A5100638438- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- Cancer Treatment and Pharmacology
- Anesthesia and Pain Management
- Pain Mechanisms and Treatments
- Anesthesia and Sedative Agents
- Breast Cancer Treatment Studies
- Atrial Fibrillation Management and Outcomes
- Uterine Myomas and Treatments
- Venous Thromboembolism Diagnosis and Management
- Cardiac Arrhythmias and Treatments
- Respiratory Support and Mechanisms
- Endometriosis Research and Treatment
- Endometrial and Cervical Cancer Treatments
- Hemodynamic Monitoring and Therapy
- Healthcare and Venom Research
- Treatment of Major Depression
- Nausea and vomiting management
- Heart Failure Treatment and Management
- Mechanical Circulatory Support Devices
- Cancer Cells and Metastasis
- Mesenchymal stem cell research
- Cancer Immunotherapy and Biomarkers
- Cardiac, Anesthesia and Surgical Outcomes
- Peptidase Inhibition and Analysis
Oregon Health & Science University
2015-2025
Peking University
2018-2025
Peking University Cancer Hospital
2018-2025
First Affiliated Hospital of Xi'an Jiaotong University
2023-2024
Hubei University of Medicine
2012-2024
First Hospital of Jilin University
2024
Jilin University
2024
Weatherford College
2024
Xi'an Jiaotong University
2024
Stanford Health Care
2023
Abstract Mesenchymal stem/stromal cells (MSCs) derived from placental tissue show great therapeutic potential and have been used in medical treatment, but the similarity differences between MSCs various parts of placenta remain unclear. In this study, we compared different perinatal tissues, including umbilical cord (UC), amniotic membrane (AM), chorionic plate (CP) decidua parietalis (DP). Using human leukocyte antigen (HLA) typing karyotype analysis, found that first three cell types were...
ABSTRACT How viral and host factors contribute to the severe pathogenicity of H5N1 subtype avian influenza virus infection in humans is poorly understood. We identified three clusters differentially expressed innate immune response genes lungs from (A/Vietnam/1203/04) virus-infected ferrets by oligonucleotide microarray analysis. Interferon were more strongly H5N1-infected ferret than infected with less pathogenic H3N2 subtype. In particular, robust CXCL10 gene expression led us test role...
To compare the effectiveness and safety of remimazolam tosylate propofol for hysteroscopy.From November 2020 to June 2021, a total 90 patients who underwent hysteroscopy were prospectively enrolled in this study. The randomly assigned three groups: group (group A), low-dose B), high-dose C), with 30 cases each group. All received intravenous sufentanil 0.1ug/kg analgesic preconditioning. Patients A given 2 mg/kg intravenously, maintained at rate 5 mg/kg/h. groups B C 0.25 mg/kg. Group was...
The aim of this study was to identify pigments present in the red dragon fruit (Hylocereus polyrhizus) and further investigate antioxidant properties fruit. Pigment identified using High Performance Liquid Chromatography (HPLC) results confirmed presence betanin sample at a retention time 11.5 min which corresponded standard used. In determination, there were 86.10 mg total polyphenolic compound 0.50 g dried extract polyphenol assay expresses gallic acid as equivalent. reducing power...
Passiflora foetida L. (stinking passion flower) is an exotic medicinal vine. The antibacterial properties of leaf and fruit (ethanol acetone) extracts were screened against four human pathogenic bacteria i.e. Pseudomonas putida, Vibrio cholerae, Shigella flexneri Streptococcus pyogenes by well-in agar method. results showed the extract having remarkable activity all bacterial pathogens compared to fruits. This study supports, traditional medicines (herbal extracts) cure many diseases like...
Background Brucellosis is a zoonotic disease that threatens public health and creates an economic burden. Unfortunately, it often overlooked in developing countries, with misdiagnosis causing negative impacts on those low income. Although the symptoms of brucellosis are commonly reported as fever fatigue, rare pulmonary, psychiatric involvements should also be considered. We present first patient China multiple pulmonary nodules depression. Furthermore, this report highlights importance...
Calcitriol has been demonstrated to provide neuroprotection against ischemia/reperfusion (I/R) injury. However, the exact mechanism of this protection remains unknown. In present study, neuroprotective effect calcitriol was investigated in rats exposed cerebral I/R injury induced by middle artery occlusion (MCAO). addition, involvement NR3A, extracellular signal‑regulated kinase 1/2 (ERK1/2), and phosphorylated cAMP/Ca2+‑response element binding protein (p‑CREB) protective action determined...
Abstract This study aimed to assess the efficacy and safety of three dosing regimens JMT103 in patients with bone metastases from solid tumors. Eligible were randomly assigned receive subcutaneously, 120 mg every 4 weeks (Cohort 1), 8 2), or 180 3) for up 49 weeks. The primary endpoint was change baseline Week 13 creatinine‐adjusted urinary N‐telopeptide (uNTx/Cr). Two hundred ninety‐five randomized, 293 received at least one dose JMT103, whom 96 Cohort 1, 97 2, 100 3. median (interquartile...
Fluzoparib (SHR3162) is a novel, potent poly(ADP-ribose) polymerases (PARP)1, 2 inhibitor that showed anti-tumor activity in xenograft models. We conducted phase I, first-in-human, dose-escalation and expansion (D-Esc D-Ex) trial patients with advanced solid cancer.This was 3+3 I D-Esc 3-level D-Ex at 5 hospitals China. Eligible for had tumors refractory to standard therapies, enrolled ovarian cancer (OC). administered orally once or twice daily (bid) 11 dose levels from 10 400 mg/d....
The mortality risk related to anaesthesia in China remains poorly characterized. objective of this study was evaluate the anaesthesia-related terms its incidence, changes, causes and preventability Hubei, China, between 2017 2021 using a series annual surveys.We prospectively collected information on patient, surgical, anaesthesia, hospital characteristics for 9,391,669 procedures performed 10 cities within Hubei Province, China. Anaesthesia-related death defined as that deemed be entirely...
Background: The presence of a high neutrophil-to-lymphocyte ratio (NLR) has been associated with increased mortality in several malignancies. And the majority studies on breast cancer (BC) analyzed patients early-stage. Fewer focused metastatic BC (MBC). De novo stage IV no prior treatment is more suitable for analyzing prognostic factors. Herein, we examined value baseline NLR de patients.
We aimed to clarify tumor features and prognosis of pregnancy-associated breast cancer (PABC) among Chinese women.PABC was defined as diagnosed during pregnancy or within a year after delivery. Patients with PABC were selected from cases women ≤45 years treated at our institution between December 2012 2017, one non-PABC control matched for stage, age, diagnosis each case.Forty-one identified (22 19 1 delivery). There significantly more progesterone receptor (PR)- triple-negative tumors in...
Abstract Purpose To determine the impact of a pharmacist-driven methicillin-resistant Staphylococcus aureus (MRSA) nasal polymerase chain reaction (PCR) screen on vancomycin duration in critically ill patients with suspected pneumonia. Methods This was retrospective, quasi-experimental study at 613-bed academic medical center 67 intensive care beds. Adult admitted to unit (ICU) between 2017 and 2019 for 24 hours or longer empirically started intravenous pneumonia were included. The primary...
Describe the efficacy and safety of guanfacine for dexmedetomidine weaning in critically ill patients.Retrospective descriptive analysis.Six hundred thirteen-bed academic medical center from October 2020 to 2021.All Adult patients on IV who received at least one dose sedation or agitation were included.Enteral guanfacine.The primary outcome was discontinuation therapy within 48 hours after initiation. Secondary outcomes assessed included adjunctive medication use, rate reinitiation,...
Abstract Purpose To evaluate the efficacy and safety of pegylated liposomal doxorubicin (PLD) in patients with human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (MBC) heavily pretreated anthracycline taxanes. Methods In this single-arm, phase II study, HER2-negative MBC previously treated taxanes as second- to fifth chemotherapy received PLD (Duomeisu ® , generic hydrochloride liposome) 40 mg/m every 4 weeks until disease progression, unacceptable toxicity, or...
Abstract Objective: Triple-negative breast cancer (TNBC) is a heterogeneous disease with poor prognosis. Circulating tumor cells (CTCs) are promising predictor for prognoses but their reliability regarding progression-free survival (PFS) controversial. We aim to verify predictive value in TNBC. Methods: In present prospective cohort study, we used the Pep@MNPs method enumerate CTCs baseline blood samples from 75 patients TNBC (taken at inclusion this study) and analyzed correlations between...
OBJECTIVES: Tracheal intubation (TI) is a common procedure in critical care, often performed with Macintosh curved blade used for direct laryngoscopy (DL). Minimal evidence informs the choice between sizes during TI. We hypothesized that 4 would have higher first-attempt success than 3 DL. DESIGN: Retrospective analysis using propensity score and inverse probability weighting of data from six prior multicenter randomized trials. SETTING AND PARTICIPANTS: Adult patients who underwent...