A5103041815- Parkinson's Disease Mechanisms and Treatments
- Autophagy in Disease and Therapy
- Plant Stress Responses and Tolerance
- Plant Molecular Biology Research
- Endoplasmic Reticulum Stress and Disease
- Alzheimer's disease research and treatments
- Plant Gene Expression Analysis
- Plant tissue culture and regeneration
- Esophageal Cancer Research and Treatment
- Cytomegalovirus and herpesvirus research
- Gastric Cancer Management and Outcomes
- Ginkgo biloba and Cashew Applications
- Insect-Plant Interactions and Control
- GABA and Rice Research
- Traditional Chinese Medicine Analysis
- Tuberculosis Research and Epidemiology
- Plant-based Medicinal Research
- Nerve injury and regeneration
- Indoor Air Quality and Microbial Exposure
- Neurological Disease Mechanisms and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Planarian Biology and Electrostimulation
- Nuclear Receptors and Signaling
- Transgenic Plants and Applications
- Gastrointestinal Bleeding Diagnosis and Treatment
Nanjing Drum Tower Hospital
2024
Nanjing Medical University
2024
Nanjing University
2024
Shanghai Jiao Tong University
2006-2024
Shanghai First People's Hospital
2024
University of Macau
2018-2023
Binzhou University
2022-2023
Binzhou Medical University
2022-2023
Hunan Agricultural University
2008-2022
First Affiliated Hospital of Nanchang University
2022
<sup>18</sup>F-labeled BMS747158 is a novel myocardial perfusion imaging tracer that targets mitochondrial complex 1. The objectives of this phase I study were to evaluate radiation dosimetry, biodistribution, human safety, tolerability, and early elimination <sup>18</sup>F activity in urine after injection single dose the at rest healthy subjects. <b>Methods:</b> Thirteen subjects injected with 170–244 MBq (4.6–6.6 mCi) intravenously. Dynamic PET was obtained over heart for 10 min, followed...
The F-box protein CORONATINE INSENSITIVE1 (COI1) plays a central role in jasmonate (JA) signaling and is required for all JA responses Arabidopsis (Arabidopsis thaliana). To dissect signal transduction, we isolated the partially suppressing coi1 (psc1) mutant, which suppressed insensitivity to inhibition of root growth. psc1 mutant restored sensitivity coi1-2 background displayed hypersensitivity wild-type COI1 background. Genetic mapping, sequence analysis, complementation tests revealed...
To investigate whether brassinosteroids (BR) affects cytokinin (CK)-induced anthocyanin biosynthesis, seedlings of the Arabidopsis dwarf4 (dwf4) mutants including partially suppressing coi1 (psc1) and dwf4-102, which are defective in BR brassinosteroid-insensitive 1-4 (bri1-4) mutant signalling were used for analysis CK-induced accumulation expression biosynthetic genes WD-repeat/Myb/bHLH transcription factors. The results show that was remarkably reduced dwf4 bri1-4 mutants, but distinctly...
Rationale: Impairment of autophagy maturation has been implicated in Alzheimer's disease (AD) pathogenesis.However, the mechanism for this impairment not elucidated, and whether enhancing is a viable therapeutic strategy AD verified.Methods: We examined autophagosome process cell mouse models by immunoblotting.To further understand changes brains, we analyzed transcriptome RNA-sequencing measured expression RAB7, CCZ1 MON1A.We performed brain stereotaxic injections AAV into 3xTg WT to...
Parkinson's disease (PD) is the most common neurodegenerative movement disease. It featured by abnormal alpha-synuclein (α-syn) aggregation in dopaminergic neurons substantia nigra. Macroautophagy (autophagy) an evolutionarily conserved cellular process for degradation of contents, including protein aggregates, to maintain homeostasis. Corynoxine B (Cory B), a natural alkaloid isolated from Uncaria rhynchophylla (Miq.) Jacks., has been reported promote clearance α-syn cell models inducing...
Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide and characterized in part by degeneration of dopaminergic neurons substantia nigra pars compacta (SNc). The main pathological hallmark PD intraneuronal accumulation misfolded α-synuclein (α-syn) aggregates. Mutations SNCA gene (encoding α-syn) variations its copy number are associated with some forms familial PD. In present study, T-006, a new tetramethylpyrazine (TMP) derivative recently reported...
Asperuloside (ASP) is an iridoid glycoside that extracted from Eucommia leaves. used in traditional Chinese medicine and has a long history of benefits on health longevity. Here, we investigated the impact ASP obesity-related metabolic disorders show reduces body weight gain, glucose intolerance, insulin resistance effectively mice fed with high-fat diet (HFD). Intestinal dysbiosis closely linked disorders. Our data indicate achieves these homeostasis by reversing HFD-induced gut changing...
The accumulation and aggregation of α-synuclein (α-syn) is the main pathologic event in Parkinson’s disease (PD), dementia with Lewy bodies, multiple system atrophy. α-Syn-seeded fibril formation its induced toxicity occupy a major role PD pathogenesis. Thus, assessing compounds that inhibit this seeding process considered key towards therapeutics synucleinopathies. Using biophysical biochemical techniques seeding-dependent cell viability assays, we screened total nine natural alkaloid...
Idiopathic pulmonary fibrosis (IPF) is a fibrosing interstitial pneumonia of unknown cause. The most typical characteristic IPF gradual weakening elasticity and increase in hardness/rigidity with aging. This study aims to identify novel treatment approach for explore mechanism mechanical stiffness underlying human umbilical cord mesenchymal stem cells (hucMSCs) therapy. Target ability hucMSCs was examined by labeling cell membrane dye Dil. Anti-pulmonary effect therapy reducing evaluated...
Abstract The transcription factor WRKY70 was previously reported to be a common component in salicylic acid (SA) and jasmonate (JA) mediated signal pathways Arabidopsis . Here, we present that the inactivation of gene wrky70‐1 mutant does not alter responses both JA SA, wrky70 mutation is unable restore coi1 responses. However, overexpression reduces such as expression JA‐induced genes JA‐inhibitory root growth, activates SA‐inducible PR1 These data indicate important but indispensable for...
Gluteal muscle contracture (GMC) is a chronic fibrotic disease of gluteal muscles which characterized by excessive deposition collagen in the extracellular matrix. Transforming growth factor (TGF)-βs have been shown to play an important role progression GMC. However, underlying mechanisms are not entirely clear. We sought explore expression TGF-β/Smad pathway proteins and their downstream targets disease.The levels collagens type I/III, TGF-β1, Smad2/3/4/7 PAI-1 (plasminogen activator...
Parkinson's disease (PD) is the second most common neurodegenerative disorder characterized by accumulation of protein aggregates (namely Lewy bodies) in dopaminergic neurons substantia nigra region brain. Alpha-synuclein (α-syn) major component bodies PD patients, and impairment ubiquitin-proteasome system has been linked to its accumulation. In this work, we developed a tetracycline-inducible expression system, with simultaneous induced α-syn-EGFP bright red fluorescent marker (mCherry)...
Nonsteroidal anti-inflammatory drugs (NSAIDs) and aspirin are widely used clinically but increase the risk of gastrointestinal (GI) complications.To examine current prescription NSAIDs comedication to prevent GI complications from within East Asia by means a questionnaire survey.Representative members Committee International Gastrointestinal Consensus Symposium provided physicians in 6 Asian countries.A total 1,568 participated this survey. Most prescribed nonselective NSAIDs,...