A5101947987- Inflammatory Bowel Disease
- Eosinophilic Disorders and Syndromes
- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- RNA modifications and cancer
- Immune cells in cancer
- Genetic factors in colorectal cancer
- Pediatric Hepatobiliary Diseases and Treatments
- IL-33, ST2, and ILC Pathways
- Kawasaki Disease and Coronary Complications
- Curcumin's Biomedical Applications
- Vascular Malformations and Hemangiomas
- Lymphatic Disorders and Treatments
- Ferroptosis and cancer prognosis
- Phagocytosis and Immune Regulation
- Cancer Treatment and Pharmacology
- Advancements in Transdermal Drug Delivery
- Thermal Regulation in Medicine
- Allergic Rhinitis and Sensitization
- Brain Metastases and Treatment
- Digestive system and related health
- Liver Diseases and Immunity
- MicroRNA in disease regulation
- Ear and Head Tumors
- Coronary Artery Anomalies
China Medical University
2011-2024
Chengdu University of Traditional Chinese Medicine
2024
Ningbo University
2021-2024
Shandong University
2015-2024
Handan College
2024
Xiangya Hospital Central South University
2022
Central South University
2022
Huazhong University of Science and Technology
2021
Qingdao University
2021
Qingdao Women and Children's Hospital
2021
Abstract The growing prevalence of inflammatory bowel disease (IBD) has encouraged research efforts, which have contributed to gradual improvements in our understanding IBD diagnosis and therapeutic approaches. pathogenesis not been fully elucidated; however, the combined actions environmental, genetic, immune factors, microbial organisms are believed cause IBD. In innate system, macrophages play important roles maintaining intestinal health development Macrophages can be polarized from M0...
Dabigatran, an anticoagulant, may increase the risk of bleeding in patients with dysfibrinogenemia because coagulation irregularities, especially at high doses. Cranial Magnetic Resonance Imaging (MRI) and Venography (MRV) were used diagnosis venous sinus thromboembolism a 42-year-old woman hereditary dysfibrinogenemia, as documented our case report. MRI suggested thrombosis sinuses, which was confirmed by MRV thromboses superior sagittal, straight, left transverse, sigmoid sinuses. Instead...
Abstract The pathogenesis of inflammatory bowel disease (IBD) remains unclear, and it is currently believed that an imbalance in regulatory T (Treg) cells/T helper 17 cells (Th17 cells) related to the occurrence development IBD. Recently, JAK2 inhibitor AG490 has been used animal models such as rheumatoid arthritis bronchial asthma shown exert immunoregulatory functions improve disorder Treg/Th17 cell balance. This study aimed evaluate effect on intestinal process IBD rat model. A dextran...
MicroRNAs (miRs) have been found to play a fundamental role in the pathology and progression of hemangioma. Of note, miR‑203a‑3p prevents hemangioma via inactivation PI3K/AKT pathway. Bleomycin pingyangmycin are drugs used sclerotherapy, but certain patients experience drug resistance, leading poor clinical outcomes. The present study aimed explore impact on bleomycin sensitivity hemangioma, as well involvement or negative control mimics were transfected into human endothelial cells, which...
Abstract Objective This retrospective longitudinal cohort study aimed to explore the best therapeutic regimen and treatment duration of cough variant asthma (CVA) in children. Methods A total 314 children with CVA were divided into receive inhaled corticosteroids (ICS) combined long‐acting beta2‐agonist (LABA) group, ICS leukotriene receptor antagonists (LTRA) monotherapy group LTRA group. All clinical data statistically analyzed. Logistic regression model was used compare advantages...
To explore the clinical characteristics, related factors, and prognosis of Kawasaki disease (KD) combined with acute febrile cholestasis improve understanding liver complications KD to avoid misdiagnosis missed diagnosis. We retrospectively analyzed demographic, clinical, laboratory data 1803 patients between January 2019 July 2023 in our hospital. Based on presence cholestasis, were divided into cholestatic control groups. Logistic regression analysis was performed for statistically...
Mice are the most frequently used animals in pharmacokinetic studies; however, collecting series of blood samples from mice is difficult because their small sizes and tiny vessels. In addition, due to sample size, it problematic perform high required quantification. Thus, present work aims find an effective strategy for overcoming these challenges using trans-resveratrol as a tool drug. Based on idea joint technology, capillary microsampling (CMS) was chosen collection after delivery (150...
Clinically non‑functioning pituitary adenoma (NFPA) represents approximately one third of all adenomas. Tumor regrowth is an important feature NFPA; however, the effective methods with which to predict this are limited. The present study analyzed expression protein‑coding genes and long non‑coding RNA in 66 patients NFPA. Cox regression analysis was performed identify associated or progression‑free survival (PFS). Kaplan‑Meier, random forest receiver operating characteristic curve (ROC)...
The aim of this study was to investigate the clinical effect AO miniplate screw internal fixation and Kirschner wire (KW) in treatment metacarpal fractures.We retrospectively analyzed data 590 fracture patients admitted our hospital from March 2016 2019. Among them, 290 were treated with KWs; 300 microplate fixation. clinical, radiological results, time surgery, complications observed compared between 2 groups.The imaging characteristics preoperative types groups similar comparable (P >...
Objective To study the effect of acupuncture on ratio CD4+ CD25+ regulatory T cells and expression transcription factor Foxp3 in patients with septic shock. Methods Sixty-four shock were randomly divided into two groups by using random number table method.Acupuncture group(34 cases) was treated both western medicine acupuncture, control group(30 medicine.The period treatment 7 days.After treatment, peripheral blood determined flow cytometry.And mRNA detected quantitative real time...
Ethosomes, as a new vector for transdermal drug delivery, could obviously improve the penetration of drugs. In this study, we prepared testosterone undecanoate ethosomes, with TU ethosomes basic remedy, to determine its appearance, particle size, entrapment efficiency (EE) and membrane fluidity. Meanwhile, test was conducted in mice, order permeability characteristics compare behaviors liposomes their ethanol solutions.
Primary intestinal lymphangiectasia is a rare disease, which characterized by the obstruction of lymphatic return, dilated lymphatics and distorted structure villi. Lymph fluid leaks into small bowel lumen as result elevated pressure lymphatics, leads to malabsorption loss proteins. The causes pathogenesis PIL are not clear, hut abnormal immunologic mechanism has got people's attention. Recently, endoscopic technique been improved, diagnosis rate increased obviously. Antisecosis basic...
The early diagnosis of cholangiocarcinoma is difficult, and the prognosis poor. molecular mechanisms underlying development, growth metastatic spread biliary tract cancers are still unclear. increase in worldwide incidence mortality justifies impellent need to clarify intracellular triggering malignant transformation epithelium malignancies. A more complete characterization pathology bile duct could lead identification valid targets for therapy these devastating This review describes...
Treatment strategy of cough variant asthma in children–A retrospective longitudinal cohort study ChinaTo the Editor,Cough (CVA) is most common cause chronic cough, accounting for 41.95% causes among Chinese children, which greatly affects their learning, sleep, and quality life[1,2]. About 40%–50% CVA patients may eventually develop wheezing symptoms progress to typical if no appropriate timely treatment given [3]. However, plan duration children with remain unclear. To this end, we...
With the development of medicine, change disease spectrum and improvement diagnosis treatment, some hereditary diseases are increasingly appearing in pediatric diseases. We retrospectively analyzed clinical data genetic results 111 children who met inclusion criteria visited research center from January 2015 to December 2019, improve awareness gene detection for early accurate metabolic The average age participants underwent testing was 2.45 ± 2.80 years (male:female 1.58:1). manifestations...