A5103253624- Antimicrobial Resistance in Staphylococcus
- Anesthesia and Sedative Agents
- Bacterial Identification and Susceptibility Testing
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- Antibiotic Use and Resistance
- Antibiotics Pharmacokinetics and Efficacy
- Venous Thromboembolism Diagnosis and Management
- Pneumonia and Respiratory Infections
- Cardiac Health and Mental Health
- Platelet Disorders and Treatments
- Traumatic Brain Injury Research
- Nosocomial Infections in ICU
- Antibiotic Resistance in Bacteria
- Atrial Fibrillation Management and Outcomes
- Neurosurgical Procedures and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Traumatic Brain Injury and Neurovascular Disturbances
- Opioid Use Disorder Treatment
- Case Reports on Hematomas
- Cardiac Arrhythmias and Treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Autoimmune Bullous Skin Diseases
- Healthcare Decision-Making and Restraints
- Mechanical Circulatory Support Devices
Stanford Health Care
2019-2025
University of Toronto
2023-2025
Oregon Health and Science University Hospital
2023
Public Health Ontario
2023
Stanford Medicine
2019
McMaster University
2015-2018
The use of an alteplase (Activase) purge solution to address Impella ventricular assist device “thrombosis” or “purge system occlusion” has been mainly documented with earlier generation devices (CP, 2.5, 5.0). Here, we report the manage 5.5 occlusion in a 31-year-old male admitted cardiac care unit cardiogenic shock and listed for heart transplant. Throughout occlusion, patient demonstrated hemodynamic stability overall pump flow output were preserved. Initially, there was lack response...
Abstract Background Current American Thoracic Society and Infectious Diseases of America community-acquired pneumonia (CAP) guidelines recommend empiric antibiotic therapy against methicillin-resistant Staphylococcus aureus (MRSA) or Pseudomonas aeruginosa (P. aeruginosa) in individuals with major risk factors: (1) MRSA P. growth respiratory cultures within the past year (2) severe CAP prior hospitalization receipt parenteral antibiotics preceding 90 days. The objective this study was to...
Substance use disorders are increasing in incidence yet may be underrecognized the surgical population. Perioperatively, these substances and/or treatments for acutely stopped, risk of withdrawal symptoms and accidents, such as falls. However, there have been no studies evaluating association between substance postoperative falls a broad A retrospective cohort analysis adults (≥18 years) undergoing case mix major elective noncardiac surgeries was conducted using New York State Inpatient...
Describe the efficacy and safety of guanfacine for dexmedetomidine weaning in critically ill patients.Retrospective descriptive analysis.Six hundred thirteen-bed academic medical center from October 2020 to 2021.All Adult patients on IV who received at least one dose sedation or agitation were included.Enteral guanfacine.The primary outcome was discontinuation therapy within 48 hours after initiation. Secondary outcomes assessed included adjunctive medication use, rate reinitiation,...
The role of piperacillin/tazobactam for treatment serious infections due to AmpC-producing organisms remains debatable, particularly in immunocompromised patients.This was a retrospective cohort study patients that investigated the effect definitive with either versus cefepime or carbapenems bacteraemia caused by cefoxitin-non-susceptible Enterobacterales. primary endpoint composite clinical and microbiological failure. A logistic regression model constructed assess impact choice on...
Abstract Purpose To determine the impact of a pharmacist-driven methicillin-resistant Staphylococcus aureus (MRSA) nasal polymerase chain reaction (PCR) screen on vancomycin duration in critically ill patients with suspected pneumonia. Methods This was retrospective, quasi-experimental study at 613-bed academic medical center 67 intensive care beds. Adult admitted to unit (ICU) between 2017 and 2019 for 24 hours or longer empirically started intravenous pneumonia were included. The primary...
A pharmacist-driven methicillin-resistant Staphylococcus aureus (MRSA) nasal polymerase chain reaction (PCR)-based testing protocol with a 70% acceptance rate for vancomycin discontinuation within 24 hours of negative results significantly reduced unnecessary use an estimated cost avoidance $40 per course. We found high concordance (141 147, 96%) culture-based versus PCR-based MRSA screening.
SUMMARY Objective Retrospective audit of IVIG Request Forms in four Ontario tertiary care centres: to determine the case mix new requests, authenticate information provided, and documentation clinical efficacy. Aims To understand contributors increases utilisation whether is being used monitored appropriately. Introduction Intravenous immunoglobulin ( ) use Canada high compared with other developed countries. We performed a retrospective across centres Ontario, one an active surveillance...
Abstract Background Perioperative bridging in atrial fibrillation (AF) is associated with low thromboembolic rates but high bleeding rates. Recent guidance cautions the practice of except risk patients. However, varies widely and little data exist regarding appropriate anticoagulation intensity when using intravenous unfractionated heparin (UFH). Hypothesis To determine if UFH infusion regimens are increased compared to for patients AF. Methods We conducted a single center retrospective...
Objective Post-traumatic seizure (PTS) is a well-known complication of traumatic brain injury (TBI). The objective this study was to identify risk factors associated with breakthrough early PTS in TBI patients receiving phenytoin prophylaxis. Methods This single-centered retrospective including adult admitted the intensive care unit (ICU), had TBI, and started on for prophylaxis within 24 h admission. primary outcome incidence PTS, defined as confirmed continuous electroencephalogram 7 days...
Diep, Calvin; Nguyen, Cherwyn; Kuo, Jamie; Lorenzo, Javier; Ran, Ran Author Information
Objective: Describe the incidence and natural progression of psychological distress after major surgery. Summary Background: The recovery process following surgery imposes physical mental burdens that put patients at risk distress. Understanding course is critical to supporting timely tailored management high-risk individuals. Methods: We conducted a secondary analysis Measurement Exercise Tolerance before Surgery (METS) multicentre cohort study (Canada, Australia, New Zealand, UK). METS...
Abstract Background Post traumatic seizure (PTS) is a well-known complication of brain injury (TBI). The objective this study to identify risk factors associated with breakthrough early PTS in TBI patients receiving phenytoin prophylaxis. Methods This was single centered retrospective including adult admitted the intensive care unit, had TBI, and started on for prophylaxis within 24 hours admission. primary outcome incidence PTS, defined as confirmed continuous electroencephalogram 7 days...
Abstract Background Limited published data supports the de-escalation of empiric anti-methicillin resistant Staphylococcus aureus (MRSA) antibiotics for suspected pneumonia upon negative nasal MRSA screening. Besides limited sample sizes, special populations, such as those who are immunocompromised and/or critically ill, have been underrepresented in these reports. We describe real-world efficacy and safety a pharmacist-driven PCR testing protocol implemented at Stanford Health Care May 2018...
Abstract Background A recent guidance suggested “caution if prescribing piperacillin-tazobactam for serious infections caused by organisms at high risk of significant AmpC production” and that the preferred antibiotic choice should be either cefepime or a carbapenem, despite an admitted lack definitive evidence. Examination this question in immunocompromised patients may provide such Methods This was retrospective, single-center study conducted from January 2016 to December 2021. We included...
Introduction: Augmented renal clearance (ARC) has been associated with sub-optimal antibiotic concentrations. Administering vancomycin as a continuous infusion may be strategy to achieve therapeutic levels faster less monitoring. The purpose of this study was compare the safety and efficacy (CIV) versus intermittent (IIV) in critically ill patients ARC. Methods: This single-center, retrospective adult admitted ICU at Stanford Health Care. Patients were included if they received intravenous...