A5030023364- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cutaneous lymphoproliferative disorders research
- Radiopharmaceutical Chemistry and Applications
- Cancer Mechanisms and Therapy
- Bone health and treatments
- Circular RNAs in diseases
- RNA modifications and cancer
- Cancer Diagnosis and Treatment
Huizhou Central People's Hospital
2015-2025
Non-small cell lung cancer (NSCLC) is a widespread and gefitinib primary therapy for NSCLC patients. Nevertheless, the underlying mechanisms progression of acquired drug resistance have not been clarified. The aim this study was to investigate role circular RNA (circ_0001786) in gefitinib-resistant NSCLC.
Abstract This study aimed to assess the efficacy and safety of three dosing regimens JMT103 in patients with bone metastases from solid tumors. Eligible were randomly assigned receive subcutaneously, 120 mg every 4 weeks (Cohort 1), 8 2), or 180 3) for up 49 weeks. The primary endpoint was change baseline Week 13 creatinine‐adjusted urinary N‐telopeptide (uNTx/Cr). Two hundred ninety‐five randomized, 293 received at least one dose JMT103, whom 96 Cohort 1, 97 2, 100 3. median (interquartile...
MicroRNAs (miRNAs) are a group of small non‑coding RNA molecules, which serve an important function in the development multidrug resistance cancer through post‑transcriptional regulation gene expression and silencing. In present study, functional effects miR‑197 were analyzed chemo‑resistant gastric cells. Low levels observed fluorouracil (5‑FU)‑resistant cell line SGC7901/5‑FU when compared with those parental SGC7901. Overexpression cells was identified to partially restore 5‑FU...
Abstract Long intergenic noncoding ribonucleic acid (lncRNA) 460 is reportedly associated with carcinogenesis and progression in various types of cancer. However, the mechanisms underlying its action cutaneous squamous cell carcinoma (CSCC) remain unclear. LINC00460 mRNA expression was analysed using data from Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases. Cell growth, migration, invasion were evaluated Counting Kit-8 (CCK-8), 5-ethynyl-2′-deoxyuridine (EdU), transwell...