A5001900750- Acute Myocardial Infarction Research
- Cardiovascular Function and Risk Factors
- Chronic Disease Management Strategies
- Blood Pressure and Hypertension Studies
- Heart Failure Treatment and Management
- Nutritional Studies and Diet
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Promotion and Cardiovascular Prevention
- Metabolism, Diabetes, and Cancer
- Cardiac Imaging and Diagnostics
- Diet and metabolism studies
- Climate Change and Health Impacts
- Cardiovascular Disease and Adiposity
- Pain Mechanisms and Treatments
- Health and Medical Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes Management and Research
- Liver Disease Diagnosis and Treatment
- Health disparities and outcomes
- Botulinum Toxin and Related Neurological Disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiac Health and Mental Health
- Diabetes Treatment and Management
- Nutrition and Health in Aging
- Cardiac Arrest and Resuscitation
Helmholtz Zentrum München
2016-2025
University Hospital Augsburg
2016-2025
Center for Environmental Health
2008-2025
German Center for Diabetes Research
2018-2024
Heinrich Heine University Düsseldorf
2009-2024
Deutsches Diabetes-Zentrum e.V.
2009-2024
Körber Foundation
2022
Institute of Bioinformatics and Systems Biology
2020
Hochschule Düsseldorf University of Applied Sciences
2018
Augsburg University
2006-2015
An association between exposure to vehicular traffic in urban areas and the exacerbation of cardiovascular disease has been suggested previous studies. This study was designed assess whether can trigger myocardial infarction.We conducted a case-crossover which cases infarction were identified with use data from Cooperative Health Research Region Augsburg Myocardial Infarction Registry Augsburg, southern Germany, for period February 1999 July 2001. There 691 subjects whom date time known who...
Although the prevalence of celiac disease (CD) has been extensively investigated in recent years, an accurate estimate CD frequency European population is still lacking. The aims this study were: 1) to establish accurately a large sample (Finland, Germany, Italy, and UK), including both children adults; 2) investigate whether significantly varies between different areas continent.Samples were drawn from four populations. All 29,212 participants tested for by tissue transglutaminase (tTG)...
Not all obese subjects have an adverse metabolic profile predisposing them to developing type 2 diabetes or cardiovascular disease. The BioSHaRE-EU Healthy Obese Project aims gain insights into the consequences of (healthy) obesity using data on risk factors and phenotypes across several large-scale cohort studies. Aim this study was describe prevalence obesity, syndrome (MetS) metabolically healthy (MHO) in ten participating studies.Ten different cohorts seven countries were combined,...
Multimorbidity is a common problem in aged populations with wide range of individual and societal consequences. The objective the study was to explore patterns comorbidity multimorbidity an elderly population using different analytical approaches. Data were gathered from population-based KORA-Age project, which included 4,127 persons 65-94 years living city Augsburg its two surrounding counties Southern Germany. Information on presence 13 chronic conditions collected standardized telephone...
The validity of survey-based health care utilization estimates in the older population has been poorly researched. Owing to data protection legislation and a great number different insurance providers, assessment recall non-response bias is challenging impossible many countries. objective our study was compare from population-based German adults with external secondary data. We used KORA-Age study, which included 4,127 people aged 65–94 years. Self-report questions covered long-term...
The German National Cohort (NAKO) is a multidisciplinary, population-based prospective cohort study that aims to investigate the causes of widespread diseases, identify risk factors and improve early detection prevention disease. Specifically, NAKO designed novel better characterize established protection for development cardiovascular cancer, diabetes, neurodegenerative psychiatric musculoskeletal respiratory infectious diseases in random sample general population. Between 2014 2019, total...
To examine gender-specific associations between sleep duration and complaints incident myocardial infarction (MI). Cohort study. A representative population sample of middle-aged subjects in Germany. The study was based on 3508 men 3388 women (aged 45 to 74 years) who participated one the 3 MONICA (Monitoring trends determinants cardiovascular diseases) Augsburg surveys 1984 1995, were free MI angina pectoris at baseline followed up until 2002. N/A total 295 cases among 85 occurred during a...
Abstract Aims To determine the incidence of Type 2 diabetes in an elderly population Germany and its association with clinical lifestyle factors. Methods Oral glucose tolerance tests (OGTT, World Health Organization criteria) were carried out a random sample 1353 subjects (age group 55–74 years; 62% response) Augsburg (Southern Germany) (1999–2001). The cohort was re‐investigated 2006–2008. Of those individuals without (baseline), 887 (74%) participated follow‐up. Results Ninety‐three...
To investigate regional variations in the prevalence and management of hypertension two communities north-east south-west Germany.Two population-based surveys men women aged 25-74 years, using a common standardized protocol: Study Health Pomerania (SHIP; 3744 participants) Kooperative Gesundheitsforschung der Region Augsburg (KORA; 4224 participants).Comparison SHIP KORA with regard to mean systolic (SBP) diastolic blood pressure (DBP), hypertension, percentage awareness, treatment control...
Serum metabolites are associated cross-sectionally with kidney function in population-based studies. Using flow injection and liquid chromatography tandem mass spectrometry methods, we examined longitudinal associations of baseline concentrations 140 their 19 460 ratios decline chronic disease (CKD) incidence over 7 years 1104 participants the Cooperative Health Research Region Augsburg S4/F4 study. Corrected for multiple testing, a significant association annual change estimated glomerular...
OBJECTIVE Metformin is used as a first-line oral treatment for type 2 diabetes (T2D). However, the underlying mechanism not fully understood. Here, we aimed to comprehensively investigate pleiotropic effects of metformin. RESEARCH DESIGN AND METHODS We analyzed both metabolomic and genomic data population-based KORA cohort. To evaluate effect metformin on metabolite concentrations, quantified 131 metabolites in fasting serum samples multivariable linear regression models three independent...
Detailed pathophysiological manifestations of early disease in the context prediabetes are poorly understood. This study aimed to evaluate extent signs metabolic and cardio-cerebrovascular complications affecting multiple organs individuals with prediabetes. Subjects without a history stroke, coronary artery disease, or peripheral were enrolled case-control nested within Cooperative Health Research Region Augsburg (KORA) FF4 cohort underwent comprehensive MRI assessment characterize cerebral...
Abstract Aims The association between air temperature and mortality has been shown to vary over time, but evidence of temporal changes in the risk myocardial infarction (MI) is lacking. We aimed estimate variations short-term exposures MI area Augsburg, Germany. Methods results Over a 28-years period from 1987 2014, total 27 310 cases coronary deaths were recorded. Daily meteorological parameters measured study area. A time-stratified case-crossover analysis with distributed lag non-linear...
Experimental and epidemiological studies have implicated inflammatory processes in the pathogenesis of distal sensorimotor polyneuropathy (DSPN), but prospective are lacking. We hypothesized that biomarkers inflammation predict development progression DSPN a population-based cohort.This study was based on participants aged 62-81 years from Cooperative Health Research Region Augsburg (KORA) F4/FF4 cohort, with mean follow-up 6.5 years. The predictive value systemic levels eight assessed for...
Advances in the “omics” field bring about need for a high number of good quality samples. Many omics studies take advantage biobanked samples to meet this need. Most laboratory errors occur pre-analytical phase. Therefore evidence-based standard operating procedures phase as well markers distinguish between ‘good’ and ‘bad’ taking into account desired downstream analysis are urgently needed. We studied concentration changes metabolites serum due pre-storage handling conditions repeated...
The vascular effects of high-density lipoproteins (HDL) differ under certain clinical conditions. composition HDL is modified in patients with chronic kidney disease (CKD). As a consequence, uremic induces endothelial dysfunction. We have previously shown that accumulation symmetric dimethylarginine (SDMA) causes these adverse CKD. aim the study to determine impact SDMA on association between and mortality.Mortality, renal function, serum HDL-cholesterol (HDL-C) were assessed LURIC including...
Prior studies demonstrated an association between hospital admission blood glucose and mortality in acute myocardial infarction (AMI). Because stress hyperglycemia ratio (SHR) has been suggested as a more reliable marker of this study investigated to what extent SHR comparison with is associated short- long-term diabetic non-diabetic AMI patients.The analysis was based on 2,311 patients aged 25-84 years from the population-based Myocardial Infarction Registry Augsburg (median follow-up time...