A5100328698- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Seaweed-derived Bioactive Compounds
- Prostate Cancer Treatment and Research
- Cancer-related molecular mechanisms research
- Lipid metabolism and disorders
- Pancreatic function and diabetes
- MicroRNA in disease regulation
- Metabolism, Diabetes, and Cancer
- Diabetes Management and Research
- Bone health and osteoporosis research
- Cancer, Lipids, and Metabolism
- Diet and metabolism studies
- Autoimmune and Inflammatory Disorders Research
- Diabetes and associated disorders
- Genetic Associations and Epidemiology
- Echinoderm biology and ecology
- Berberine and alkaloids research
- Alcohol Consumption and Health Effects
- Injury Epidemiology and Prevention
- Immune Cell Function and Interaction
- Nutrition and Health in Aging
- Prostate Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
Zhongshan Hospital
2016-2025
Fudan University
2016-2025
Central South University
2024-2025
Changsha Medical University
2025
Massachusetts General Hospital
2019-2025
Ocean University of China
2016-2025
Second Affiliated Hospital of Xi'an Jiaotong University
2023-2025
First Affiliated Hospital of Dalian Medical University
2023-2025
Dalian Medical University
1995-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
Phlorotannins are a group of complex polymers phloroglucinol (1,3,5-trihydroxybenzene), which unique compounds from marine brown algae. In our present study, procedure for extraction and enrichment phlorotannins
Objectives A randomized, parallel controlled, open-label clinical trial was conducted to evaluate the effect of a botanic compound berberine (BBR) on NAFLD. Methods in three medical centers (NIH Registration number: NCT00633282). total 184 eligible patients with NAFLD were enrolled and randomly received (i) lifestyle intervention (LSI), (ii) LSI plus pioglitazone (PGZ) 15mg qd, (iii) BBR 0.5g tid, respectively, for 16 weeks. Hepatic fat content (HFC), serum glucose lipid profiles, liver...
Abstract Visceral adipose dysfunction is a major cause of metabolic disorders. However, there lack clinical index for prediction visceral fat in Asians. The present study aims to establish adiposity evaluation health status Chinese, the largest Asian ethnic group. 485 subjects were recruited from Lianqian Community, Xiamen and received abdominal computed tomography(CT) area. A Chinese (CVAI) was created using multivariate linear regression analyses, further validated 6495 Changfeng Shanghai....
Nonalcoholic fatty liver disease (NAFLD) is characterized by accumulation of excessive triglycerides (TGs) in hepatocytes. Obesity a major risk factor for developing liver, although the intracellular molecular basis remains largely unclear. N6 -methyladenosine (m6 A) RNA methylation most common internal modification eukaryotic mRNA. In present study, m6 A sequencing and sequencing, we found that both enrichment mRNA expression lipogenic genes were significantly increased...
Increased dietary fat consumption is associated with colon cancer development. The exact mechanism by which induces not clear, however, increased bile acid excretion in response to high-fat diet may promote carcinogenesis. farnesoid X receptor (FXR) a member of the nuclear superfamily, and acids are endogenous ligands FXR. FXR highly expressed intestine liver where essential for maintaining homeostasis. role development known. current study evaluated effects deficiency mice on intestinal...
The incidence of prostate cancer (PCa) within Asian population used to be much lower than in the Western population; however, recent years and mortality rate PCa some countries have grown rapidly. This collaborative report summarized latest epidemiology information, risk factors, racial differences diagnosis, current status new trends surgery management novel agents for castration-resistant cancer. We believe such information would helpful clinical decision making urologists oncologists,...
High-calorie food leads to nonalcoholic fatty liver disease (NAFLD) through dysregulation of genes involved in lipid metabolism, but the precise mechanism remains unclear. DNA methylation represents one mechanisms that contributes gene expression via interaction with environmental factors. Berberine can alleviate db/db and ob/ob mice. Here, we investigated whether is pathogenesis NAFLD induced by a high-fat diet (HFD) berberine improves influencing status promoters key genes. HFD markedly...
Glucose transporter 1 (GLUT1) plays a critical role in tumorigenesis and tumor progression multiple cancer types. However, the specific function clinical significance of GLUT1 prostate (PCa) are still unclear. Therefore, this study, we investigated PCa.GLUT1 protein levels tissue tumor-adjacent normal tissues were measured compared. Furthermore, real-time PCR Western blot analysis both used to detect expression different PCa cell lines. Flow cytometry cell-based assays, such as glucose...
Accurate measures of liver fat content are essential for investigating the role hepatic steatosis in pathophysiology multiple metabolic disorders. No traditional imaging methods can accurately quantify content. [ 1 H]‐magnetic resonance spectroscopy (MRS) is restricted large‐scale studies because practical and technological issues. Previous attempts on computer‐aided ultrasound quantification varied method, quantitative parameters measured from different machines were hardly comparable. We...
Berberine, a compound from rhizome coptidis, is traditionally used to treat gastrointestinal infections, such as bacterial diarrhoea. Recently, berberine was shown have hypoglycaemic and hypolipidaemic effects. We investigated the mechanisms by which regulates hepatic lipid metabolism energy expenditure in mice.Liver-specific SIRT1 knockout mice their wild-type littermates were fed high-fat, high-sucrose (HFHS) diet treated with i.p. injection for five weeks. Mouse primary hepatocytes human...
The endoplasmic reticulum quality control protein activating transcription factor 6 (ATF6) has emerged as a novel metabolic regulator. Here, we show that adenovirus-mediated overexpression of the dominant-negative form ATF6 (dnATF6) increases susceptibility to develop hepatic steatosis in diet-induced insulin-resistant mice and fasted mice. Overexpression dnATF6 or small interfering RNA-mediated knockdown decreases transcriptional activity peroxisome proliferator-activated receptor α...
Nonalcoholic fatty liver disease (NAFLD) is a common disorder that currently lacks effective treatment. Berberine (BBR), botanic compound isolated from traditional Chinese medicine, exhibits potent therapeutic potential for the metabolic disease. The current study aimed to understand mechanisms underlying effect of BBR in NAFLD. We performed systematical analyses on hepatic expression profiles mRNAs and long noncoding RNAs (lncRNAs) high-fat diet (HFD)-induced steatotic animal model with or...
Brown adipose tissue (BAT) dissipates metabolic energy and mediates non-shivering thermogenesis, thereby boosting expenditure. Increasing BAT mass activity is expected to be a promising strategy for combating obesity; however, few medications effectively safely recruit activate in humans. Berberine (BBR), natural compound, commonly used as nonprescription drug treat diarrhea. Here, we reported that 1-month BBR intervention increased activity, reduced body weight, improved insulin sensitivity...