A5022527790- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Quantum Mechanics and Applications
- Cancer-related molecular mechanisms research
- Neuroinflammation and Neurodegeneration Mechanisms
- Quantum Electrodynamics and Casimir Effect
- Cerebrovascular and Carotid Artery Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- RNA Research and Splicing
- Statistical Mechanics and Entropy
- Quantum Information and Cryptography
- Cosmology and Gravitation Theories
- Hip and Femur Fractures
- Aortic Disease and Treatment Approaches
- Black Holes and Theoretical Physics
- Relativity and Gravitational Theory
- Moyamoya disease diagnosis and treatment
- Ferroptosis and cancer prognosis
First Affiliated Hospital of Jinan University
2021-2025
Fudan University
2024
Background: Acute ischemic stroke (AIS) is a leading cause of disability and mortality worldwide. Prediction penumbra existence after AIS crucial for making decision on reperfusion therapy. Yet fast, inexpensive, simple, noninvasive predictive biomarker the poststroke with clinical translational potential still lacking. We aim to investigate whether CircOGDH (circular RNA derived from oxoglutarate dehydrogenase) in patients its role neuronal damage. Methods: was screened middle cerebral...
Exosomes contribute to cell–cell communications. Emerging evidence has shown that microglial exosomes may play crucial role in regulation of neuronal functions under ischemic conditions. However, the underlying mechanisms microglia-derived exosome biosynthesis are largely unknown. Herein, we reported PDE1-B expression was progressively elevated peri-infarct region after focal middle cerebral artery occlusion. By an oxygen-glucose-deprivation (OGD) model cells, found inhibition by vinpocetine...
BACKGROUND: Acute ischemic stroke disrupts communication between neurons and blood vessels in penumbral areas. How cooperate to achieve blood-brain barrier repair remains unclear. Here, we reveal crosstalk endothelial cells (ECs) mediated by circular RNA originating from oxoglutarate dehydrogenase (CircOGDH). METHODS: We analyzed clinical data patients with acute explore the relationship CircOGDH levels hemorrhagic transformation events. In addition, a middle cerebral artery occlusion...
We aimed to develop and validate a new nomogram for predicting the risk of intracranial hemorrhage (ICH) in patients with acute ischemic stroke (AIS) after intravenous thrombolysis (IVT).A retrospective study enrolled 553 AIS treated IVT. The were randomly divided into two cohorts: training set (70%, n = 387) testing (30%, 166). factors predictive filtered using multivariable logistic regression analysis. performance was assessed based on area under receiver operating characteristic curve...
Abstract Small extracellular vesicles (sEVs) contain abundant circular RNAs (circRNAs) and are involved in cellular processes, particularly hypoxia. However, the process that packaging of circRNAs into neuronal sEVs under hypoxia is unclear. This study revealed spatial mechanism Fused Sarcoma protein (FUS) facilitates loading functional neurons. It found FUS translocated from nucleus to cytoplasm more enriched hypoxic than normal sEVs. Cytoplasmic formed aggregates with marker CD63...
Abstract Observable scattering processes entail emission-absorption of soft photons. As these degrees freedom go undetected, some information is lost. Whether this can be recovered in the observation hard particles, depends actual pattern scrambling information. We compute electron and photon by tripartite mutual terms 2-Renyi entropy, find a finite amount present. show that byproduct decoherence achieved system its interaction with environment, due to photons fully unitary processes.
Observable scattering processes entail emission-absorption of soft photons. As these degrees freedom go undetected, some information is lost. Whether this can be recovered in the observation hard photons, depends actual pattern scrambling information. We compute photon by tripartite mutual terms 2-Renyi entropy, and find a finite amount present. The developed procedure thus sheds novel light on black hole loss paradox, showing that byproduct decoherence achieved system its interaction with...
Black holes are a recently observed theoretical prediction of General Relativity, characterized by event horizons, from which information cannot escape. Examined through the lenses quantum mechanics, they can radiate at definite temperature inverse to their mass and horizon radius. Hawking radiation, whose spectrum was calculated considering particles scattering off black holes, is connected paradox loss falling into them. Information become non-fungible, due scrambling. We demonstrate this...