A5007084753- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Tracheal and airway disorders
- Pleural and Pulmonary Diseases
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
- Salivary Gland Tumors Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Metastasis and carcinoma case studies
- Congenital Diaphragmatic Hernia Studies
- Gastric Cancer Management and Outcomes
- Trauma Management and Diagnosis
- Lung Cancer Research Studies
- Cancer Diagnosis and Treatment
- Esophageal and GI Pathology
- Head and Neck Cancer Studies
- Cardiac tumors and thrombi
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Esophageal Cancer Research and Treatment
- Cancer Cells and Metastasis
- Voice and Speech Disorders
- Myasthenia Gravis and Thymoma
- COVID-19 Clinical Research Studies
Sichuan University
2016-2025
West China Hospital of Sichuan University
2016-2025
Southwest Medical University
2025
Barro Colorado Island
2024
Soochow University
2023
West China Medical Center of Sichuan University
2023
State Key Laboratory of Oral Diseases
2020
Science and Technology Department of Sichuan Province
2020
South China Institute of Collaborative Innovation
2016-2019
Tulane University
2015-2016
Abstract Purpose: We assessed whether perioperative circulating tumor DNA (ctDNA) could be a biomarker for early detection of molecular residual disease (MRD) and prediction postoperative relapse in resected non–small cell lung cancer (NSCLC). Experimental Design: Based on our prospective, multicenter cohort dynamic monitoring ctDNA surgery patients (LUNGCA), we enrolled 950 plasma samples obtained at three time points (before surgery, 3 days 1 month after surgery) 330 stage I–III NSCLC...
Importance Adjuvant and neoadjuvant immunotherapy have improved clinical outcomes for patients with early-stage non–small cell lung cancer (NSCLC). However, the optimal combination of checkpoint inhibition chemotherapy remains unknown. Objective To determine whether toripalimab in platinum-based will improve event-free survival major pathological response stage II or III resectable NSCLC compared alone. Design, Setting, Participants This randomized trial enrolled (without EGFR ALK...
425126 Background: Adjuvant and neoadjuvant immunotherapy have been approved by US FDA to treat early-stage NSCLC. However, the optimal adjuvant treatment, including duration of are unknown. We present interim results a randomized, double-blind, placebo-controlled, phase III trial evaluate efficacy safety perioperative toripalimab plus chemotherapy followed maintenance vs in resectable stage Methods: Patients with II/III NSCLC, without EGFR/ALK alterations for non-squamous were randomly...
It is important to develop a surgical technique reduce dissemination of tumor cells into the blood during surgery.To compare outcomes different sequences vessel ligation surgery on and survival in patients with non-small cell lung cancer.This multicenter, randomized clinical trial was conducted from December 2016 March 2018 cancer who received thoracoscopic lobectomy West China Hospital, Daping Sichuan Cancer Hospital. To further 2 procedures, we reviewed Western Lung database (2005-2017)...
8501 Background: Adjuvant and neoadjuvant immunotherapy have been approved by US FDA to treat early-stage NSCLC. However, the optimal adjuvant treatment, including duration of are unknown. We present interim results a randomized, double-blind, placebo-controlled, Phase III trial evaluate efficacy safety perioperative toripalimab plus chemotherapy followed maintenance vs in resectable stage Methods: Patients with II/III NSCLC, without EGFR/ALK alterations for non-squamous were randomized 1:1...
Primary mediastinal liposarcomas (PLMs) are extremely rare. Patients typically present with symptoms caused by tumor size, as the mass can compress surrounding tissues and organs. Here, we report a case of large primary liposarcoma that was successfully resected thoracoscopically. By reviewing available literature on sharing perioperative insights, aim to provide guidance diagnosis surgical management liposarcomas. A 38-year-old male presented our hospital complaints dysphagia after meals....
Endometrial cancer (EC) is the most frequent gynecological malignancy and a major cause of morbidity mortality for women worldwide. Programmed cell death protein 1 (PD‑1) its ligands programmed ligand (PD‑L1) 2 (PD‑L2) have been well studied in lung cancer, melanoma renal‑cell cancer. However, few studies performed EC. The purpose present study was to assess expression PD‑1, PD‑L1 PD‑L2 35 human normal endometrial tissue samples 75 EC using immunohistochemical staining. It found that 61.3%...
<h3>Objective</h3> Estrogen is a well-known oncogenic driver in endometrial (ECs) and breast cancers (BCs). Programmed cell death protein 1 (PD-1) its ligands PD-1 Ligand (PD-L1) PD-L2 have been shown to mediate immune evasion of the tumor cells. The purpose present study was assess effects estrogen on PD-L1 expression EC BC lines. <h3>Methods</h3> 17β-Estradiol (E2)–induced possible signaling pathway were investigated Coculture T cells cancer with E2 stimulation performed functions...
Video-assisted thoracic surgery (VATS) has been considered as the better choice for surgical treatment of resectable non-small cell lung cancer (NSCLC). This study aimed to evaluate short- and long-term outcomes VATS versus open thoracotomy lobectomy patients with pathological stage (p-stage) I-II NSCLC in one high-volume center China.Perioperative survival who underwent lobectomies p-stage from May 2006 June 2013 Western China Lung Cancer Database (WCLCD) were studied using propensity score...
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a chronic fibrotic interstitial lung disease characterized by progressive dyspnea and decreased function, yet its exact etiology remains unclear. It of great significance to discover new drug targets for IPF. Methods We obtained the cis-expression quantitative trait locus (cis-eQTL) druggable genes from eQTLGen Consortium as exposure genome wide association study (GWAS) IPF International Genetics outcomes simulate effects drugs on...
Massive bleeding caused by vascular injury is considered the most troublesome and dangerous complication during video-assisted thoracoscopic surgery (VATS) pulmonary resection an important reason for emergency conversion to thoracotomy. The purpose of this paper was show suction-compressing angiorrhaphy technique (SCAT) troubleshooting problem without conversion.A total 414 consecutive VATS anatomic resections were performed between May 2006 July 2011, among which 17 operations (4.11 %)...
<h2>Abstract</h2><h3>Objective</h3> Thoracoscopic anatomic single or combined basal segmentectomy is technically challenging because of the variation and deep location vessels bronchi in parenchyma. This study aimed to describe thoracoscopic segments using a single-direction method. <h3>Methods</h3> retrospective included 137 patients who underwent between April 2015 August 2019. All procedures were performed via preferred inferior pulmonary ligament approach an interlobar fissure following...
Background: Prolonged air leak (PAL) is one of the most common postoperative complications after pulmonary resection. The aim this study was to reveal incidence and risk factors PAL in video-assisted thoracic surgery (VATS) lung cancer resection, evaluate effect on complications, length stay (PLOS), medical costs. Methods: Continuous patients who underwent VATS major resection for between January 2014 December 2015 were studied. Clinical data these obtained from Western China Lung Cancer...
With an increasing amount of small nodules being detected, segmentectomy has recently received a great deal attention. We have previously reported the feasibility and safety uniportal segmentectomy. This study aims to further compare perioperative oncological outcomes three-port thoracoscopic in lung cancer patients.Patients undergoing for from January 2014 March 2021 were enrolled. Clinical data collected Western China Lung Cancer Database, prospectively maintained database at Department...
<h2>Summary</h2> Lung adenocarcinoma is a type of cancer that exhibits wide range clinical radiological manifestations, from ground-glass opacity (GGO) to pure solid nodules, which vary greatly in terms their biological characteristics. Our current understanding this heterogeneity limited. To address gap, we analyze 58 lung patients via machine learning, single-cell RNA sequencing (scRNA-seq), and whole-exome sequencing, identify six multicellular ecotypes (LMEs) correlating with distinct...
The International Association of Diabetes and Pregnancy Study Groups (IADPSG) proposed that a one-time value fasting plasma glucose 5.1 mmol/l or over at any time the pregnancy is sufficient to diagnose gestational diabetes. We evaluated repercussions application this threshold in pregnant Han Chinese women.This retrospective study 5360 (72.3% total) consecutively recruited women one centre from 2008 2011. These underwent two-step diabetes diagnostic protocol according previous American...
Abstract: Tumor-associated macrophages play an important role in tumor growth and progression. These are heterogeneous with diverse functions, eg, M1 inhibit growth, whereas M2 promote growth. In this study, we found that IFNγ and/or celecoxib (cyclooxygenase-2 inhibitor) treatment consistently inhibited a mouse lung cancer model. alone increased the percentage of but decreased tumors, thus M2/M1 macrophage ratio was reduced to 1.1 1.7 by alone, respectively, compared 4.4 control group. A...
We present our preliminary experience of thoracoscopic bronchovascular double sleeve lobectomy (SL) for non-small-cell lung cancer in the upper lobe involving both bronchus and pulmonary artery. From May 2012 to July 2013, 4 patients were selected this operation, including 3 cases left 1 case right lobectomy. Surgical procedures performed with four ports first patient three other patients. Systemic lymph node dissection was finished before removal diseased lobe. Thoracoscopic reconstruction...