte.167.19.2091 article EN Archives of Internal Medicine 2007-10-22

At present, only three risk factors for prostate cancer have been firmly established; these are all nonmodifiable: age, race, and a positive family history of cancer. However, numerous modifiable also implicated in the development In current review, we summarize epidemiologic data location, selected behavioral relation to onset Although available not entirely consistent, possible preventative include increased physical activity, intakes tomatoes, cruciferous vegetables, soy. Factors that may...

10.2147/clep.s16747 article EN cc-by-nc Clinical Epidemiology 2012-01-01

In July, 2019, the World Health Organization (WHO) commenced work to update 2010 Global Recommendations on Physical Activity for and established a Guideline Development Group (GDG) comprising expert public health scientists practitioners inform drafting of 2020 Guidelines Sedentary Behavior. The overall task GDG was review scientific evidence provide advice WHO amount physical activity sedentary behavior associated with optimal in children adolescents, adults, older adults (> 64 years), also...

10.1186/s12966-020-01042-2 article EN cc-by International Journal of Behavioral Nutrition and Physical Activity 2020-11-26

Epidemiologic studies of pancreatic cancer risk have reported null or nonsignificant positive associations for obesity, while height been null. Waist and hip circumference evaluated infrequently. A pooled analysis 14 cohort on 846,340 individuals was conducted; 2,135 were diagnosed with during follow-up. Study-specific relative risks (RRs) 95% confidence intervals (CIs) calculated by Cox proportional hazards models, then using a random effects model. Compared to body mass index (BMI) at...

10.1002/ijc.25794 article EN International Journal of Cancer 2010-11-24

Objectives Latent class trajectory modelling (LCTM) is a relatively new methodology in epidemiology to describe life-course exposures, which simplifies heterogeneous populations into homogeneous patterns or classes. However, for given dataset, it possible derive scores of different models based on number classes, model structure and property. Here, we rationalise systematic framework ‘core’ favoured model. Methods We developed an eight-step framework: step 1: scoping model; 2: refining the...

10.1136/bmjopen-2017-020683 article EN cc-by BMJ Open 2018-07-01
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