A5102018254- Immune Response and Inflammation
- Cancer-related molecular mechanisms research
- Algal biology and biofuel production
- NF-κB Signaling Pathways
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Antioxidant Activity and Oxidative Stress
- Retinal Imaging and Analysis
- MicroRNA in disease regulation
- RNA modifications and cancer
- Corneal surgery and disorders
- Extracellular vesicles in disease
- Immunotherapy and Immune Responses
- Ophthalmology and Visual Impairment Studies
- Corneal Surgery and Treatments
- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- Influenza Virus Research Studies
- Animal Disease Management and Epidemiology
- Cancer, Lipids, and Metabolism
- Cancer Cells and Metastasis
- Bacterial Genetics and Biotechnology
- Ferroptosis and cancer prognosis
- Hemispheric Asymmetry in Neuroscience
- Sirtuins and Resveratrol in Medicine
Shandong University
2015-2025
Ludong University
2024-2025
Guangzhou Medical University
2024-2025
Shandong First Medical University
2025
State Key Laboratory of Respiratory Disease
2024-2025
Nanjing University of Chinese Medicine
2025
University of Chinese Academy of Sciences
2024
Jinan University
2016-2024
Shanghai Institute of Nutrition and Health
2024
Chinese University of Hong Kong
2018-2024
Chromatin accessibility plays a crucial role in mediating transcriptional dysregulation and heterogeneity Esophageal Squamous Cell Carcinoma (ESCC). Examining the chromatin of ESCC at single-cell level is imperative to understand how it activates oncogenes contributes onset metastasis ESCC. We performed assay for transposase-accessible sequencing (scATAC-seq) on cancerous adjacent noncancerous tissues from four patients who were pathological staged as T1a, T2b, T3b, or T4a, investigate...
The latent infection by herpes virus type 1 (HSV-1) may be lifelong in trigeminal ganglia and a suspected cause of Alzheimer's Disease (AD) Amyotrophic lateral sclerosis (ALS). Whether how N6-methyladenosine (m6A) modification viral RNAs affects are poorly understood. Here, we report that HSV-1 enhanced the expression m6A writers (METTL3, METTL14) readers (YTHDF1/2/3) at early stage decreased their later on, while suppressed erasers' (FTO, ALBKH5) immediately upon to facilitate replication....
ABSTRACT Metastasis remains a leading cause of cancer‐related deaths, defined by complex, multi‐step process in which tumor cells spread and form secondary growths distant tissues. Despite substantial progress understanding metastasis, the molecular mechanisms driving this development effective therapies remain incompletely understood. Elucidating pathways governing metastasis is essential for discovery innovative therapeutic targets. The rapid advancements sequencing technologies expansion...
To assess the accuracy of Plusoptix A09 photoscreener in detecting amblyopia risk factors children and determine referral criteria when using for a large-scale vision screening.Pediatric patients attending our eye clinic underwent comprehensive ophthalmic examination that included photorefraction, orthoptic examination, anterior segment assessment, fundus cycloplegic retinoscopy. The measurements were collected statistical analyses.One hundred seventy-eight (mean age ± SD: 6.2±2.4 years,...
An understanding of the interaction between antibody and its targeted antigen knowing epitopes are critical for development monoclonal drugs. Complement factor H (CFH) is implied to play a role in tumor growth metastasis. autoantibody CHF associated with anti-tumor cell activity. The human Ab42 that was isolated from cancer patient CFH polypeptide (pCFH) analyzed by molecular docking, dynamics (MD) simulation, free energy calculation, computational alanine scanning (CAS). Experimental (EAS)...
Purpose: To evaluate the therapeutic efficacy of conbercept for treatment diabetic macular edema (DME) with different baseline visual acuity.Methods: This is a retrospective, comparative study. A total 107 eyes patients were included. According to levels best corrected acuity (BCVA) and regimen, DME divided into four groups: subgroup worse VA (less than 69 letters, Snellen equivalent, 20/50 or worse; n = 37), untreated VA(n 28); better (78 20/32 20/40; 25), (n 17). Patients received one...
Abstract Vascular endothelial growth factor (VEGF) and placental (PlGF) plays a crucial role in breakdown of the blood-retinal barrier due to hyperpermeability diabetic retinopathy (DR). However, distinct signaling driven by VEGF PlGF pathogenesis DR remains unclear. In this study, we investigated VEGF- PlGF- related pathways their roles cultured human microvascular retinal cells (hRECs) under high glucose conditions (HG; 25 mM). Apoptotic cell death was evaluated, FITC conjugated bovine...
<h2>Summary</h2> Polarized vesicle transport plays an important role in cell polarization, but the mechanisms underlying this process and its innate immune responses are not well understood. Here, we describe a phosphorylation-regulated polarization mechanism that is for neutrophil adhesion to endothelial cells during inflammatory responses. We show protein kinase PKN1 phosphorylates RPH3A, which enhances binding of RPH3A guanosine triphosphate (GTP)-bound RAB21. These interactions polarized...
Colorectal cancer (CRC) is one of the most common malignancies currently. Despite advances in drug development, survival and response rates CRC patients are still poor. In our previous study, a library comprised 1056 bioactive compounds was used for screening drugs that could suppress CRC. Lomerizine 2HCl, which an approved prophylactic migraines, selected studies. The results vitro vivo assays suggested lomerizine 2HCl suppresses cell growth promotes apoptosis cells. Moreover, inhibits...
Two marine microalgae, Nitzschia closterium and Isochrysis zhangjiangensis, treated for 9 days with photosynthetically active radiation (PAR), were subjected to 3 of ultraviolet light band A at 365 nm (UVA365) followed by a day post-UVA PAR treatment. Compared the control that only had treatment, UVA365 treatment significantly (p < 0.05) increased amounts total xanthophylls in N. I. zhangjiangensis up 3.53- 1.23-fold, respectively, after irradiation. In particular, markedly two major...
Abstract To develop an effective, safe, and convenient vaccine for the prevention of highly pathogenic avian influenza (HPAI) H5N1, we have constructed a recombinant Bacillus subtilis strain ( B.S.-HA ) expressing hemagglutinin (HA) protein. Then evaluated immune function in chicken bone marrow derived dendritic cells (BM-DCs), response after oral immunization. Our results show that could be sampled by BM-DCs vitro increase major histocompatibility complex (MHC) II phenotype. The weight,...
Background: Limited therapeutic options are available for advanced LUAD without driver gene mutations. Anti-CDK therapy has shown effectiveness in several kind of cancers, however, the mechanisms still need to be elucidated. Materials and Methods: The lncRNA associated with CDK1 immunomodulatory factors that regulate were found by bioinformatics analysis experimental verification. prognostic model immune resistance mechanism lung adenocarcinoma revealed single cell analysis, infiltration...
Four potent native human monoclonal antibodies (mAbs) targeting distinct epitopes on tetanus toxin (TeNT) are isolated with neutralization potency ranging from approximately 17 mg to 6 each that equivalent 250 IU of anti-TeNT immunoglobulin. TT0170 binds fragment B, and TT0069 TT0155 bind AB. mAb TT0067 C blocks the binding TeNT gangliosides. The co-crystal structure at a 2.0-Å resolution demonstrates directly occupies W pocket one receptor sites TeNT, resulting in blocking ganglioside...
Marine microorganisms such as phytoplanktons are a rich resource of bioactive components with antioxidant and anti-proliferative activities that can act novel functional food ingredients. In this study, the pigment profiles, total mycosporine-like amino acids (MAAs) phenolic contents (TPCs) in solvent extracts including 90% acetone methanol from five marine Nitzschia closterium (Bacillariophyta), Isochrysis zhangjiangensis (Haptophyta), Platymonas subcordiformis (Chlorophyta), Porphyridium...
Outbreaks of infectious diseases caused by viruses, such as pseudorabies (PR), foot-and-mouth disease (FMD), and PPR led to economic losses reaching billions dollars. Both PR FMD were eliminated in several countries via large-scale vaccination programs using DIVA-compatible vaccines, which lack the gE protein nonstructural proteins, respectively. However, there are still extensive challenges facing development deployment vaccines because they time-consuming full uncertainty. Further,...
Hepatocellular carcinoma (HCC) remains one of the leading causes cancer-related death and has a poor prognosis worldwide, thus, more effective drugs are urgently needed. In this article, small molecule drug library composed 1,056 approved medicines from FDA was used to screen for anticancer drugs. The tetracyclic compound maprotiline, highly selective noradrenergic reuptake blocker, strong antidepressant efficacy. However, effect maprotiline unclear. Here, we investigated potential in HCC...