A5063481218- Neurogenesis and neuroplasticity mechanisms
- MicroRNA in disease regulation
- Diet and metabolism studies
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Extracellular vesicles in disease
- Mesenchymal stem cell research
- Ubiquitin and proteasome pathways
- Metabolomics and Mass Spectrometry Studies
- Circular RNAs in diseases
- Birth, Development, and Health
- Cell death mechanisms and regulation
- Lipoproteins and Cardiovascular Health
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Advanced Proteomics Techniques and Applications
- Immune cells in cancer
- Genetic Syndromes and Imprinting
- Cancer-related Molecular Pathways
- Pluripotent Stem Cells Research
- Alzheimer's disease research and treatments
- Bone Metabolism and Diseases
- dental development and anomalies
- Nerve injury and regeneration
Army Medical University
2018-2025
Xinqiao Hospital
2018-2025
Shandong First Medical University
2025
Shandong Provincial Hospital
2025
First Affiliated Hospital Zhejiang University
2024-2025
University of Cambridge
2012-2024
Wellcome/MRC Cambridge Stem Cell Institute
2015-2024
Medical Research Council
2005-2024
Aston University
2022-2024
Third Xiangya Hospital
2024
We have recently described a molecular gatekeeper of the hypothalamic-pituitary-gonadal axis with observation that G protein-coupled receptor 54 (GPR54) is required in mice and men for pubertal onset pulsatile luteinizing hormone (LH) follicle-stimulating (FSH) secretion to occur. In present study, we investigate possible central mode action GPR54 kisspeptin ligand. First, show transcripts are colocalized gonadotropin-releasing (GnRH) neurons mouse hypothalamus, suggesting kisspeptin,...
Abstract Background Epigenetic alterations are involved in various aspects of colorectal carcinogenesis. N 6 -methyladenosine (m A) modifications RNAs emerging as a new layer epigenetic regulation. As the most abundant chemical modification eukaryotic mRNA, m A is essential for regulation mRNA stability, splicing, and translation. Alterations regulatory genes play important roles pathogenesis variety human diseases. However, whether this participates glucose metabolism cancer (CRC) remains...
Pyroptosis is a new programmed cell death discovered in recent years. plays an important role various diseases. Nevertheless, there are few bibliometric analysis systematically studies this field. We aimed to visualize the research hotspots and trends of pyroptosis using help understand future development basic clinical research.The articles reviews regarding were culled from Web Science Core Collection. Countries, institutions, authors, references keywords field visually analyzed by...
Background: Acute ischemic stroke (AIS) is a leading cause of disability and mortality worldwide. Prediction penumbra existence after AIS crucial for making decision on reperfusion therapy. Yet fast, inexpensive, simple, noninvasive predictive biomarker the poststroke with clinical translational potential still lacking. We aim to investigate whether CircOGDH (circular RNA derived from oxoglutarate dehydrogenase) in patients its role neuronal damage. Methods: was screened middle cerebral...
Remyelination following central nervous system demyelination is essential to prevent axon degeneration. However, remyelination ultimately fails in demyelinating diseases such as multiple sclerosis. This failure of likely mediated by many factors, including changes the extracellular signalling environment. Here, we examined expression matrix molecule fibronectin on injury and how this affects oligodendrocytes progenitors. In toxin-induced lesions undergoing efficient remyelination, was...
Oligodendrocytes derive from progenitors (OPCs) through the interplay of epigenomic and transcriptional events. By integrating high-resolution methylomics, RNA-sequencing, multiple transgenic lines, this study defines role DNMT1 in developmental myelination. We detected hypermethylation genes related to cell cycle neurogenesis during differentiation OPCs, yet genetic ablation Dnmt1 resulted inefficient OPC expansion severe hypomyelination associated with ataxia tremors mice. This phenotype...
Background: Exosomes in cardiovascular diseases (CVDs) have become an active research field with substantial value and potential. Nevertheless, there are few bibliometric studies this field. We aimed to visualize the hotspots trends of exosomes CVDs using a analysis help understand future development basic clinical research. Methods: The articles reviews regarding were culled from Web Science Core Collection, knowledge maps generated CiteSpace VOSviewer software. Results: A total 1,039...
Alzheimer's disease (AD), the most common neurodegenerative disorder, is characterized by accumulation of amyloid-β (Aβ) peptide and hyperphosphorylated tau protein. Accumulating evidence has revealed that slow progressive deterioration AD associated with oxidative stress chronic inflammation in brain. Nuclear factor erythroid 2- (NF-E2-) related 2 (Nrf2), which acts through Nrf2/ARE pathway, a key regulator antioxidant anti-inflammatory response. Although recent data show link between Nrf2...
Objective: To determine the morbidity, mortality, and pathologic outcomes of transanal total mesorectal resection (taTME) versus laparoscopic excision (laTME) among patients with rectal cancer clinical stage I to III below peritoneal reflection. Background: Studies sufficient numbers allowing acceptance taTME for are lacking. Thus, we launched a randomized trial compare safety efficacy laTME. Methods: A randomized, open-label, phase 3, noninferiority was performed at 16 different hospitals...
The control of diseases related to atrial fibrillation (AF) may reduce the occurrence AF, delay progression, and complications, which is beneficial prevention treatment AF. An increasing number studies have shown that AF associated with depression. However, date, there has not been a bibliometric analysis examine this field systematically. Our study aimed visualize publications determine hotspots frontiers in research on depression provide guidance reference for further study.Publications...
Importance Previous studies have demonstrated the advantages of short-term histopathological outcomes and complications associated with transanal total mesorectal excision (TME) compared laparoscopic TME. However, long-term oncological TME remain ambiguous. This study aims to compare 3-year disease-free survival Objective To evaluate between in patients rectal cancer. Design, Setting, Participants randomized, open-label, noninferiority, phase 3 clinical trial was performed 16 different...
Transient neonatal diabetes mellitus (TNDM) is a rare inherited diabetic syndrome apparent in the first weeks of life and again during early adulthood. The relative contributions reduced islet β cell number impaired function to observed hypoinsulinemia are unclear. inheritance pattern this imprinted disorder implicates overexpression one or both genes within TNDM locus: ZAC, which encodes proapoptotic zinc finger protein, HYMAI, an untranslated mRNA. To investigate consequences for...
Transient neonatal diabetes mellitus (TNDM) is a rare inherited diabetic syndrome apparent in the first weeks of life and again during early adulthood. The relative contributions reduced islet β cell number impaired function to observed hypoinsulinemia are unclear. inheritance pattern this imprinted disorder implicates overexpression one or both genes within TNDM locus: ZAC, which encodes proapoptotic zinc finger protein, HYMAI, an untranslated mRNA. To investigate consequences for...
The Sox family of transcription factors have been widely studied in the context oligodendrocyte development. However, comparatively little is known about role Sox2, especially during CNS remyelination. Here we show that expression Sox2 occurs progenitor cells (OPCs) rodent models myelination and activated adult OPCs responding to demyelination, also detected multiple sclerosis lesions. In normal white matter both mice rats, it neither expressed by nor oligodendrocytes (although a...
In response to the microenvironment, microglia may polarize into either an M1 pro-inflammatory phenotype, exacerbating neurotoxicity, or M2 anti-inflammatory conferring neuroprotection. Betulinic acid (BA) is a naturally pentacyclic triterpenoid with considerable properties. Here, we aim investigate potential effects of BA on microglial phenotype polarization and reveal underlying mechanisms action. First, confirmed that promoted inhibited in lipopolysaccharide (LPS)-stimulated BV-2 cells....
Exosomes contribute to cell–cell communications. Emerging evidence has shown that microglial exosomes may play crucial role in regulation of neuronal functions under ischemic conditions. However, the underlying mechanisms microglia-derived exosome biosynthesis are largely unknown. Herein, we reported PDE1-B expression was progressively elevated peri-infarct region after focal middle cerebral artery occlusion. By an oxygen-glucose-deprivation (OGD) model cells, found inhibition by vinpocetine...
Spinal cord injury (SCI) is a devastating disease that causes extensive damage to oligodendrocytes and neurons leading demyelination axonal degeneration. In this study, we co-transplanted cell grafts containing oligodendrocyte progenitor cells (OPCs) derived from human-induced pluripotent stem (iPSCs) combined with human umbilical vein endothelial (HUVECs), which were reported promote OPCs survival migration, into rat contusion models functional recovery after SCI.
Many previous studies have attempted to gain insight into the underlying pathophysiology of schizophrenia by studying postmortem brain tissues patients. However, such analyses can be confounded artifactual features this approach as lengthy agonal state and interval times. As several aspects are also manifested at peripheral level in proliferating cell types, we studied disorder through systematic transcriptomic proteomic skin fibroblasts biopsied from living We performed comparative...
Objective: The E3 ubiquitin ligase RNF6 (RING-finger protein 6) plays a crucial role in carcinogenesis. However, the copy number and expression of were rarely reported colorectal cancer. We aimed to explore mechanical, biological, clinical cancer initiation progression.Design: analyzed from Tumorscape Cancer Genome Atlas (TCGA) datasets. Gene expressions examined by real-time PCR, Western blot, immunohistochemical staining. profiling studies performed identify pivotal genes regulated RNF6....
Objectives Strontium (Sr 2+ ) is a crucial trace element in humans, mainly present the bones. We investigated effects of Sr on human periodontal ligament stem cell (hPDLSC) proliferation and osteogenesis relevant pathways. Methods hPDLSCs were harvested from extracted premolars characterized by flow cytometry, then cultured treated with various concentrations. Cell-counting kit-8 (CCK-8) assays used to assess hPDLSC proliferation, alkaline phosphatase (ALP) staining, Alizarin red S ALP...