A5044168155- Lung Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Esophageal and GI Pathology
- Plant Molecular Biology Research
- Research in Cotton Cultivation
- Gastric Cancer Management and Outcomes
- Plant Gene Expression Analysis
- Esophageal Cancer Research and Treatment
- Tracheal and airway disorders
- interferon and immune responses
- Metastasis and carcinoma case studies
- RNA regulation and disease
- Photosynthetic Processes and Mechanisms
- Gastrointestinal Tumor Research and Treatment
- Plant-Microbe Interactions and Immunity
- RNA modifications and cancer
- MicroRNA in disease regulation
- Plant Pathogens and Fungal Diseases
- Colorectal Cancer Treatments and Studies
- Bacterial Genetics and Biotechnology
- Chromosomal and Genetic Variations
- Genomics and Phylogenetic Studies
- Cancer Immunotherapy and Biomarkers
- Plant Reproductive Biology
Zhejiang Sci-Tech University
2019-2025
Second Affiliated Hospital of Nanchang University
2016-2025
Chinese PLA General Hospital
2000-2025
Nanchang University
2016-2025
Vision Technology (United States)
2024
Weatherford College
2023
Guangxi University
2023
Changchun University of Science and Technology
2022
Zero to Three
2021
Hangzhou Normal University
2010-2019
Importance Adjuvant and neoadjuvant immunotherapy have improved clinical outcomes for patients with early-stage non–small cell lung cancer (NSCLC). However, the optimal combination of checkpoint inhibition chemotherapy remains unknown. Objective To determine whether toripalimab in platinum-based will improve event-free survival major pathological response stage II or III resectable NSCLC compared alone. Design, Setting, Participants This randomized trial enrolled (without EGFR ALK...
425126 Background: Adjuvant and neoadjuvant immunotherapy have been approved by US FDA to treat early-stage NSCLC. However, the optimal adjuvant treatment, including duration of are unknown. We present interim results a randomized, double-blind, placebo-controlled, phase III trial evaluate efficacy safety perioperative toripalimab plus chemotherapy followed maintenance vs in resectable stage Methods: Patients with II/III NSCLC, without EGFR/ALK alterations for non-squamous were randomly...
The Klebsiella pneumoniae multidrug resistance plasmid pKP048 was completely sequenced. This carries several important determinants, such as bla(KPC-2), bla(DHA-1), qnrB4, and armA, which confer to carbapenems, cephalosporins, fluoroquinolones, aminoglycosides, respectively. Analysis of the finished 151,188-bp sequence data revealed 163 putative genes, 108 were assigned functions replication, stable inheritance, antibiotic resistance, a mobile element, conjugal transfer,...
ABSTRACT We previously reported that the multidrug-resistant (MDR) Acinetobacter baumannii strain MDR-ZJ06, belonging to European clone II, was widely spread in China. In this study, we report whole-genome sequence of clinically important strain. A 38.6-kb AbaR-type genomic resistance island (AbaR22) identified MDR-ZJ06. AbaR22 has a structure similar those islands found A. strains AYE and AB0057, but it contained only few antibiotic genes. The region resistant gene accumulation as described...
The importance of long non-coding RNAs (lncRNAs) in plant development has been established, but a systematic analysis lncRNAs expressed during pollen and fertilization elusive. We performed time series RNA-seq experiments at five developmental stages three different points after pollination Brassica rapa identified 12 051 putative lncRNAs. A comprehensive view dynamic lncRNA expression networks underpinning was provided. B. share many common characteristics lncRNAs: relatively short length,...
8501 Background: Adjuvant and neoadjuvant immunotherapy have been approved by US FDA to treat early-stage NSCLC. However, the optimal adjuvant treatment, including duration of are unknown. We present interim results a randomized, double-blind, placebo-controlled, Phase III trial evaluate efficacy safety perioperative toripalimab plus chemotherapy followed maintenance vs in resectable stage Methods: Patients with II/III NSCLC, without EGFR/ALK alterations for non-squamous were randomized 1:1...
Background Methods such as the number of positive lymph nodes (nPLN), node ratio (LNR), and log odds (LODDS) are used to predict prognosis in patients with non-small cell lung cancer (NSCLC). We hypothesized that LODDS could be a superior independent predictor aimed compare its effectiveness nPLN LNR predicting survival outcomes stage I-IIIA NSCLC patients. utilized data from Surveillance, Epidemiology, End Results (SEER) 17 registry (2010–2019) study patients, focusing on those who...
ABSTRACT Lactobacillus casei Zhang is a new probiotic bacterium isolated from koumiss collected in Inner Mongolia, China. Here, we report the main genome features of L. and identification several predicted proteins implicated interactions with host.
<i>Lactobacillus casei</i> Zhang, isolated from traditional home-made koumiss in Inner Mongolia of China, was considered as a new probiotic bacterium by selection tests. We carried out proteomics study to identify and characterize proteins expressed <i>L. Zhang the exponential phase stationary phase. Cytosolic strain cultivated de Man, Rogosa, Sharpe broth were resolved two-dimensional gel electrophoresis using pH 4–7 linear gradients. The number protein spots quantified gels 487 ± 21...
Abstract The tangerine pathotype of Alternaria alternata produces the A . citri toxin (ACT) and is causal agent citrus brown spot that results in significant yield losses worldwide. Both production ACT ability to detoxify reactive oxygen species (ROS) are required for pathogenicity citrus. In this study, we report 34.41 Mb genome sequence strain Z7 host selective gene cluster was identified, which included 25 genes with 19 them not reported previously. Of these, 10 were present only...
Abstract Dendrobium officinale is an important traditional Chinese herb. Here, we did a transcriptome-wide, organ-specific study on this valuable plant by combining RNA, small RNA (sRNA) and degradome sequencing. sequencing of four organs (flower, root, leaf stem) enabled us to obtain 536,558 assembled transcripts, from which 2,645, 256, 42 54 were identified be highly expressed in the respectively. Based sRNA sequencing, 2,038, 2, 21 24 sRNAs specifically accumulated A total 1,047 mature...
Cotton Verticillium wilt, caused by the notorious fungal phytopathogen dahliae (V. dahliae), is a destructive soil-borne vascular disease and severely decreases cotton yield quality worldwide. Transcriptional post-transcriptional regulation of genes responsive to V. are crucial for tolerance in plants. However, specific microRNAs (miRNAs) miRNA/target gene crosstalk involved resistance wilt remain largely limited. To investigate roles regulatory RNAs under induction upland cotton, mRNA small...
Summary Naturally coloured cotton (NCC) fibres need little or no dyeing process in textile industry to low‐carbon emission and are environment‐friendly. Proanthocyanidins (PAs) their derivatives were considered as the main components causing fibre coloration made NCCs very popular healthy, but monotonous colours greatly limit wide application of NCCs. Here a G. hirsutum empurpled mutant ( HS2 ) caused by T‐DNA insertion is found enhance anthocyanidins biosynthesis accumulate whole plant....
Penicillium digitatum, causing citrus green mold, is one of the most devastating pathogenic fungi for postharvest fruits. The disease control becoming less efficient because dispersal fungicide-resistant strains. However, genome-scale analyses its resistance mechanism are scarce. In this work, we sequenced whole genome R1 genotype strain Pd01-ZJU and investigated genes DNA elements highly associated with drug resistance. Variation in related to between P. digitatum strains was revealed both...
Abstract Nat-siRNAs (small interfering RNAs originated from natural antisense transcripts) are a class of functional small RNA (sRNA) species discovered in both plants and animals. These siRNAs highly enriched within the annealed regions NAT (natural transcript) pairs. To date, great research efforts have been taken for systematical identification NATs various organisms. However, developing freely available easy-to-use program prediction is strongly demanded by researchers. Here, we proposed...