A5081597958- Advancements in Battery Materials
- Extraction and Separation Processes
- Recycling and Waste Management Techniques
- Cancer-related molecular mechanisms research
- Nonlinear Partial Differential Equations
- MicroRNA in disease regulation
- Advanced Battery Materials and Technologies
- RNA modifications and cancer
- Nanopore and Nanochannel Transport Studies
- Advanced biosensing and bioanalysis techniques
- Advanced Mathematical Modeling in Engineering
- Nonlinear Differential Equations Analysis
- Molecular Biology Techniques and Applications
- Antibiotic Resistance in Bacteria
- Quality and Safety in Healthcare
- Respiratory Support and Mechanisms
- Circular RNAs in diseases
- RNA Interference and Gene Delivery
- Advanced Wireless Communication Techniques
- Antibiotic Use and Resistance
- CRISPR and Genetic Engineering
- Ion channel regulation and function
- Genetic Associations and Epidemiology
- Wireless Communication Networks Research
- RNA and protein synthesis mechanisms
The Third Affiliated Hospital of Zhejiang Chinese Medical University
2024-2025
Zhejiang University
2025
Soochow University
2011-2024
First Affiliated Hospital of Soochow University
2011-2024
First Affiliated Hospital of Xi'an Jiaotong University
2022-2024
Harbin Engineering University
2020-2024
Wenzhou Medical University
2014-2024
Affiliated Eye Hospital of Wenzhou Medical College
2014-2024
Southwest University
2024
Qingdao University
2024
RNA-protein interactions are pivotal in fundamental cellular processes such as translation, mRNA processing, early development, and infection by RNA viruses. However, spite of the central importance these interactions, few approaches available to analyze them rapidly vivo. We describe a yeast genetic method detect which binding bifunctional each two hybrid proteins activates transcription reporter gene demonstrate that this three-hybrid system enables rapid, phenotypic detection specific...
<h3>Background/aims</h3> To investigate the prognostic values of putative hepatic stem/progenitor cell (HSC/HPC) biomarkers in patients with hepatocellular carcinoma (HCC). <h3>Methods</h3> Fourteen related to HSCs/HPCs or tumour angiogenesis were assessed by qRT-PCR and then validated tissue microarrays (TMAs) three independent cohorts HCC undergoing curative resection (n=67, 314 73). <h3>Results</h3> Most found be overexpressed recurrent quantitative reverse transcription–PCR (qRT–PCR)....
In this paper, we developed an efficient and environment-friendly approach, the molten-salt-electrolysis (MSE), to recover lithium cobalt from spent LiCoO2-based lithium-ion batteries (LIBs). Unlike conventional ways that employ strong acid lixiviants reducing agents, LiCoO2 was electrochemically reduced either CoO or Co under controlled potentials at cathode, releasing Li2O into molten salts where combined with CO2 generated carbon anode produce Li2CO3. After electrolysis, CoO/Co Li2CO3...
An ammonium chloride roasting approach can convert lithium metal oxides to water-soluble and transition chlorides at 300 °C, promising an energy-efficient environmentally benign way recover end-of-life lithium-ion batteries. Unlike conventional chlorination processes, the of LiCoO2 using NH4Cl as both reducing agents is complex, thus more efforts such thermodynamics underlying mechanism are required be understood. This paper aims study process by comprehensive thermodynamic analysis a...
Nonalcoholic steatohepatitis (NASH) is an advanced stage of nonalcoholic fatty liver disease (NAFLD) with serious consequences that currently lacks approved pharmacological therapies. Recent studies suggest the close relationship between pathogenesis NAFLD and dysregulation RNA splicing machinery. Here, we reveal death-associated protein kinase-related apoptosis-inducing kinase-2 (DRAK2) markedly upregulated in livers both NAFLD/NASH patients diet-fed mice. Hepatic deletion DRAK2 suppresses...
Spent lithium-ion batteries (LIBs) and benzene-containing polymers (BCPs) are two major pollutants that cause serious environmental burdens. Herein, spent LIBs BCPs copyrolyzed in a sealed reactor to generate Li2CO3, metals, and/or metal oxides without emitting toxic benzene-based gases. The use of closed allows the sufficient reduction reaction between BCP-derived polycyclic aromatic hydrocarbon (PAH) gases lithium transition oxides, achieving Li recovery efficiencies 98.3, 99.9, 97.5% for...
MicroRNAs (miRNAs) are a class of post-transcriptional gene regulators involved in various physiological processes including carcinogenesis, and they have emerged as potential targets for tumor theranostics. However, the employment antisense oligonucleotides, termed anti-miRs, antagonizing miRNA functions vivo has largely been impeded by lack effective delivery carriers. Here, we describe development polyamidoamine (PAMAM) dendrimer polyethylene glycol (PEG)-functionalized nanographene oxide...
Efficiently recycling end-of-life lithium-ion batteries (LIBs) has been pursued in recent years to reduce energy consumption and secondary waste. In this paper, silicon tetrachloride (SiCl4)-assisted roasting was developed recover LiCl, CoCl2, Co3O4 from spent lithium cobalt oxide (LiCoO2) batteries. At 500 °C a SiCl4/LiCoO2 mass ratio of 3:1, 95.6% Co recovered as CoCl2 98.4% Li LiCl. When the 0.7:1, 24.6% form remaining Co3O4, accompanied by leaching rate 95.6%. LiCoO2 resynthesized...
Recycling anode materials from spent lithium-ion batteries (LIBs) plays a significant role in relieving the environmental pollution and shortage of graphite lithium resources. Most current routes employed mineral acids to leach out Li anode, inevitably producing hazardous hydrofluoric acid (HF) because some exists form fluoride (LiF). In this study, we employ NaOH roasting approach, by which LiF is converted NaF LiOH at 350 °C thereby avoids generation HF. After roasting, can be separated...
Abstract Transient receptor potential vanilloid 1 (TRPV1) ion channel is a classic analgesic target, but antagonists of TRPV1 failed in clinical trials due to their side effects like hyperthermia. Here we rationally engineer peptide s-RhTx as positive allosteric modulator (PAM) TRPV1. Patch-clamp recordings demonstrate selectively potentiated activation. also slows down capsaicin-induced desensitization the presence calcium cause more influx TRPV1-expressing cells. In addition, our...
A major challenge for cancer chemotherapy is the development of safe and clinically effective chemotherapeutic agents. With its low toxicity profile, sophocarpine (SC), a naturally occurring tetracyclic quinolizidine alkaloid derived from Sophora alopecuroides L, has shown promising therapeutic properties, including anti-inflammatory, anti-nociceptive, antivirus activities. However, antitumor efficacy SC underlying mechanisms have not been completely delineated. In present study, inhibitory...