A5100450174- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Lung Cancer Diagnosis and Treatment
- MicroRNA in disease regulation
- RNA modifications and cancer
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
- Cancer Mechanisms and Therapy
- Radiomics and Machine Learning in Medical Imaging
- Metastasis and carcinoma case studies
- Colorectal Cancer Treatments and Studies
- Lymphoma Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Cancer Research and Treatments
- Epigenetics and DNA Methylation
- Sarcoma Diagnosis and Treatment
- Spine and Intervertebral Disc Pathology
- Medical Imaging and Pathology Studies
Tianjin Medical University General Hospital
2016-2025
Dalian Medical University
2003-2025
Second Affiliated Hospital of Dalian Medical University
2017-2025
Army Medical University
2003-2025
Central South University
2012-2025
Qilu Hospital of Shandong University
2006-2025
Shihezi University
2020-2025
Shanghai Jiao Tong University
2009-2025
Sun Yat-sen University
2009-2025
Chengdu University
2025
This Report has a number of inter-related general purposes. One is to explore the extent which food, nutrition, physical activity, and body composition modify risk cancer, specify factors are most important. To that environmental such as activity influence it preventable disease. The specifies recommendations based on solid evidence which, when followed, will be expected reduce incidence cancer.
The National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines for various malignant tumors have been widely recognized and followed by global oncologists, in order to promote the standardization of cancer treatment provide best recommendations patients. However, there are still some differences different countries areas based on specific conditions. In this paper, we compared between NCCN non-small-cell lung (Chinese version), original edition, European Society Medical...
Importance Programmed cell death ligand 1 inhibitors combined with chemotherapy has changed the approach to first-line treatment in patients extensive-stage small lung cancer (SCLC). It remained unknown whether adding a programmed (PD-1) inhibitor provided similar or better benefits SCLC, which would add evidence on efficacy of checkpoint SCLC. Objective To evaluate and adverse event profile PD-1 serplulimab plus compared placebo as Design, Setting, Participants This international,...
Abstract Identifying locoregional gastric cancer patients who are at high risk for relapse after resection could facilitate early intervention. By detecting molecular residual disease (MRD), circulating tumor DNA (ctDNA) has been shown to predict post-operative in several cancers. Here, we aim evaluate MRD detection by ctDNA and its association with clinical outcome resected cancer. This prospective cohort study enrolled 46 stage I–III that underwent curative intent. Sixty samples 296 plasma...
Importance Adjuvant and neoadjuvant immunotherapy have improved clinical outcomes for patients with early-stage non–small cell lung cancer (NSCLC). However, the optimal combination of checkpoint inhibition chemotherapy remains unknown. Objective To determine whether toripalimab in platinum-based will improve event-free survival major pathological response stage II or III resectable NSCLC compared alone. Design, Setting, Participants This randomized trial enrolled (without EGFR ALK...
Toxic epidermal necrolysis (TEN) is a rare and serious skin reaction. This study reports case of patient with lung adenocarcinoma (LUAD) who developed severe TEN after 8 days treatment Camrelizumab monotherapy. The patient’s condition was effectively relieved high-dose corticosteroids intravenous immunoglobulin therapy. diagnosis immune-related are challenging. associated the use Camrelizumab. Additionally, we provide an in-depth understanding TEN, summarizing its characteristics progress...
Chromatin accessibility plays a crucial role in mediating transcriptional dysregulation and heterogeneity Esophageal Squamous Cell Carcinoma (ESCC). Examining the chromatin of ESCC at single-cell level is imperative to understand how it activates oncogenes contributes onset metastasis ESCC. We performed assay for transposase-accessible sequencing (scATAC-seq) on cancerous adjacent noncancerous tissues from four patients who were pathological staged as T1a, T2b, T3b, or T4a, investigate...
<b>PURPOSE</b> The presence of age-related pulmonary crackles (rales) might interfere with a physician’s clinical management patients suspected heart failure. We examined the characteristics among stage A cardiovascular disease (American College Cardiology/American Heart Association failure staging criteria), stratiffed by decade, because little is known about these issues in such at high risk for congestive who have no structural or acute symptoms. <b>METHODS</b> After exclusion comorbid...
Survivin, a member of the inhibitor apoptosis protein (IAP) family, is detected in most common human cancers but not adjacent normal cells. Previous studies suggest that survivin associates with mitotic spindle and directly inhibits caspase activity. To further investigate function survivin, we used antisense (AS) oligonucleotide to downregulate expression cancer We found inhibition increased polyploidy while decreasing colony formation soft agar. Immunohistochemistry showed cells without...
The proto-oncogenes bcl-2 and bcl-x-long have been shown to suppress apoptotic cell death in a variety of vitro systems lines, including neurons. An alternatively spliced form bcl-x, bcl-x-short, is promoter death. Whether these genes are induced after ischemia or play any role determining the fate ischemic neurons unknown. To begin address this issue, we studied expression bcl-2, bcl-x mRNA protein global rat. Ischemia was isoflurane-anesthetized rats by four-vessel occlusion method....
Intraoperative and transdermal ultrasonography-mediated brachytherapy has been proved to be effective in postponing the development of abdominal carcinomas. The main purpose this study was evaluate clinical efficacy safety endoscopic ultrasonography (EUS)-guided interstitial implantation radioactive iodine 125 seeds advanced pancreatic cancer.In total, 22 patients with cancer positive fine-needle aspiration results underwent EUS-guided seeds. All enrolled received routine gemcitabine-based...
Cancer is a disease of complex genetic alterations, and comprehensive diagnosis beneficial to match each patient appropriate therapy. However, acquisition representative tumor samples invasive sometimes impossible. Circulating DNA (ctDNA) promising tool use as non-invasive biomarker for cancer mutation profiling. Here we implemented targeted next generation sequencing (NGS) with customized gene panel 382 cancer-relevant genes on 605 ctDNA in multiple types. Overall, tumor-specific mutations...
The epithelial-mesenchymal transition (EMT) and angiogenesis have emerged as two pivotal events in cancer progression. Curcumin has been extensively studied preclinical models clinical trials of prevention due to its favorable toxicity profile. However, the possible involvement curcumin EMT lung remains unclear. This study found that inhibited hepatocyte growth factor (HGF)-induced migration EMT-related morphological changes A549 PC-9 cells. Moreover, pretreatment with blocked HGF-induced...
Abstract Objective Interleukin‐1 receptor antagonist (IL‐1Ra) has been evaluated for the intraarticular treatment of osteoarthritis. Such administration proteins may have limited utility because their rapid clearance and short half‐life in joint. The fusion a drug to elastin‐like polypeptides (ELPs) promotes formation aggregating particles that form “drug depot” at physiologic temperatures, phenomenon intended prolong presence drug. purpose this study was develop an injectable depot composed...
The purposes of this study were to investigate the potential roles long noncoding RNA (lncRNA) PVT1 in thyroid cancer cell proliferation and explore their possible mechanisms. A total 84 patients who diagnosed as having (papillary carcinoma (PTC), follicular (FTC), anaplastic (ATC)) Renji Hospital enrolled study. Expressions lncRNA tissues lines (IHH-4, FTC-133, 8505C) analyzed using RT-polymerase chain reaction (PCR) western blotting analysis. effects expression on cycle flow cytometry....
Glucose transporter 1 (GLUT1) plays a critical role in tumorigenesis and tumor progression multiple cancer types. However, the specific function clinical significance of GLUT1 prostate (PCa) are still unclear. Therefore, this study, we investigated PCa.GLUT1 protein levels tissue tumor-adjacent normal tissues were measured compared. Furthermore, real-time PCR Western blot analysis both used to detect expression different PCa cell lines. Flow cytometry cell-based assays, such as glucose...