A5084175524- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Signaling Pathways in Disease
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Spondyloarthritis Studies and Treatments
- Galectins and Cancer Biology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Autoimmune and Inflammatory Disorders Research
- Toxin Mechanisms and Immunotoxins
- Bone and Joint Diseases
- Pulmonary Hypertension Research and Treatments
- Systemic Sclerosis and Related Diseases
- Atherosclerosis and Cardiovascular Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pharmacological Effects of Natural Compounds
- Immunodeficiency and Autoimmune Disorders
- Salivary Gland Disorders and Functions
- Cell Adhesion Molecules Research
- Cytokine Signaling Pathways and Interactions
- Psoriasis: Treatment and Pathogenesis
- Lymphoma Diagnosis and Treatment
- Vasculitis and related conditions
- Glycosylation and Glycoproteins Research
Air Force Medical University
2016-2025
Xijing Hospital
2016-2025
Zhejiang Center for Disease Control and Prevention
2024
Guizhou University of Finance and Economics
2024
Nanjing Medical University
2023
Jiangsu Province Hospital
2023
Chinese People's Liberation Army
2013-2022
National Natural Science Foundation of China
2022
State Council of the People's Republic of China
2021
Huaian First People’s Hospital
2021
Abstract Ferroptosis is a nonapoptotic cell death process that requires cellular iron and the accumulation of lipid peroxides. In progressive rheumatoid arthritis (RA), synovial fibroblasts proliferate abnormally in presence reactive oxygen species (ROS) elevated oxidation. Here we show, using collagen-induced (CIA) mouse model, imidazole ketone erastin (IKE), ferroptosis inducer, decreases fibroblast numbers synovium. Data from single-cell RNA sequencing further identify two groups have...
Abstract MRL/MpJ-Tnfrsf6lpr (MRL/MpJ-Faslpr; MRL-Faslpr) mice develop a spontaneous lupus syndrome closely resembling human systemic erythematosus. To define the role of IL-10 in regulation murine lupus, gene-deficient (IL-10−/−) MRL-Faslpr (MRL-Faslpr IL-10−/−) were generated and their disease phenotype was compared with littermates one or two copies an intact locus IL-10+/− IL-10+/+ mice, respectively). IL-10−/− developed severe earlier appearance skin lesions, increased lymphadenopathy,...
Orthotopic liver transplantation (OLT) is the only curative therapy of HCC with underlying cirrhosis, but due to metastasis and recurrence, its benefit limited a small population who meet strict selection criteria. We previously reported that Licartin ([131I]mAb HAb18G/CD147) was safe effective in treating patients, antigen, HAb18G/CD147, closely related invasion metastasis. Here, we randomized controlled trial assess post-OLT antirecurrence efficacy advanced patients. 60 patients HCC, were...
Objectives. To investigate whether cyclophilin A (CypA) can up-regulate the expression of MMP-2 and MMP-9 in monocytes/macrophages CD147 facilitates this regulation RA. Methods. Peripheral blood monocytes were isolated from RA patients differentiated into macrophages by M-CSF (15 ng/ml). Under CypA stimulation (200 ng/ml), protein release activation MMPs detected gelatin zymography invasion assay. Human monocyte cell line THP-1 cells selected for advanced searching potential interaction...
Abstract Primary biliary cholangitis (PBC) is an autoimmune liver disease with a strong hereditary component. Here, we report genome-wide association study that included 1,122 PBC cases and 4,036 controls of Han Chinese descent, subsequent replication in separate cohort 907 2,127 controls. Our results show 14 risk loci including previously identified 6p21 ( HLA-DRA DPB1 ), 17q12 ORMDL3 3q13.33 CD80 2q32.3 STAT1 / STAT4 3q25.33 IL12A 4q24 NF-κB ) 22q13.1 RPL3 SYNGR1 ). We also variants IL21 ,...
The Chinese systemic lupus erythematosus (SLE) treatment and research group (CSTAR) provides major clinical characteristics of SLE in China establishes a platform to provide resources for future basic studies. CSTAR originated as multicentre, consecutive, prospective design. data were collected online from 104 rheumatology centers, which covered 30 provinces China. registered patients required meet four or more the American College Rheumatology (ACR) criteria classification SLE. All centers...
SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape, compromising the effectiveness of existing vaccines neutralizing antibodies. An in-depth investigation on COVID-19 pathogenesis is urgently needed develop a strategy against variants. Here, we identified CD147 as universal receptor for its Meanwhile, Meplazeumab, humanized anti-CD147 antibody, could block cellular entry variants-alpha, beta, gamma, delta, with inhibition rates 68.7, 75.7, 52.1, 62.3% at 60...
This research investigates the role of inhibitor differentiation 2 (Id2) in synthesis pro-inflammatory cytokines, specifically interferon-γ (IFN-γ) and interleukin-17 (IL-17), by various subsets T cells, its pathogenic rheumatoid arthritis (RA). Flow cytometry was employed to assess T-cell activation Id2 expression 72 RA patients 23 healthy controls. In vitro, peripheral blood mononuclear cells were treated with either an or a co-stimulation inhibitor. An vivo collagen-induced (CIA) model...
CD147, a member of the immunoglobulin superfamily (IgSF), plays fundamental roles in intercellular interactions numerous pathological and physiological processes. Importantly, our previous studies have demonstrated that HAb18G/CD147 is novel hepatocellular carcinoma (HCC)-associated antigen, stimulates adjacent fibroblasts HCC cells to produce elevated levels several matrix metalloproteinases, facilitating invasion metastasis cells. In addition, has also been shown be universal cancer...
Efficacy of adalimumab for ankylosing spondylitis (AS) has been established Western populations but not in the Chinese population. This study is first to evaluate efficacy and safety patients with AS.Chinese adults active AS who had an inadequate response or were intolerant ≥1 non-steroidal anti-inflammatory drugs randomised 40 mg (N=229) matching placebo (N=115) subcutaneously every other week (EOW) 12 weeks, followed by a 12-week open-label EOW phase. The primary endpoint was percentage...
Objectives To estimate the prevalence of pulmonary arterial hypertension (PAH) and risk factors for PAH in patients registered Chinese SLE Treatment Research group (CSTAR) database, first online registry with systemic lupus erythematosus (SLE). Methods A prospective cross-sectional study was conducted using CSTAR registry. Resting transthoracic echocardiography used to artery pressure (PAP); defined as systolic PAP (PASP) ≥40 mmHg. Patients interstitial lung disease, valvular disease or...
Degradation of the basement membrane by MMPs (matrix metalloproteinases) is one most critical steps in tumour progression. CD147 a tumour-associated antigen that plays key regulatory role for MMP activities. In present study, mass spectrum analysis demonstrated purified native from human lung cancer tissue was N-glycosylated and contained series high-mannose complex-type N-linked glycan structures. Moreover, glycosylated existed exclusively as oligomers solution directly stimulated...
This study aimed to identify the long-term clinical outcomes and prognostic factors of patients with systemic lupus erythematosus (SLE)-associated pulmonary arterial hypertension (PAH) confirmed by right heart catheterisation.A multicentre prospective cohort SLE-associated PAH was established. Baseline follow-up records were collected. The primary end-point death. secondary exploratory treatment goal achievement (TGA), defined as an integrated outcome.In total, 310 enrolled from 14 centres....
Cyclophilin A (CyPA) is a ubiquitously distributed peptidylprolyl cis-trans isomerase (PPIase) that possesses diverse biological functions. Extracellular CyPA potent chemokine, which can directly induce leukocyte chemotaxis and contribute to the pathogenesis of inflammation-mediated diseases. Although it has been identified activity mediated through its cell surface signaling receptor CD147, role PPIase in this process disputable, underlying molecular mechanism still poorly understood. In...
The occurrence of neutrophils at the pannus-cartilage border is an important phenomenon for understanding pathogenesis rheumatoid arthritis (RA). Matrix metalloproteinases (MMPs) are predominant enzymes responsible cartilage degradation. present article studied expression CD147 on and its potential role in neutrophil chemotaxis, MMPs production invasiveness fibroblast-like synoviocytes (FLS). results flow cytometry revealed that mean fluorescence intensity peripheral blood from RA patients...
// Zhi-guang Fu 1, * , Li Wang 2, Hong-yong Cui Jian-long Peng 3 Shi-jie 1 Jie-jie Geng Ji-de Liu Fei Feng Song Ling Ping Zhu 4 Jian-li Jiang Zhi-nan Chen Cell Engineering Research Center & Department of Biology, State Key Laboratory Cancer National Discipline Fourth Military Medical University, Xi’an, P.R. China 2 Pharmacogenomics, School Pharmacy, Drug Discovery and Design Center, Research, Shanghai Institute Materia Medica, Chinese Academy Sciences, Shanghai, Clinical...
Objectives To investigate both the prevalence and clinical characteristics of serositis in Chinese patients with systemic lupus erythematosus (SLE) a large cohort SLE Treatment Research group (CSTAR) database. Methods A prospective cross-sectional study was conducted based on data from CSTAR registry. Serositis defined according to 1999 revised American College Rheumatology (ACR) criteria for – that is, pleuritis/pleural effusion and/or pericarditis/pericardial detected by echocardiography,...