Throughout the developing nervous system, neural stem and progenitor cells give rise to diverse classes of neurons glia in a spatially temporally coordinated manner. In ventral spinal cord, much this diversity emerges through morphogen actions Sonic hedgehog (Shh). Interpretation Shh gradient depends on both amount ligand duration exposure, but mechanisms permitting prolonged responses are not well understood. We demonstrate that Notch signaling plays an essential role process, enabling...

Background With the rapid development of technology, artificial intelligence (AI) has been widely used in diagnosis and prognosis prediction a variety diseases, including cardiovascular disease. Facts have proved that AI broad application prospects accurate diagnosis. Objective This study mainly summarizes research on field disease through bibliometric analysis explores possible future hotpots. Methods The articles reviews regarding between 2000 2023 were selected from Web Science Core...

To evaluate whether radiomics signature of pericoronary adipose tissue (PCAT) based on coronary computed tomography angiography (CCTA) could improve the prediction future acute syndrome (ACS) within 3 years.We designed a retrospective case-control study that patients with ACS (n = 90) were well matched to no cardiac events 1496) during years follow-up, then which randomly divided into training and test datasets ratio 3:1. A total 107 features extracted from PCAT surrounding lesions 14...

Objective The objective of this study was to investigate the association between metabolically healthy obese (MHO) phenotype and risk cardiovascular disease (CVD). Methods A total 9393 subjects aged ≥40 years were enrolled in cohort (2011-2015). participants stratified by body mass index category metabolic at baseline, incidence CVD ascertained follow-up. Results MHO accounted for 6.7%. Compared with normal weight (MHNW) group, demonstrated increased events (HR = 1.91; 95% CI, 1.13-3.24). In...

Depressive and anxiety symptoms are common psychiatric disorders among cancer patients. Among the 137 patients with NMIBC (Non-Muscle-Invasive Bladder cancer), 101 who provided answers to Hospital Anxiety Depression Scale (HADS) Brief Illness Perception Questionnaire (B-IPQ) completed 12-month longitudinal study. Hierarchical regression analyses were conducted evaluate interactions between problems illness perceptions (IPs). Patients displayed less positive IPs more negative IPs. have...

Abstract Podocyte injury and loss are critical events in diabetic nephropathy (DN); however, the underlying molecular mechanisms remain unclear. Here, we demonstrate that asparaginyl endopeptidase (AEP) protects against podocyte through modulating dynamics of cytoskeleton. AEP was highly upregulated glomeruli hyperglycemic stimuli treated-podocytes; gene knockout its compound inhibitor treatment accelerated DN streptozotocin-induced mice, whereas specific induction glomerular cells...

Abstract Objectives To evaluate the association between androgen deprivation therapy (ADT) and depression to identify risk factors for depressive symptoms among prostate cancer (PCa) patients who received ADT. Methods We conducted a prospective, longitudinal, controlled study assessed 3 groups of older patients: ADT group (men were presented with maximum block); radical prostatectomy (RP) (PCa control group: men underwent RP without ADT); benign prostatic hyperplasia (BPH) had BPH). All...

Objective: To Explore the relationship between HPV infection and bacterial vaginosis(BV), vulvovaginal candidiasis(VVC), trichomonal vaginitis(TV). Methods: Clinical data from 1 261 gynecologic outpatients who underwent vaginal microecology type detection during June 2015 to December were collected analyzed in First Affiliated Hospital of Xi'an Jiaotong University. Results: In patients, 328 cases infected with HPV, rate was 26.01%(328/1 261); infectious disease infections 219 cases(66.8%,...

Genetic risk factors could cause cutaneous adverse drug reactions (cADRs) in patients after treatment with clarithromycin. This study explored the association of HLA class I genes clarithromycin-cADRs Han Chinese patients. A total 12 clarithromycin-cADR and 34 clarithromycin-tolerant controls were recruited for high-resolution genotyping (HLA-A, HLA-B HLA-C). The population consisted 283 retrieved from MHC database validated comparison. molecular docking analysis HLA-A*02:07 protein...

The first method for the reduction of α-keto substituted acrylate compounds by Hantzsch ester in water under catalysis thiourea has been developed. products were isolated with moderate to high yields (38–95%).

Calcium signalling in platelets through store operated Ca2+ entry (SOCE) or receptor-operated (ROCE) mechanisms is crucial for platelet activation and function. Orai1 proteins have been implicated platelet's SOCE. In this study we evaluated the contribution of to these processes using washed from adult mice both genders with platelet-specific deletion gene (Orai1flox/flox; Pf4-Cre termed as Orai1Plt-KO) since ubiquitous deficiency show early lethality. Platelet aggregation well release were...

Interpreting complex deep networks, notably pre-trained vision-language models (VLMs), is a formidable challenge. Current Class Activation Map (CAM) methods highlight regions revealing the model's decision-making basis but lack clear saliency maps and detailed interpretability. To bridge this gap, we propose DecomCAM, novel decomposition-and-integration method that distills shared patterns from channel activation maps. Utilizing singular value decomposition, DecomCAM decomposes...

Abstract Objectives To evaluate the diagnostic accuracy of liver dual-layer spectral-detector CT (SDCT) derived parameters parenchyma for grading steatosis with reference to magnetic resonance imaging-based proton density fat fraction (MRI-PDFF). Methods Altogether, 320 consecutive subjects who underwent MRI-PDFF and SDCT examinations were recruited prospectively enrolled from four Chinese hospital centers. Participants classified into normal ( n = 152), mild 110), moderate/severe(mod/sev)...

This study aimed at exploring whether illness perceptions may mediate the relationship between depressive symptoms and lower urinary tract (LUTS) among benign prostatic hyperplasia (BPH) patients. The Patient Health Questionnaire (PHQ-9) for depression, International Prostate Symptom Score (IPSS) severity of LUTS brief Illness Perception (B-IPQ) (IPs) were used 157 BPH patients with LUTS. Pearson's correlation test hierarchical regression analyses to assess correlations LUTS, IPs. Our found...

Hepatic steatosis is closely related to the occurrence and development of coronary plaques. Spectral detector computed tomography (SDCT) can provide more precise multiparameter quantitative parameters for hepatic steatosis. Hence, purpose this cross-sectional study was explore effect liver metrics measured using SDCT on extent severity

This study aimed to determine the effects of Tilburg Frailty Indicator (TFI) and frailty phenotype (FP) in senile inpatients with provide a reference for clinical evaluation debilitating elderly patients. The effect silver nanoparticle (AgNP)-silver needle acupuncture was also evaluated. Overall, 48 an average age 69.5±6.2 years were included study. results two weakness assessment methods screening same population compared, correlation or consistency between analyzed. A AgNPsilver used...

Previous studies have indicated a negative correlation between GRK2 expression and pain development transmission. Here, we investigated whether G-protein-coupled receptor kinase 2 (GRK2) was involved in regulating diabetic mechanical hyperalgesia (DMH).The adeno-associated viral vectors containing the gene (AAV-GRK2) were used to up-regulate protein expression. The of exchange directly activated by cyclic adenosine monophosphate 1 (Epac1) dorsal root ganglion (DRG) lumbar 4-6 detected via...

Objective To investigate the effects of obesity on blood pressure variation and plasma levels nitric oxide (NO) endothelin (ET) in elderly hypertensive patients. Methods A total 175 patients with hypertension were screened for this study. Based body mass index, they categorized into three groups normal weight (n=69), overweight (n=56) (n=50). 24-hour dynamic pressure, NO ET monitored. Results No significant differences 24 h systolic daytime nighttime hours diastolic (24 h-DBP)...

Objective To investigate the difference between electronic sphygmomanometer and mercury in blood pressure (BP) measurement both sitting supine position to instruct clinicians nurses measure accurately with sphygmomanometer.Methods Systolic diastolic of 142 subjects aged 19 ～ 71 ( mean 48.7 ± 9.1 ) years were measured synchronously respectively by two trained bare upper arms position. Blood values sphygmomanometers same arm compared a self -control manner. Results There was no significant...