A5100355153- Liver Disease Diagnosis and Treatment
- Peroxisome Proliferator-Activated Receptors
- Autophagy in Disease and Therapy
- Adipose Tissue and Metabolism
- Pancreatic function and diabetes
- Pain Mechanisms and Treatments
- Endoplasmic Reticulum Stress and Disease
- Botulinum Toxin and Related Neurological Disorders
- Liver Disease and Transplantation
- Metabolism, Diabetes, and Cancer
- Nutrition and Health in Aging
- Neuroinflammation and Neurodegeneration Mechanisms
- Hepatocellular Carcinoma Treatment and Prognosis
- RNA Research and Splicing
- MicroRNA in disease regulation
- Aquaculture Nutrition and Growth
- Meat and Animal Product Quality
- Mitochondrial Function and Pathology
- Electron Spin Resonance Studies
- Diet and metabolism studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet, Metabolism, and Disease
- Parkinson's Disease Mechanisms and Treatments
- Pharmacological Effects of Natural Compounds
- Platelet Disorders and Treatments
Chongqing Medical University
2025
Children's Hospital of Chongqing Medical University
2025
Ministry of Industry and Information Technology
2025
Harbin Engineering University
2025
Hansoh Pharma (China)
2021-2024
Beijing Anding Hospital
2015-2024
National Center for Drug Screening
2018-2024
Shanghai Institute of Materia Medica
2018-2024
Tangshan People's Hospital
2023-2024
Anhui Polytechnic University
2023-2024
Recent studies suggested that muscle mass and strength may independently or synergistically affect aging-related health outcomes in older adults; however, prospective data on mortality the general population are sparse.We aimed to prospectively examine individual joint associations of low with all-cause a nationally representative sample. This study included 4449 participants age 50 yr from National Health Nutrition Examination Survey 1999 2002 public use 2011 linked files. Weighted...
Blood-brain barrier (BBB) damage can be a result of central nervous system (CNS) diseases and may cause CNS deterioration. However, there are still many unknowns regarding effective targeted therapies for maintaining BBB integrity during ischemia/reperfusion (I/R) injury. In this study, we demonstrate that the circular RNA FoxO3 (circ-FoxO3) promotes autophagy via mTORC1 inhibition to attenuate collapse under I/R. Upregulation circ-FoxO3 autophagic flux were detected in brain microvessel...
Nonalcoholic steatohepatitis (NASH) is an advanced stage of nonalcoholic fatty liver disease (NAFLD) with serious consequences that currently lacks approved pharmacological therapies. Recent studies suggest the close relationship between pathogenesis NAFLD and dysregulation RNA splicing machinery. Here, we reveal death-associated protein kinase-related apoptosis-inducing kinase-2 (DRAK2) markedly upregulated in livers both NAFLD/NASH patients diet-fed mice. Hepatic deletion DRAK2 suppresses...
Exosomes contribute to cell–cell communications. Emerging evidence has shown that microglial exosomes may play crucial role in regulation of neuronal functions under ischemic conditions. However, the underlying mechanisms microglia-derived exosome biosynthesis are largely unknown. Herein, we reported PDE1-B expression was progressively elevated peri-infarct region after focal middle cerebral artery occlusion. By an oxygen-glucose-deprivation (OGD) model cells, found inhibition by vinpocetine...
Impeded autophagy can impair pancreatic β cell function by causing apoptosis, of which DAP-related apoptosis-inducing kinase-2 (DRAK2) is a critical regulator. Here, we identified marked up-regulation DRAK2 in tissue across humans, macaques, and mice with type 2 diabetes (T2D). Further studies showed that conditional knockout (cKO) cells protected against high-fat diet feeding along sustained mitochondrial function. Phosphoproteome analysis isolated mouse primary islets revealed directly...
Summary Data on the prevalence of obstructive sleep apnea in subjects with type 2 diabetes mellitus China is scarce. We conducted a multi‐centre, cross‐sectional study involving 12 hospitals from six regional cities to investigate hospitalized patients and explore association between related risk factors, diabetic complications comorbidities China. Each hospital recruited at least 70 consecutive who were admitted endocrinology ward. A total 880 participants enrolled administered overnight...
Platelet prothrombinase activity and microvesicle (MV) generation were measured in four patients from three unrelated families with a life‐long bleeding disorder associated slightly prolonged time isolated defective serum prothrombin consumption, without platelet function abnormality or von Willebrand factor defect. MV was reduced all the either after thrombin plus collagen A23187 calcium ionophore stimulation, whereas, at variance Scott syndrome, normal. This constitutes new disorder, which...
The nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome has been linked to sterile inflammation, which is involved in ischemic injury myocardial cells. Pigment epithelium-derived factor (PEDF) a multifunctional secreted glycoprotein with many biological activities, such as anti-inflammatory, antioxidant and anti-angiogenic properties. However, it not known whether how PEDF acts regulate the activation of NLRP3 cardiomyocytes. In present study, we used...
To tackle the problems associated with high-dose dexamethasone (HD-DXM) in patients immune thrombocytopenia (ITP).To compare efficacy of HD-DXM or without low-dose maintenance untreated ITP patients.Dexamethasone (40 mg/day) was given 4-day pulses every 14 days for 3 cycles 61 ITP. Among them, 30 cases were (0.035 mg/kg per day) between pulsed and after courses (HD-DXM-M group) another 31 did not receive (HD-DXM-nM group). The control group comprised who received prednisone (prednisone...
Aims . Emerging evidence has suggested a mechanistic link from vitamin D metabolism to glucose and insulin homeostasis. This study is aimed at specifically quantifying the direct effects of supplementation on indexes homeostasis as well incidence type 2 diabetes (T2D) among nondiabetic adults. Methods We systematically searched randomized controlled trials (RCTs) in adults PubMed, EMBASE, CENTRAL. Random-effects meta-analysis was conducted pool estimates. Results Our included 47 RCTs...
Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes, and its progression significantly worsens patient's quality life. This study investigated prevalence risk factors associated with DPN in a large sample Beijing individuals type 1 2 as well compared diagnostic methods for DPN. A total 2,048 diabetic patients from 13 centers were assessed through questionnaires examination. Patients divided into group suspected DPN/non-DPN group. The demographic, clinical...
Genetic alterations play a pivotal role in leukemic clonal transformation, significantly influencing disease pathogenesis and clinical outcomes. Here, we report novel fusion gene investigate its pathogenic acute lymphoblastic leukemia (ALL). We engineer transposon transfection system expressing the TOP2B::AFF2 transcript introduce it into Ba/F3 cells. Functional studies, including proliferation, cell cycle, apoptosis assays, were conducted to assess gene's impact. In vitro assays reveal that...
Pigment epithelial-derived factor (PEDF) is known to exert diverse physiological activities. Previous studies suggest that hypoxia could induce mitophagy. Astoundingly, under hypoxic condition, we found PEDF decreased the mitochondrial density of cardiomyocytes. In this study, evaluated whether decrease and play a protective role in cardiomyocytes via promoting Immunostaining western blotting were used analyze mitophagy Gas chromatography‑mass spectrometry ELISA levels palmitic acid...
Abstract Background Prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing in developing countries, but its causes are not known. We aimed to ascertain the prevalence and determinants NAFLD a new largely unmedicated population‐based cohort from rapidly gentrifying region Pinggu, China. Methods randomized cluster sampled 4002 Pinggu residents aged 26 76 years. Data 1238 men 1928 women without significant alcohol drinking or hepatitis virus B C infection were analysed. was...