A5100347403- Cancer Genomics and Diagnostics
- Gastric Cancer Management and Outcomes
- Cancer Mechanisms and Therapy
- Esophageal and GI Pathology
- RNA modifications and cancer
- COVID-19 and Mental Health
- MicroRNA in disease regulation
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- Autophagy in Disease and Therapy
- Systemic Lupus Erythematosus Research
- Peptidase Inhibition and Analysis
- Neuroblastoma Research and Treatments
- COVID-19 epidemiological studies
- Vaccine Coverage and Hesitancy
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Endoplasmic Reticulum Stress and Disease
- Rheumatoid Arthritis Research and Therapies
- Breast Lesions and Carcinomas
- Cancer Immunotherapy and Biomarkers
- Colorectal and Anal Carcinomas
- Helicobacter pylori-related gastroenterology studies
- Cancer-related gene regulation
- Signaling Pathways in Disease
Xijing Hospital
2013-2025
Air Force Medical University
2016-2025
Central South University
2025
National Clinical Research Center for Digestive Diseases
2020-2025
Hebei Medical University
2014-2024
Second Hospital of Hebei Medical University
2014-2024
Third People's Hospital of Yunnan Province
2024
Sun Yat-sen University
2021
Sun Yat-sen University Cancer Center
2021
State Key Laboratory of Oncology in South China
2021
The ability to identify a specific cancer using minimally invasive biopsy holds great promise for improving the diagnosis, treatment selection, and prediction of prognosis in cancer. Using whole-genome methylation data from Cancer Genome Atlas (TCGA) machine learning methods, we evaluated utility DNA differentiating tumor tissue normal four common cancers (breast, colon, liver, lung). We identified markers training cohort 1,619 samples 173 matched adjacent samples. replicated our findings...
Abstract Background The current COVID-19 pandemic is effectively constrained by intensified public health measures in China, among which ubiquitous education plays a vital part. Objective This survey aims to understand the status quo acquisition of ongoing campaign university students. Methods We designed this cross-sectional investigated knowledge, attitude and practice (KAP) associated with students during their household isolation at peak pandemic. 872 undergraduates were recruited from...
Abstract Diffuse-type gastric cancer (DGC) and intestinal-type (IGC) are the major histological types of (GC). The molecular mechanism underlying DGC IGC differences poorly understood. In this research, we carry out multilevel proteomic analyses, including proteome, phospho-proteome, transcription factor (TF) activity profiles, 196 cases covering in Chinese patients. Integrative proteogenomic analysis reveals ARIDIA mutation associated with opposite prognostic effects between IGC, via...
The mechanisms underlying doxorubicin (Dox) resistance in colon cancer cells are not fully understood. MicroRNA (miRNA) play important roles tumorigenesis and drug resistance. However, the relationship between miRNA Dox has been previously explored. In this study, we utilized microRNA array real-time PCR to verify that miR-127, miR-195, miR-22, miR-137 were significantly down-regulated, while miR-21, miR-592 up-regulated both HT29/DOX LOVO/DOX cell lines. vitro viability assay showed...
Abstract Background: The COVID-19 pandemic has become a great threat to public health, which greatly impacted the study and life of undergraduate students in China. Objective: This aims perform survey their knowledge, attitude practice (KAP) associated with COVID-19. Methods: A cross-sectional was designed gather information regarding related KAP among undergraduates during home isolation outbreak. Subjects were recruited from 10 universities Shaanxi Province, Enrollees voluntarily submitted...
Pim-1 kinase is a proto-oncogene and its dysregulation contributes to tumorigenesis progression of variety malignancies. was suggested as therapeutic target cancers. The functional relevance the mechanism underlying in lung remained unclear. This study aimed investigate if has important functions non-small-cell cancer (NSCLC) by: 1) evaluating clinicopathologic significance through analysing expression 101 human NSCLCs tissues using quantitative PCR, Western Blot immunohistochemical studies,...
Background: The present study aimed to compare the feasibility and safety of early oral feeding (EOF) with traditional after radical total gastrectomy for gastric cancer. Methods: This retrospective included consecutive patients who underwent from April 2016 November 2018. These were divided into two groups, according their postoperative protocol: EOF group (n=314) (TOF) (n=433). Propensity score matching was used balance potential confounders, 276 selected each group. received diet on day...
The HLA-C*03:681 allele differs from HLA-C*03:02:02:01 by a single non-synonymous nucleotide change in exon 3.
Background/Objectives: Early diagnosis and treatment of rheumatoid arthritis (RA) are essential to reducing disability. However, the diagnostic criteria remain unclear, relying on clinical symptoms blood markers. Methods: Using high-performance liquid chromatography–mass spectrometry (HPLC-MS/MS) targeted detection, we evaluated 76 carnitine indicators (55 carnitines 21 corresponding ratios) in serum patients with RA investigate role RA. A total 359 (207 152 healthy controls) were included...
Although cisplatin is a very effective anticancer agent against several types of cancer including ovarian cancer, the mechanisms acquired resistance are not fully understood. By chronically exposing to cell lines, we established two cisplatin-resistant lines OV433 and TOV112D. Our results indicate that underlying their distinct. In cells, associated with increased expression mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1). knocking down MKP-1 by siRNA or inhibiting its...
Abstract Objectives For patients with rheumatoid arthritis (RA) in China, little is known of how their illness perceptions affect health-related quality life (HRQoL). The present study investigated associations between specific due to RA and HRQoL features. Methods 191 RA, were measured using the Brief Illness Perceptions Questionnaire (BIPQ) comprising 8 domains. was determined Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36). Multivariate linear regression analyses...
Objective To evaluate the performance of a DNA methylation-based digital droplet polymerase chain reaction (ddPCR) assay to detect aberrant methylation in cell-free (cfDNA) and determine its application detection hepatocellular carcinoma (HCC). Methods The present study recruited patients with liver-related diseases healthy control subjects. Blood samples were used for extraction cfDNA, which was then bisulfite converted extent quantified using ddPCR platform. Results A total 97 HCC, 80...
Objective: This study aimed to evaluate the associations between endoplasmic reticulum (ER) stress-related genes EIF2AK3/PERK, HSPA5/GRP78, and DDIT3/CHOP polymorphisms risk of lung cancer. Methods: Six single-nucleotide (SNPs) EIF2AK3, HSPA5, DDIT3 were genotyped in 620 cases controls using a MassARRAY platform. Results: The minor allele A rs6750998 was protective against cancer (p < 0.001), while alleles rs867529, rs391957, rs697221 all that may lead multiplied disease (rprs867529 = 0.002;...
Abstract Neurodegeneration is linked to the progressive loss of neural function and associated with several diseases. Hypoxia a hallmark in many these diseases, therapies have been developed treat this disease, including gene expression that should be tightly controlled avoid side effects. Cells experiencing hypoxia undergo series physiological responses are induced by activation various transcription factors. Modulation microRNA (miRNA) alter transcriptional regulation has demonstrated...
Acquired respiratory-digestive tract fistulas occur with abnormal communication between the airways and digestive tract, causing interflow of gas liquid. Despite advances in surgical methods development multimodal therapy recent years, patients acquired continue to exhibit unfavorable clinical outcomes. Therefore, order guide practice China, Respiratory Cancer Intervention Alliance Beijing Health Promotion Association organized a group experienced experts field develop this consensus...
Introduction Anlotinib hydrochloride is a multi-targeted receptor tyrosine kinase inhibitor that targets angiogenesis-related kinases and has already showed good safety efficacy in some solid tumours. However, evidence on the feasibility of anlotinib patients with stage IV gastric cancer scarce. Methods analysis This study single-armed single-centred clinical being designed to include 150 cancer. The patients’ demographics, pathological characteristics, test results blood, biochemistry...
Chronic HCV Patients taking PEG-IFN-α/R from different ethnic groups have probabilities of reaching a sustained viral response (SVR). There are many influence factors, such as genotype, IL-28B single-nucleotide polymorphisms (SNP), Fibrosis 4 index (FIB-4), and aspartate aminotransferase-to-platelet ratio (APRI) score. But the baseline factors in relation to treatment outcome was still not much clear. We evaluated data 231 chronic patients with or without liver fibrosis their antiviral...
Abstract Background Thoracic aortic aneurysm and dissection (TAAD) is a life‐threatening pathology that remains challenge worldwide. Up to 40% of TAAD cases are hereditary with complex heterogeneous genetic backgrounds. The purposes this study were determine the diagnostic rate patients TAAD, investigate molecular pathologic spectrum by next‐generation sequencing (NGS), explore future preclinical prospects diagnosis in at high ‐risk study. Methods NGS was used screen 15 genes associated 212...
There is limited experience of PD-1 antibody combined with other therapies in children. We aimed to explore the antitumor activity and safety monotherapy or combination regimens relapsed refractory pediatric cancer. This a retrospective-case study conducted two Chinese expert centers. The primary objective this was describe overall response rate (ORR) disease control (DCR). Secondary objectives included characterizing toxicities. Of 22 patients cancer who received inhibitors, median...