Matthias Olden
A5027856684- Genetic Associations and Epidemiology
- Renal and related cancers
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Nutrition, Genetics, and Disease
- Chronic Kidney Disease and Diabetes
- Epigenetics and DNA Methylation
- Renal Diseases and Glomerulopathies
- Obesity, Physical Activity, Diet
- Birth, Development, and Health
- Genetic Mapping and Diversity in Plants and Animals
- Blood Coagulation and Thrombosis Mechanisms
- Glaucoma and retinal disorders
- Cardiovascular Health and Disease Prevention
- Genetic and phenotypic traits in livestock
- Genetics and Physical Performance
- User Authentication and Security Systems
- Diabetes and associated disorders
- Mobile Health and mHealth Applications
- Liver Disease Diagnosis and Treatment
- Health, Environment, Cognitive Aging
- Pregnancy and preeclampsia studies
- Privacy, Security, and Data Protection
- Cardiovascular Function and Risk Factors
- Ethics in Clinical Research
University of Regensburg
2011-2024
Framingham Heart Study
2013-2017
National Heart Lung and Blood Institute
2013-2014
University Hospital Regensburg
2012-2013
The Christie NHS Foundation Trust
2012
University Medical Center
2010
Elevated concentrations of albumin in the urine, albuminuria, are a hallmark diabetic kidney disease and associated with an increased risk for end-stage renal cardiovascular events. To gain insight into pathophysiological mechanisms underlying we conducted meta-analyses genome-wide association studies independent replication up to 5,825 individuals European ancestry diabetes 46,061 without diabetes, followed by functional studies. Known associations variants CUBN, encoding cubilin, urinary...
The authors investigated the relations of body mass index at different ages and adult weight change to incident colorectal cancer risk in prospective National Institutes Health-AARP Diet Health Study (1995-1996), using a subcohort with repeated recall weights (273,679 participants; mean baseline age = 62.8 years). During 2,509,662 person-years follow-up, 4076 cancers were ascertained. For men, an increased colon but not rectal was associated (per 5-kg/m(2) increase, hazard ratio (HR) 1.18,...
Abstract Genome-wide association studies (GWAS) for late stage age-related macular degeneration (AMD) have identified 52 independent genetic variants with genome-wide significance at 34 genomic loci. Typically, such an approach rarely results in the identification of functional implicating a defined gene disease process. We now performed transcriptome-wide study (TWAS) allowing prediction effects AMD-associated on expression. The TWAS was based genotypes 16,144 late-stage AMD cases and...
In conducting genome-wide association studies (GWAS), analytical approaches leveraging biological information may further understanding of the pathophysiology clinical traits. To discover novel associations with estimated glomerular filtration rate (eGFR), a measure kidney function, we developed strategy for integrating prior knowledge into existing GWAS data eGFR from CKDGen Consortium. Our focuses on single nucleotide polymorphism (SNPs) in genes that are connected by functional evidence,...
Abstract While age-related macular degeneration (AMD) poses an important personal and public health burden, comparing epidemiological studies on AMD is hampered by differing approaches to classify AMD. In our AugUR study survey, recruiting residents from in/around Regensburg, Germany, aged 70+, we analyzed the status derived color fundus images applying two different classification systems. Based 1,040 participants with gradable for at least one eye, show that including individuals only eye...
Age-related macular degeneration (AMD) is a vision impairing disease of the central retina characterized by early and late forms in individuals older than 50 years age. However, there little knowledge to what extent also younger adults are affected. We have thus set out estimate prevalence AMD features general adult population acquiring color fundus images 2,840 aged 25 74 Cooperative Health Research Region Augsburg project (KORA) South Germany. Among 2,546 participants with gradable for...
Low socioeconomic status (SES) is associated with increased mortality from cardiovascular disease, cancer and trauma. However, individual-level prospective data on SES in relation to health outcomes among critically ill patients admitted intensive care units (ICU) are unavailable.In a cohort of 1,006 at 24-bed surgical ICU an academic tertiary facility Germany, we examined levels disease severity admission, time period mechanical ventilation, length stay frequency phone calls visits by...
Introduction and Aims: Chronic kidney disease (CKD) is a significant public health problem of increasing prevalence. Previous studies support genetic contribution to CKD. We therefore aimed identify risk variants for CKD reduced estimated glomerular filtration rate (eGFR) using genome-wide association in the CKDGen Consortium. Methods: Data from 67,093 Caucasian participants 20 population-based (AGES, Amish, ARIC, ASPS, BLSA, CHS, ERF, FamHS, FHS, KORA, Korcula, Micros, Orcades, NSPHS, RS,...
Background The proximal aorta normally functions as a critical shock absorber that protects small downstream vessels from damage by pressure and flow pulsatility generated the heart during systole. This function is impaired with age because of aortic stiffening. Methods Results We examined contribution common genetic variation to stiffness in humans interrogating results AortaGen Consortium genome‐wide association study carotid‐femoral pulse wave velocity. Common N‐ WASP ( WASL ) locus...
Creating study identifiers and assigning them to participants is an important feature in epidemiologic studies, ensuring the consistency privacy of data. The numbering system for needs be random within certain number constraints, carry extensions coding organizational information, or contain multiple layers numbers per participant diversify data access. Available software can generate globally-unique identifiers, but identifier-creating tools meeting special epidemiological studies are...