A5100364925- Ferroptosis and cancer prognosis
- Bladder and Urothelial Cancer Treatments
- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- Renal cell carcinoma treatment
- RNA modifications and cancer
- Esophageal Cancer Research and Treatment
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Prostate Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Treatments and Mutations
- Cancer, Lipids, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Prostate Cancer Treatment and Research
- Urological Disorders and Treatments
- Sexual function and dysfunction studies
- Urinary and Genital Oncology Studies
- Peptidase Inhibition and Analysis
- Liver Disease Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Metastasis and carcinoma case studies
- Urologic and reproductive health conditions
- Nanoplatforms for cancer theranostics
Chinese PLA General Hospital
2024-2025
Shanghai Jiao Tong University
2015-2025
Shanghai First People's Hospital
2015-2025
Jiangsu Province Hospital
2012-2025
Nanjing Medical University
2013-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2025
Institute of Hematology & Blood Diseases Hospital
2021-2025
Beijing Proteome Research Center
2021-2025
Affiliated Hospital of Nantong University
2019-2025
Nantong University
2019-2025
The diffuse-type gastric cancer (DGC) is a subtype of with the worst prognosis and few treatment options. Here we present dataset from 84 DGC patients, composed proteome 11,340 gene products mutation information 274 driver genes covering paired tumor nearby tissue. can be classified into three subtypes (PX1-3) based on altered alone. PX1 PX2 exhibit dysregulation in cell cycle features an additional EMT process; PX3 enriched immune response proteins, has survival, insensitive to...
Adaptive metabolic responses and innate metabolites hold promising therapeutic potential for stroke, while targeted interventions require a thorough understanding of underlying mechanisms. Adiposity is noted modifiable risk factor recent research suggests that it benefits neurological rehabilitation. During the early phase experimental lipidomic results showed fat depots underwent pronounced lipolysis released fatty acids (FAs) feed into consequent hepatic FA oxidation ketogenesis. Systemic...
To evaluate the validity of CHAC1 for predicting prognosis kidney renal clear cell carcinoma (KIRC) and to explore its therapeutic potential KIRC, we conducted several bioinformatic analyses using sequencing data clinical information derived from online databases. We found is down-regulated in KIRC samples when compared with normal but up-regulated relatively higher malignancy later stages. Univariate cox analysis multivariate regression were results revealed an independent risk factor poor...
Abstract Drug repositioning, the strategy of redirecting existing drugs to new therapeutic purposes, is pivotal in accelerating drug discovery. While many studies have engaged modeling complex drug–disease associations, they often overlook relevance between different node embeddings. Consequently, we propose a novel weighted local information augmented graph neural network model, termed DRAGNN, for repositioning. Specifically, DRAGNN firstly incorporates attention mechanism dynamically...
Abstract Diffuse-type gastric cancer (DGC) and intestinal-type (IGC) are the major histological types of (GC). The molecular mechanism underlying DGC IGC differences poorly understood. In this research, we carry out multilevel proteomic analyses, including proteome, phospho-proteome, transcription factor (TF) activity profiles, 196 cases covering in Chinese patients. Integrative proteogenomic analysis reveals ARIDIA mutation associated with opposite prognostic effects between IGC, via...
Abstract Introduction Subjective chronic tinnitus is a common medical syndrome with high frequency of cognitive impairment; however, the characteristics impairment in are poorly understood. Investigating scope across severity spectrum patients may shed light on issue. Methods A consecutive series 207 subjective were classified into mild group ( n = 95) and severe 112) by THI score (the cutoff scores 37/38). These assessed using Cognitive Abilities Screening Instrument (CASI) P300...
Improving tumor immunogenicity is critical for increasing the responsiveness of triple-negative breast cancer (TNBC) to anti-PD-(L)1 treatment. Here, we verified that chidamide (CHI), an epigenetic modulator, could elicit immunogenic cell death within TNBC enhance and antitumor immune response. Additionally, CHI increased expression level PD-L1, MHC I, II on cells, which contributed T-cell recognition PD-1/PD-L1 blockade therapy The synergistic efficacy PD-L1 was further explored through...
Abstract Background Stromal components of the tumor microenvironment contribute to bladder cancer progression, and Cancer-Associated Fibroblasts (CAFs) were reported play an important role. Accumulating pieces evidence indicate that CAFs participate in crosstalk with cells have a complex interaction network immune components. Further studies on role searching for possible specific markers are deeper understanding progression immunomodulation. Methods In present study, we examined abundance...
Smart nanorobots have emerged as novel drug delivery platforms in nanomedicine, potentially improving anti-cancer efficacy and reducing side effects. In this study, an intelligent tumor microenvironment-responsive nanorobot is developed that effectively delivers CpG payloads to Toll-like receptor 9 (TLR9)-positive tumors induce autophagy-mediated cell death for immunotherapy. The are fabricated by co-self-assembly of two amphiphilic triblock polymer peptides: one containing the matrix...
Abstract The Fennec Fox algorithm (FFA) is a new meta-heuristic that primarily inspired by the fox's ability to dig and escape from wild predators. Compared with other classical algorithms, FFA shows strong competitiveness. “No free lunch” theorem an has different effects in face of problems, such as: when solving high-dimensional or more complex applications, there are challenges as easily falling into local optimal slow convergence speed. To solve this problem FFA, paper, improved Fenna...
Genetic variation may influence chemotherapy response and overall survival in cancer patients.We conducted a genome-wide scan 535 advanced-stage non-small cell lung (NSCLC) patients from two independent cohorts (307 Nanjing 228 Beijing). A replication was carried out on an cohort of 340 Southeastern China followed by second validation 409 the Massachusetts General Hospital (Boston, MA).Consistent associations with NSCLC were identified for five single-nucleotide polymorphisms (SNP) Chinese...
Hepatocellular carcinoma (HCC) is serious condition associated with a high morbidity and mortality.Therefore an urgent need to develop novel noninvasive techniques for early diagnosis, particularly patients AFP-negative [AFP(-)] HCC.In this study, iTRAQ-MALDI-MS/MS was used identify differentially expressed proteins in AFP(-) HBV-related HCC compared non-cancerous hepatitis B virus (HBV) healthy controls subjects.Serum obtained from 18 HCC, matched HBV without control subjects.High abundance...
The tumor microenvironment (TME) plays a critical regulatory role in bladder cancer (BLCA) progression and metastasis. Epithelial-mesenchymal transition (EMT) presents as an essential mechanism of invasion Accumulating pieces evidence indicated that several microenvironmental factors, including fibroblasts, endothelial, immune cells, induced EMT cells. As hallmark gene the process, calumenin (CALU) was previously reported to directly impact However, functions molecular mechanisms CALU have...
Abstract Background The role of glycolysis in tumorigenesis has received increasing attention and multiple glycolysis-related genes (GRGs) have been proven to be associated with tumor metastasis. Hence, we aimed construct a prognostic signature based on GRGs for clear cell renal carcinoma (ccRCC) explore its relationships immune infiltration. Methods Clinical information RNA-sequencing data ccRCC were obtained from Cancer Genome Atlas (TCGA) ArrayExpress datasets. Key finally selected...
Molecular features underlining the multistage progression of gastric lesions and development early cancer (GC) are poorly understood, restricting ability to GC prevention management.We portrayed proteomic landscape explored signatures associated with risk GC. Tissue profiling was conducted for a total 324 subjects. A case-control study performed in discovery stage (n=169) based on populations from Linqu, known high-risk area China. We then two-stage validation, including cohort Linqu (n =...