A5088235442- Bacterial Identification and Susceptibility Testing
- Antibiotics Pharmacokinetics and Efficacy
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Use and Resistance
- Neonatal Respiratory Health Research
- Pneumonia and Respiratory Infections
- Neutropenia and Cancer Infections
- Clostridium difficile and Clostridium perfringens research
- Colorectal Cancer Surgical Treatments
- Mycobacterium research and diagnosis
- Complementary and Alternative Medicine Studies
- Anorectal Disease Treatments and Outcomes
- Surgical site infection prevention
- Neonatal and fetal brain pathology
- Nosocomial Infections in ICU
- Kawasaki Disease and Coronary Complications
- Respiratory viral infections research
- Congenital Diaphragmatic Hernia Studies
- Bacterial biofilms and quorum sensing
- Antibiotic Resistance in Bacteria
- Chemotherapy-related skin toxicity
- Healthcare Decision-Making and Restraints
- Liver Disease and Transplantation
- Coronary Artery Anomalies
- Neonatal and Maternal Infections
Yibin University
2024
China Medical University
2024
Stanford University
2013-2023
Stanford Health Care
2013-2023
National Patient Safety Foundation
2020
University of Missouri–Kansas City
1990
Children's Mercy Hospital
1990
Truman Medical Center
1990
Study Objective The optimal pharmacodynamic parameter for the prediction of efficacy vancomycin is area under concentration–time curve (AUC), and current published data indicate that dosing based on trough concentrations an inaccurate substitute. In this study, our objective was to compare achievement therapeutic target attainment after switching from a trough‐based AUC‐based strategy as part institution's vancomycin‐per‐pharmacy protocol. Design Prospective observational quality assurance...
Abstract Background Using published data, we sought to compare outcomes in patients transitioned either oral fluoroquinolones (FQs) or trimethoprim-sulfamethoxazole (TMP-SMX) vs ß-lactams (BLs) after an initial intravenous (IV) course for gram-negative rod (GNR) bacteremia. Methods We conducted a systematic review of PubMed and EMBASE IDWeek abstracts. included studies that reported all-cause mortality and/or infection recurrence FQ/TMP-SMX BLs. Results Eight retrospective met inclusion...
Study Objective To evaluate the pharmacokinetics of gentamicin in neonates with hypoxic ischemic encephalopathy ( HIE ) receiving hypothermia and to identify an empiric dosing strategy this population that optimizes achievement target peak trough concentrations. Design Population pharmacokinetic study using retrospective medical record data. Setting Tertiary neonatal intensive care unit. Patients A total 29 full‐term diagnosed treated who received underwent therapeutic drug monitoring...
We compared antibiotic prescribing before and during the -coronavirus disease 2019 (COVID-19) pandemic at 2 academic urgent care clinics found a sustained decrease in driven by respiratory encounters despite transitioning to telemedicine. Antibiotics were rarely prescribed for COVID-19 or symptoms. revealed opportunities outpatient stewardship programs.
One institution's experience with use of peripheral i.v. (PIV) catheters for prolonged infusions 3% sodium chloride injection at rates up to 100 mL/hr is described. A prospective, observational, 13-month quality assurance project was conducted an academic medical center evaluate frequencies patient and catheter phlebitis among adult inpatients who received both infusion a period ≥4 hours through dedicated PIV routine-care solutions (RCSs) separate during the same hospital stay. Sixty...
Clinical justification for rapid antimicrobial susceptibility testing (AST) in Gram-negative rod (GNR) bacteremia is compelling; however, evidence supporting its value sparse. We investigated the impact of AST on clinical and stewardship outcomes real-world practice. performed a before-and-after quasi-experimental study from February 2018 to July 2019 at tertiary hospital 24-h/day, 7-day/week implementation direct Vitek 2 method positive blood culture broth GNR with electronic...
Abstract Purpose To determine the impact of a pharmacist-driven methicillin-resistant Staphylococcus aureus (MRSA) nasal polymerase chain reaction (PCR) screen on vancomycin duration in critically ill patients with suspected pneumonia. Methods This was retrospective, quasi-experimental study at 613-bed academic medical center 67 intensive care beds. Adult admitted to unit (ICU) between 2017 and 2019 for 24 hours or longer empirically started intravenous pneumonia were included. The primary...
Introduction Camphora longepaniculata , a crucial commercial crop and fundamental component of traditional Chinese medicine, is renowned for its abundant production volatile terpenoids. However, the lack available genomic information has hindered pertinent research efforts in past. Methods To bridge this gap, present study aimed to use PacBio HiFi, short-read, highthroughput chromosome conformation capture sequencing construct chromosome-level assembly C. genome. Results discussion With...
A pharmacist-driven methicillin-resistant Staphylococcus aureus (MRSA) nasal polymerase chain reaction (PCR)-based testing protocol with a 70% acceptance rate for vancomycin discontinuation within 24 hours of negative results significantly reduced unnecessary use an estimated cost avoidance $40 per course. We found high concordance (141 147, 96%) culture-based versus PCR-based MRSA screening.
To explore the clinical characteristics, related factors, and prognosis of Kawasaki disease (KD) combined with acute febrile cholestasis improve understanding liver complications KD to avoid misdiagnosis missed diagnosis. We retrospectively analyzed demographic, clinical, laboratory data 1803 patients between January 2019 July 2023 in our hospital. Based on presence cholestasis, were divided into cholestatic control groups. Logistic regression analysis was performed for statistically...
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13N-ammonia and 18F-fluorodeoxyglucose positron emission tomography (PET) of the heart were performed on 30 children with a history Kawasaki disease. The results indicated PET abnormalities in 61.1% patients during acute subacute stages 41.2% convalescent stage Two-dimensional echocardiography coronary angiography could not predict myocardial viability perfusion as well PET. Different therapies disease did effectively prevent damage, despite absence arterial abnormalities. who received 400...
Abstract Background Patients with Gram-negative bloodstream infection (GN BSI) commonly transition from intravenous (IV) to oral therapy after clinical improvement. Some reports suggest similar outcomes step down TMP/SMX or BL compared FQ in uncomplicated GN BSI, despite questionable pharmacodynamic target achievement administration of the former. We sought compare Stanford Health Care (SHC) patients BSI who received step-down vs. TMP/SMX. Methods This was a retrospective cohort study...
This case series describes the development of morbilliform drug eruption after breast surgery.