A5018376164- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Esophageal Cancer Research and Treatment
- Circular RNAs in diseases
- Esophageal and GI Pathology
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Anesthesia and Sedative Agents
- Occupational and environmental lung diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Metastasis and carcinoma case studies
- Anesthesia and Pain Management
- Bone and Dental Protein Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Curcumin's Biomedical Applications
- Scoliosis diagnosis and treatment
- Epigenetics and DNA Methylation
- Spinal Fractures and Fixation Techniques
- Gastroesophageal reflux and treatments
- Dysphagia Assessment and Management
- Medical Imaging and Analysis
- Hedgehog Signaling Pathway Studies
Henan Cancer Hospital
2017-2025
Zhengzhou University
2017-2025
425126 Background: Adjuvant and neoadjuvant immunotherapy have been approved by US FDA to treat early-stage NSCLC. However, the optimal adjuvant treatment, including duration of are unknown. We present interim results a randomized, double-blind, placebo-controlled, phase III trial evaluate efficacy safety perioperative toripalimab plus chemotherapy followed maintenance vs in resectable stage Methods: Patients with II/III NSCLC, without EGFR/ALK alterations for non-squamous were randomly...
8501 Background: Adjuvant and neoadjuvant immunotherapy have been approved by US FDA to treat early-stage NSCLC. However, the optimal adjuvant treatment, including duration of are unknown. We present interim results a randomized, double-blind, placebo-controlled, Phase III trial evaluate efficacy safety perioperative toripalimab plus chemotherapy followed maintenance vs in resectable stage Methods: Patients with II/III NSCLC, without EGFR/ALK alterations for non-squamous were randomized 1:1...
Circular RNA (circRNA) plays an important role in cancer progression. Here, we investigated the function of circ_0086414 malignant progression esophageal (EC). expression circ_0086414, microRNA-1290 (miR-1290), and SPARC like 1 (SPARCL1) was detected by quantitative real-time polymerase chain reaction. The protein levels N-cadherin, E-cadherin, SPARCL1 were checked Western blotting analysis. Cell proliferation 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT),...
Objective: To investigate the efficacy and safety of sugammadex for antagonistic neuromuscular block in patients with radical resection lung cancer under thoracoscope. Methods: One hundred undergoing thoracoscope Affiliated Cancer Hospital Zhengzhou University from March to September 2019, were randomly divided into control group (group C) S). All anaesthetized (induced maintained) intravenous target-controlled infusion propofol remifentanil, intermittent injection rocuronium. During...
Background: Various reports showed some conflicting data on survival at different ages. This study aimed to investigate the main cause of death in older patients with lung cancer and perform a comparison younger order observe differences between these two cohorts. Methods: Outcomes stage IA non-small cell (NSCLC) ≤3 cm who underwent lobectomy without induction therapy Surveillance, Epidemiology, End Results-18 (SEER-18; January 2004 December 2016) database were evaluated using multivariable...
Abstract Introduction Difference of the short diameter lymph nodes in main regions esophageal squamous cell carcinoma (ESCC) and its value diagnosis need to explore. Methods The clinical data patients with thoracic ESCC who underwent surgical treatment our hospital were collected. diameters largest node each region patient measured by preoperative enhanced computed tomography (CT) compared postoperative pathology. Results A total 477 did not receive neoadjuvant therapy enrolled this study....
Abstract Lung cancer remains the leading cause of deaths worldwide. Although low-dose spiral computed tomography (LDCT) screening is used for detection lung in a high-risk population, false-positive results LDCT remain clinical problem. Here, we developed blood test novel three gene methylation panel and validated diagnostic efficiency from total 351 subjects (197 controls, 154 cases). DNA short stature homeobox 2 ( SHOX2 ), ras association domain family 1A RASSF1A prostaglandin E receptor 4...
Objective To systemic evaluate postoperative pulmonary function between segmentectomy and lobectomy in patients with early stage non-small cell lung cancer. Methods Computer searched was performed up to September 2016 at the Cochrane Library, PubMed, EMBASE, CBM, CNKI , VIP Wanfang database, collected Patients Non-Small Cell Lung Cancer. Study selection, data collection critical assessment of included studies were according recommendations Collaboration. Results Eight 308 386...
Abstract Background Lung cancer remains the leading cause of deaths across world. Early detection lung by low-dose computed tomography (LDCT) can reduce mortality rate. However, making a definitive preoperative diagnosis malignant pulmonary nodules (PNs) found LDCT is clinical challenge. This study aimed to develop prediction model based on DNA methylation biomarkers and radiological characteristics for identifying from benign PNs. Methods We assessed three ( PTGER4 , RASSF1A, SHOX2 ) in...
Abstract Neoadjuvant therapy follow by surgery is the standard treatment mode for patients with locally advanced esophageal squamous cell carcinoma (ESCC). This research aimed to investigated potential of sonic hedgehog (Shh), glioma-associated oncogene homolog1 (Gli1) and Phospho-S6 (p-S6) predict response ESCC neoadjuvant chemotherapy. Firstly, expressions Shh, Gli1 p-S6 in cancer tissues normal 49 without were detected immunohistochemistry. A total 390 included nest study, 44 pairs or...
Abstract Purpose: This retrospective study evaluated the impact of nasogastric decompression (NGD) on gastric tube size to optimize Enhanced Recovery After Surgery protocol after McKeown minimally invasive esophagectomy (MIE). Methods: Overall, 640 patients were divided into two groups according (NGT) placement intraoperatively. Using propensity score matching, 203 pairs individuals identified for comparisons postoperative days (PODs) 1 and 5. Results: Gastric tubes larger in non-NGD group...