A5100401720- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiovascular Function and Risk Factors
- Mitochondrial Function and Pathology
- Cardiovascular Disease and Adiposity
- Cancer, Lipids, and Metabolism
- Neurological Disease Mechanisms and Treatments
- Angiogenesis and VEGF in Cancer
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- Cardiac Imaging and Diagnostics
- Cardiac Ischemia and Reperfusion
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Extracellular vesicles in disease
- Diet and metabolism studies
- Sirtuins and Resveratrol in Medicine
- Inflammasome and immune disorders
- Receptor Mechanisms and Signaling
- Liver Disease and Transplantation
National Clinical Research Center for Digestive Diseases
2022-2025
Capital Medical University
2015-2025
Beijing Friendship Hospital
2021-2025
Gansu Agricultural University
2024-2025
Hebei Medical University
2020-2025
Fourth Hospital of Hebei Medical University
2020-2025
Huazhong Agricultural University
2023-2025
Ludong University
2024-2025
General Hospital of Shenyang Military Region
2017-2025
Xi’an University of Posts and Telecommunications
2025
Glucagon-like peptide1 receptor (GLP-1R) agonists have been found to reduce alcohol drinking in rodents and overweight patients with use disorder (AUD). However, the probability of low semaglutide doses, an agonist higher potency affinity for GLP-1R, attenuate alcohol-related responses underlying neuronal mechanisms is unknown.In intermittent access model, we examined ability decrease intake block relapse-like drinking, as well imaging binding fluorescently marked nucleus accumbens (NAc)...
Abstract Circular RNAs (circRNAs) are increasingly gaining importance and attention due to their diverse potential functions value as diagnostic biomarkers (disease specific). This study aims explore the novel mechanisms by which exosome-contained circRNAs promote tumor development metastasis in TNBC. We identified increased circRNA circPSMA1 TNBC cells, exosomes, serum exosomes samples from patients. The overexpression of promoted cell proliferation, migration, both vitro vivo. Moreover, we...
Background. The incidence of colon adenocarcinoma (COAD) has been increasing over time. Although ferroptosis and long noncoding RNAs (lncRNAs) have extensively reported to participate in the tumorigenesis development COAD, few studies investigated role ferroptosis-related lncRNAs prognosis COAD. Methods. Gene-sequencing clinical data for COAD were obtained from Cancer Genome Atlas database. coexpression network was constructed using known genes. Cox least absolute shrinkage selection...
Surface-enhanced Raman spectroscopy represents a highly efficient detection method, offering significant advantages in the identification and of target analytes food. To ensure that substrate exhibits high sensitivity, it is essential to facilitate formation stable plasmonic "hot spot" regions. In this study, gold nanospheres (Au NSs) were synthesized on capillary substrates via situ growth seed-mediated method. The results demonstrated optimal signal enhancement was achieved when APTES...
To investigate whether palmitic acid can be responsible for the induction of inflammatory processes, HaCaT keratinocytes were treated with at pathophysiologically relevant concentrations. Secretion levels interleukin-6 (IL-6), tumor necrosis factor- α (TNF- α), interleukin-1 β (IL-1 β), NF- κ B nuclear translocation, activation, Stat3 phosphorylation, and peroxisome proliferator-activated receptor alpha (PPAR α) mRNA protein levels, as well cell proliferation ability measured end treatment...
ABSTRACT Sirtuin 1 (Sirt1), a protein deacetylase, is novel target for bone metabolism. To investigate whether overexpression of Sirt1 in mandibular mesenchymal stem cells (M-MSCs) increased alveolar mass vivo, we generated transgenic mice (Sirt1TG), with gene expression driven by the Prx1 gene, which represents lineage. Our results demonstrated that M-MSCs volume 1-month-old, 9-month-old, and 18-month-old Sirt1TG compared age-matched wild-type (WT) mice, ovariectomized WT stimulating M-MSC...
Parkinson's disease (PD) is a neurodegenerative disorder with progressive loss of dopaminergic (DA) neurons. Systemic inflammation shown to initiate and exacerbate DA neuronal degeneration in the substantia nigra. The infiltration transformation immune cells from peripheral tissues are detected around affected brain regions PD patients. Our previous studies demonstrated crucial role that microglial Nod-like receptor protein (NLRP) 3 inflammasome plays pathogenesis PD. Nevertheless, direct...
It has been argued that metabolically healthy obesity (MHO) does not increase cardiovascular disease (CVD) risk. This study examines the association of MHO with carotid intima-media thickness (cIMT), a proxy CVD risk, in children and adolescents.Data were available for 3,497 adolescents aged 6-17 years from five population-based cross-sectional studies Brazil, China, Greece, Italy, Spain. Weight status categories (normal, overweight, obese) defined using BMI cutoffs International Obesity...
Splice-switching antisense oligonucleotides (ASOs), which bind specific RNA-target sequences and modulate pre-mRNA splicing by sterically blocking the binding of factors to pre-mRNA, are a promising therapeutic modality treat range genetic diseases. ASOs typically 15-25 nt long considered be highly towards their intended target sequence, elements that control exon definition and/or splice-site recognition. However, whether or not splice-modulating also induce hybridization-dependent...
We aimed to explore the roles of circular RNAs (circRNAs) in breast cancer (BCa).RNA was extracted from exosomes and BCa cells analyzed using RNA sequencing technique or microarray.Compared with controls, 1147 1195 circRNAs were dysregulated metastatic localized patients, respectively. A total 480 found patients compared these enriched eight pathways. Compared MCF-7 their exosomes, there 5842 1137 MDA-MB-231 respectively, 5 confirmed real-time quantitative PCR.We identified a number patients.
Aim: To study the role of hsa_circ_0072995 in regulating invasion and migration breast cancer cells. Materials & methods: Hsa_circ_0072995 expression was confirmed by quantitative real-time PCR; evaluating cells through transwell assay; predicating circRNA/microRNAs interaction using miRanda RNAhybrid software; identifying relationship between miR-30c-2-3p luciferase activity detecting location Fluorescence situ hybridization assay. Results: significantly upregulated MDA-MB-231 compared with...
To evaluate whether radiomics signature of pericoronary adipose tissue (PCAT) based on coronary computed tomography angiography (CCTA) could improve the prediction future acute syndrome (ACS) within 3 years.We designed a retrospective case-control study that patients with ACS (n = 90) were well matched to no cardiac events 1496) during years follow-up, then which randomly divided into training and test datasets ratio 3:1. A total 107 features extracted from PCAT surrounding lesions 14...
Ferroptosis is associated with the pathology of myocardial ischemia/reperfusion (MI/R) injury following infarction, which a leading cause death worldwide. Although long noncoding RNAs (lncRNAs) are known to regulate gene expression, their roles in MI/R-induced ferroptosis remain unclear. In this study, we explored lncRNA expression profiles rat model MI/R and found that novel lncRNA, lncAABR07025387.1, was highly expressed MI/R-injured tissues hypoxia/reoxygenation (H/R)-challenged cells....
Abstract Background High turnover intention of nursing assistants was detrimental to the sustainability long-term care. Career adaptability is an important determinant in reducing intention, but little research has explored mechanism from perspective psychological capital. The aim this study analyze association between career and examine mediating role capital among mainland China. Methods A cross-sectional online conducted 276 eight homes Nanjing, participants’ adaptability, capital, were...
The nucleus accumbens (NAc) is the most promising target for drug use disorder treatment. Deep brain stimulation (DBS) of NAc effective However, mechanisms by which DBS produces its therapeutic effects remain enigmatic. Here, we define a behavioral cutoff criterion to distinguish depressive-like behaviors and non-depressive-like in mice after morphine withdrawal. We identified basolateral amygdala (BLA) D1 medium spiny neuron (MSN) pathway that controls Furthermore, paraventricular thalamus...
Long noncoding RNAs (lncRNAs) play pivotal roles in multifarious physiological and pathological processes, their aberrant expression may disturb the normal regulatory network of gene to induce diverse human diseases. Herein, we construct a fluorescent light-up biosensor with low background for label-free detection lncRNAs by coupling duplex-specific nuclease (DSN)-assisted target recycling amplification transcription-driven synthesis fluorogenic RNA aptamer-Corns. We design two linear...