Klaus Stark
A5067383632- Genetic Associations and Epidemiology
- Metabolomics and Mass Spectrometry Studies
- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- RNA modifications and cancer
- Renal Diseases and Glomerulopathies
- Hepatitis B Virus Studies
- Hepatitis C virus research
- HIV, Drug Use, Sexual Risk
- Cardiac electrophysiology and arrhythmias
- Chronic Kidney Disease and Diabetes
- Lipid metabolism and disorders
- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- HIV/AIDS Research and Interventions
- Hepatitis Viruses Studies and Epidemiology
- Genetic Mapping and Diversity in Plants and Animals
- Viral Infections and Vectors
- Genetic and phenotypic traits in livestock
- Glaucoma and retinal disorders
- Birth, Development, and Health
- Lipoproteins and Cardiovascular Health
- Liver Disease Diagnosis and Treatment
- COVID-19 epidemiological studies
- RNA Research and Splicing
University of Regensburg
2016-2025
University Hospital Regensburg
2008-2021
Robert Koch Institute
2004-2021
Karolinska Institutet
2012-2016
University of Leicester
2008-2011
NIHR Leicester Cardiovascular Biomedical Research Unit
2011
National Institute for Health Research
2011
University of Glasgow
2011
Cardiovascular Research Center
2011
University of Lübeck
2008
Abstract Clinical criteria for the classification of symptomatic idiopathic (primary) osteoarthritis (OA) hands were developed from data collected in a multi‐center study. Patients with OA compared group patients who had hand symptoms other causes, such as rheumatoid arthritis and spondylar‐thropathies. Variables medical history, physical examination, laboratory tests, radiographs analyzed. All pain, aching, or stiffness hands. classified having clinical if on examination there was hard...
Dilated cardiomyopathy (DCM) is a major cause of heart failure with high familial recurrence risk. So far, the genetics DCM remains largely unresolved. We conducted first genome-wide association study (GWAS) to identify loci contributing sporadic DCM. One thousand one hundred and seventy-nine patients 1108 controls contributed discovery phase. Pools DNA stratified on disease status, population, age, gender were constituted used for testing 517 382 single nucleotide polymorphisms (SNPs)....
Background.Hepatitis E is a classic water-borne disease in developing countries.In Germany, hepatitis virus (HEV) infections are notifiable.The number of non-travel-associated has increased recent years, but the route transmission most unknown.Our objective was to determine risk factors for autochthonous HEV Germany.Methods.Cases met clinical definitions and were confirmed by laboratory analysis (defined as detection polymerase chain reaction [PCR] or immunoglobulin M serologic testing).PCR...
Background Early repolarization pattern (ERP) on electrocardiogram was associated with idiopathic ventricular fibrillation and sudden cardiac arrest in a case-control study cardiovascular mortality Finnish community-based sample. We sought to determine ERP prevalence its association all-cause large, prospective, population-based case-cohort (Monitoring of Cardiovascular Diseases Conditions [MONICA]/KORA [Cooperative Health Research the Region Augsburg]) comprised individuals Central-European...
Background— Phytosterols are plant-derived sterols that taken up from food and can serve as biomarkers of cholesterol uptake. Serum levels under tight genetic control. We used a genomic approach to study the molecular regulation serum phytosterol potential links coronary artery disease (CAD). Methods Results— A genome-wide association for phytosterols (campesterol, sitosterol, brassicasterol) was conducted in population-based sample KORA (Cooperative Research Region Augsburg) (n=1495) with...
Rare mutations of the low-density lipoprotein receptor gene (LDLR) cause familial hypercholesterolemia, which increases risk for coronary artery disease (CAD). Less is known about implications common genetic variation in LDLR regarding variability cholesterol levels and CAD.
Recent genome-wide association (GWA) studies identified 10 chromosomal loci for coronary artery disease (CAD) or myocardial infarction (MI). However, these explain only a small proportion of the genetic variability pertinent diseases. We sought to identify additional CAD/MI by applying three-stage approach.We genotyped n = 1157 MI cases and 1748 controls from population-based study population [German Family Study (GerMIFS) III (KORA)] with SNP arrays. At this first stage, 462 SNPs showed at...
Dilated cardiomyopathy (DCM) is a structural heart disease with strong genetic background. Monogenic forms of DCM are observed in families mutations located mostly genes encoding and sarcomeric proteins. However, evidence suggests that factors also affect the susceptibility to idiopathic DCM. To identify risk alleles for non-familial DCM, we carried out case-control association study, genotyping 664 cases 1,874 population-based healthy controls from Germany using 50K human cardiovascular...
Aims Dilated cardiomyopathy (DCM) is an important cause of heart failure with a strong familial component. We performed exome-wide array-based association study (EWAS) to assess the contribution missense variants sporadic DCM. Methods and results 116,855 single nucleotide (SNVs) were analyzed in 2796 DCM patients 6877 control subjects from 6 populations European ancestry. confirmed two previously identified associations SNVs BAG3 ZBTB17 discovered six novel DCM-associated loci...
Our objective was to better understand the genetic bases of dilated cardiomyopathy (DCM), a leading cause systolic heart failure.