A5005496208- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Gut microbiota and health
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Epigenetics and DNA Methylation
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Cancer-related gene regulation
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Mycobacterium research and diagnosis
- Colorectal Cancer Treatments and Studies
- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related Molecular Pathways
- Cancer, Lipids, and Metabolism
- Circular RNAs in diseases
- Ubiquitin and proteasome pathways
- Immune Cell Function and Interaction
- Colorectal Cancer Surgical Treatments
- Gastroesophageal reflux and treatments
- PI3K/AKT/mTOR signaling in cancer
Shanghai Jiao Tong University
2016-2025
Renji Hospital
2016-2025
Shanghai Cancer Institute
2015-2025
Shandong Jianzhu University
2024-2025
Shanghai Institute of Hematology
2015-2024
State Key Laboratory of Oncogene and Related Genes
2015-2024
Hebei University of Chinese Medicine
2024
Tongji University
2013-2024
Sir Run Run Shaw Hospital
2018-2024
Zhejiang University
2018-2024
Several of the thousands human long noncoding RNAs (lncRNAs) have been functionally characterized, yet their potential involvement in hepatocellular carcinoma (HCC) remains poorly understood. LncRNA-HOXD-AS1 was identified by microarray and validated real-time PCR. The clinicopathological significance HOXD-AS1 analyzed Kaplan-Meier method. Chromatin immunoprecipitation conducted to examine mechanism upregulation. role HCC cells assessed both vitro vivo. ceRNA function evaluated RNA...
Abnormalities in the STAT3 pathway are involved oncogenesis of several cancers. However, mechanism by which dysregulated signaling contributes to progression human colorectal cancer (CRC) has not been elucidated, nor role JAK, physiological activator STAT3, evaluated. To investigate both JAK and CRC progression, we inhibited with AG490 depleted a SiRNA. Our results demonstrate that JAK1 2 cell growth, survival, invasion, migration through regulation gene expression, such as Bcl-2, p16ink4a,...
A variant upstream of human leukocyte antigen C (HLA-C) shows the most significant genome-wide effect on HIV control in European Americans and is also associated with level HLA-C expression. We characterized differential cell surface expression levels all common allotypes tested directly for effects outcomes infection 5243 individuals. Increasing was protection against multiple independently individual HLA allelic both African Americans, regardless their distinct frequencies linkage...
Objective A close relationship between gut microbiota and some chronic liver disorders has recently been described. Herein, we systematically performed a comparative analysis of the microbiome in primary biliary cholangitis (PBC) healthy controls. Design We first conducted cross-sectional study 60 ursodeoxycholic acid (UDCA) treatment-naïve patients with PBC 80 matched Second, an independent cohort composed 19 34 controls was used to validate results. Finally, prospective subgroup 37 who...
Long noncoding RNAs (lncRNA) play a role in carcinogenesis. However, the function of lncRNAs human gastric cancer remains largely unknown. In this study, we identified novel lncRNA, GClnc1, which was upregulated and associated with tumorigenesis, tumor size, metastasis, poor prognosis cancer. GClnc1 affected cell proliferation, invasiveness, metastasis multiple models. Mechanistically, bound WDR5 (a key component histone methyltransferase complex) KAT2A acetyltransferase, acted as modular...
Abstract Background Epigenetic alterations are involved in various aspects of colorectal carcinogenesis. N 6 -methyladenosine (m A) modifications RNAs emerging as a new layer epigenetic regulation. As the most abundant chemical modification eukaryotic mRNA, m A is essential for regulation mRNA stability, splicing, and translation. Alterations regulatory genes play important roles pathogenesis variety human diseases. However, whether this participates glucose metabolism cancer (CRC) remains...
Long non-coding RNAs (lncRNAs) contribute to colorectal cancer (CRC). However, the role of lncRNAs in CRC metabolism, especially glucose metabolism remains largely unknown. In this study, we identify a lncRNA, GLCC1, which is significantly upregulated under starvation cells, supporting cell survival and proliferation by enhancing glycolysis. Mechanistically, GLCC1 stabilizes c-Myc transcriptional factor from ubiquitination direct interaction with HSP90 chaperon further specifies modification...
Abstract Purpose: Gut microbiota have been implicated in the development of colorectal cancer. We evaluated utility fecal bacterial marker candidates identified by our metagenome sequencing analysis for cancer diagnosis. Experimental Design: Subjects (total 439; 203 and 236 healthy subjects) from two independent Asian cohorts were included. Probe-based duplex quantitative PCR (qPCR) assays established quantification candidates. Results: Candidates sequencing, including Fusobacterium...
Objective The significance of the liver-microbiome axis has been increasingly recognised as a major modulator autoimmunity. aim this study was to take advantage large well-defined corticosteroids treatment-naïve group patients with autoimmune hepatitis (AIH) rigorously characterise gut dysbiosis compared healthy controls. Design We performed cross-sectional individuals AIH (n=91) and matched controls (n=98) by 16S rRNA gene sequencing. An independent cohort 28 34 analysed validate results....
It is increasingly evident that long noncoding RNAs (lncRNA) have causative roles in carcinogenesis. In this study, we report findings implicating a novel lncRNA gastric cancer, termed GAPLINC (gastric adenocarcinoma predictive intergenic RNA), based on the use of global microarray and situ hybridization (ISH) analyses to identify aberrantly expressed human cancer specimens. 924-bp-long highly tissues. suppression with gene expression profiling cells revealed alterations cell migration...
Abstract Foxp3+CD4+ regulatory T (Treg) cells inhibit immune responses and temper inflammation. IL-17+CD4+ (Th17) mediate inflammation of autoimmune diseases. A small population IL-17+Foxp3+CD4+ has been observed in peripheral blood healthy human beings. However, the biology remains poorly understood humans. We investigated their phenotype, cytokine profile, generation, pathological relevance patients with ulcerative colitis. that high levels were selectively accumulated colitic...
Objective There is a need for early detection of colorectal cancer (CRC) at precancerous-stage adenoma. Here, we identified novel faecal bacterial markers diagnosing Design This study included 1012 subjects (274 CRC, 353 adenoma and 385 controls) from two independent Asian groups. Candidate were by metagenomics validated targeted quantitative PCR. Results Metagenomic analysis ‘ m3 ’ Lachnoclostridium sp., Fusobacterium nucleatum ( Fn ) Clostridium hathewayi Ch to be significantly enriched in...
Objective Microbiota disorder promotes chronic inflammation and carcinogenesis. High glycolysis is associated with poor prognosis in patients colorectal cancer (CRC). However, the potential correlation between gut microbiota glucose metabolism unknown CRC. Design 18 F-FDG ( F-fluorodeoxyglucose) PET (positron emission tomography)/CT image scanning data PCR analysis were performed to measure metabolic alterations 33 Multiple models, Seahorse assay established assess role of long non-coding...