A5102834745- Tuberculosis Research and Epidemiology
- Breast Cancer Treatment Studies
- Cancer Mechanisms and Therapy
- Cancer Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Infectious Diseases and Tuberculosis
- Metabolomics and Mass Spectrometry Studies
- Cancer-related molecular mechanisms research
- Dietary Effects on Health
- Breast Lesions and Carcinomas
- Cancer Genomics and Diagnostics
- Advanced Breast Cancer Therapies
- Epigenetics and DNA Methylation
- Bacterial Infections and Vaccines
- Abdominal vascular conditions and treatments
- Cancer Risks and Factors
- Biomedical Ethics and Regulation
- Catalysis and Hydrodesulfurization Studies
- Heat shock proteins research
- Cancer-related gene regulation
- Wnt/β-catenin signaling in development and cancer
- Genomics and Rare Diseases
- Otitis Media and Relapsing Polychondritis
- Ferroptosis and cancer prognosis
- Homicide, Infanticide, and Child Abuse
Beijing Chuiyangliu Hospital
2025
Tsinghua University
2025
Second Xiangya Hospital of Central South University
2017-2024
Central South University
2005-2024
Hunan Cancer Hospital
2014-2024
Shandong First Medical University
2021
Shandong Provincial Hospital
2021
Southwest Hospital
2017
Army Medical University
2017
Air Force Medical University
2012-2016
Background Human plasma and serum are widely used matrices in clinical biological studies. However, different collecting procedures the coagulation cascade influence concentrations of both proteins metabolites these matrices. The effects on metabolite concentration profiles have not been fully characterized. Methodology/Principal Findings We analyzed 163 samples collected simultaneously from 377 fasting individuals. To ensure data quality, 41 with low measurement stability were excluded...
OBJECTIVE Metformin is used as a first-line oral treatment for type 2 diabetes (T2D). However, the underlying mechanism not fully understood. Here, we aimed to comprehensively investigate pleiotropic effects of metformin. RESEARCH DESIGN AND METHODS We analyzed both metabolomic and genomic data population-based KORA cohort. To evaluate effect metformin on metabolite concentrations, quantified 131 metabolites in fasting serum samples multivariable linear regression models three independent...
Tuberculous meningitis leads to a devastating outcome, and early diagnosis rapid chemotherapy are vital reduce morbidity mortality. Since Mycobacterium tuberculosis is kind of cytozoic pathogen its numbers very few in cerebrospinal fluid, detecting M. fluid from tuberculous patients still challenge for clinicians. Ziehl-Neelsen stain, the current feasible microbiological method tuberculosis, often needs large amount specimen but shows low detection rate tuberculosis. Here, we developed...
T-cell responses may be shaped by sterile "danger signals" that are constituted damage-associated molecular patterns (DAMP). However, whether and what type of adaptive immune triggered in vivo DAMPs induced tumor progression not well characterized. In this study, we report the production HMGB1, an established DAMP released dying cells, was critical for mouse model prostate cancer. HMGB1 required activation intratumoral accumulation T cells expressed cytokine lymphotoxinα(1)β(2) (LT) on their...
Recent data have shown that the expression of lysosome-associated membrane protein type 2 A (LAMP2A), key in chaperone-mediated autophagy (CMA) pathway, is elevated breast tumor tissues. However, exact effects and mechanisms CMA during cancer metastasis remain largely unknown. In this study, we found LAMP2A level was significantly human tissues, particularly metastatic carcinoma. The increased also positively correlated with histologic grade ductal cancer. High levels predicted shorter...
The administration of doxorubicin (DOX) is one the first‐line treatments breast cancer. However, acquisition resistance remains major obstacle restricting clinical application DOX. MicroRNAs (miRNAs) are small, noncoding RNAs which play crucial role in epigenetic regulation. Recent studies have shown that miRNAs associated with tumor chemoresistance. Here we aim to explore miRNA‐192‐5p DOX cancer cells. Normal human epithelial cell line MCF‐10A, Michigan Cancer Foundation‐7 (MCF‐7), and...
Background. Breast cancer-related depression (BCRD) seriously inhibits the life quality of patients with breast cancer. The Xiaoyao Kangai Jieyu Formula is known to inhibit progression depression. However, detailed function in BCRD remains unclear. Methods. Network pharmacology was constructed assess downstream target BCRD. In addition, tail suspension test, sucrose preference and forced swimming test were used symptom mice. Fluoro-Jade B staining performed observe structure neurons. RT-qPCR...
Viral infection is an important component of the environmental factors that contribute to production autoimmune antibodies and diseases. There considerable evidence COVID-19 patients are more likely develop several types Therefore, some researchers hypothesize may trigger response in genetically susceptible individuals. This article presents a case with tracheobronchomalacia. The possible relationship between pathogenesis tracheobronchial chondritis discussed this article. Respiratory...
Rationale: Early diagnosis and treatment of tuberculous meningitis saves lives, but current laboratory diagnostic tests lack sensitivity.Objectives: We investigated whether the detection intracellular bacteria by a modified Ziehl-Neelsen stain early secretory antigen target (ESAT)-6 in cerebrospinal fluid leukocytes improves diagnosis.Methods: Cerebrospinal specimens from patients with suspected were stained conventional stain, involving cytospin slides Triton processing, an ESAT-6...
MicroRNAs (miRNAs) are a group of small non‑coding RNA molecules, which serve an important function in the development multidrug resistance cancer through post‑transcriptional regulation gene expression and silencing. In present study, functional effects miR‑197 were analyzed chemo‑resistant gastric cells. Low levels observed fluorouracil (5‑FU)‑resistant cell line SGC7901/5‑FU when compared with those parental SGC7901. Overexpression cells was identified to partially restore 5‑FU...
NOD1 and NOD2 have been found to play a significant regulatory role in autoimmune disease. To analyze the of pathogenesis Vogt- Koyanagi-Harada (VKH) syndrome Behcet's disease (BD). We analyzed expression from PBMCs by RT-PCR Western Blot. DCs were cultured with NOD receptor ligands iE-DAP (NOD1) or MDP (NOD2) cells supernatants flow cytometry (FCM) enzyme-linked immunosorbent assay (ELISA). CD4+T co-cultured without stimulation FCM ELISA. A higher was observed patients active VKH as...
Pancreatic cancer is one of the most aggressive tumors with a dismal prognosis. The membrane cytoskeletal crosslinker Ezrin participates in several functions including cell proliferation, adhesion, motility and survival. There increasing evidence that overexpressed vast majority malignant regulates tumor progression. However, its roles pancreatic remain elusive.Three pairs specific siRNAs were designed synthetized screened to determine efficient for construction hairpin RNA plasmid targeting...
Nearly half of metastatic breast cancers (MBC) have genetic aberrations in the PI3K/AKT pathway.To investigate distinct effect these on MBC, 193 MBC patients who progressed after early line (≤2) salvage treatment voluntarily received next generation sequencing (NGS) for a panel 1,021 genes.93 (48%) had pathway.The number with PIK3CA mutations kinase domain (KD), helical (HD) and other (OD), were 36 (18.7%), 26 (13.5%), 10 (5.2%), respectively.21 (10.9%)patients pathway genes than...
Early diagnosis and treatment are crucial for the outcome of central nervous system (CNS) infections. In this study, we developed a multiplex PCR-Luminex assay simultaneous detection five major pathogens, including Mycobacterium tuberculosis, Cryptococcus neoformans, Streptococcus pneumoniae, herpes simplex virus types 1 2, which frequently cause CNS Through hybridization reaction between PCR-amplified targets oligonucleotide "anti-TAG" sequences, found that could detect as low 10¹-10²...
Visceral artery aneurysm (VAA) is a rare and potentially life-threatening condition, defined as true aneurysms pseudoaneurysms of splanchnic circulation renal artery. This study reports our experience in the diagnosis endovascular treatment visceral (VAAs) over 10-year period. Between 2008 2018, total 24 VAAs 21 patients were diagnosed by clinical symptoms combination imaging techniques, such Doppler ultrasound, computed tomography angiogram, catheter angiogram. All underwent to exclude...