A5100751823- Cardiovascular Function and Risk Factors
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Thyroid Disorders and Treatments
- Cardiac Imaging and Diagnostics
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac Arrhythmias and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Obstructive Sleep Apnea Research
- Congenital Heart Disease Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Cytomegalovirus and herpesvirus research
- Biomarkers in Disease Mechanisms
- Cardiac electrophysiology and arrhythmias
- Traditional Chinese Medicine Studies
- Neuroscience of respiration and sleep
- Thyroid Cancer Diagnosis and Treatment
- Cardiovascular Disease and Adiposity
- Atrial Fibrillation Management and Outcomes
- Neurological Complications and Syndromes
- Cell Adhesion Molecules Research
- Cardiac Structural Anomalies and Repair
- Alzheimer's disease research and treatments
- ECG Monitoring and Analysis
- Heart Rate Variability and Autonomic Control
Shanghai Sunshine Rehabilitation Center
2025
Capital Medical University
2015-2024
Shanghai Chest Hospital
2016-2024
Shanghai Jiao Tong University
2020-2024
Binzhou University
2024
Beijing Anzhen Hospital
2015-2024
Shenzhen University
2024
Yantaishan Hospital
2024
Binzhou Medical University
2024
Second Xiangya Hospital of Central South University
2009-2024
Malignant cells, like all actively growing must maintain their telomeres, but genetic mechanisms responsible for telomere maintenance in tumors have only recently been discovered. In particular, mutations of the binding proteins alpha thalassemia/mental retardation syndrome X-linked ( ATRX ) or death-domain associated protein DAXX shown to underlie a mechanism not involving telomerase (alternative lengthening telomeres), and point promoter reverse transcriptase TERT gene increase expression...
Abstract Background Patients with critical illness due to infection the 2019 coronavirus disease (COVID-19) show rapid progression acute respiratory failure. The study aimed screen most useful predictive factor for caused by COVID-19. Methods prospectively involved 61 patients COVID-19 as a derivation cohort, and 54 validation cohort. was selected using LASSO regression analysis. A nomogram based on non-specific laboratory indicators built predict probability of illness. Results...
Abstract Background Severe ill patients with 2019 novel coronavirus (2019-nCoV) infection progressed rapidly to acute respiratory failure. We aimed select the most useful prognostic factor for severe illness incidence. Methods The study prospectively included 61 2019-nCoV treated at Beijing Ditan Hospital from January 13, 2020 31, 2020. Prognostic of was selected by LASSO COX regression analyses, predict probability 2019-CoV pneumonia. predictive accuracy evaluated concordance index,...
Abstract Although Crohn’s disease has been traditionally considered to be Th1-mediated, the newly identified Th17 cells emerged recently as crucial participants. Th1/Th17 differentiation is controlled primarily by IL-12 family of cytokines secreted activated dendritic (DCs) and macrophages. IL-23 IL-12/IL-27 have opposite effects, supporting Th1 phenotypes, respectively. We found that PGE2, a major lipid mediator released in inflammatory conditions, shifts IL-12/IL-23 balance DCs favor...
Traditional drug development for Alzheimer's disease (AD) is costly, time consuming and burdened by a very low success rate. An alternative strategy repositioning, redirecting existing drugs another disease. The large amount of biological data accumulated to date warrants comprehensive investigation better understand AD pathogenesis facilitate the process anti-AD repositioning. Hence, we generated list protein targets analyzing most recent publically available 'omics' data, including...
Background and Objective MicroRNAs (miRNAs) have been shown to be associated with various physiological pathological conditions, including inflammation cardiovascular disease, but little is known about their relationship the presence of coronary artery disease (CAD) severity. Methods A total 195 consecutive subjects who underwent angiography for chest pain evaluation were enrolled in this study. In CAD patients severity lesions was assessed by number diseased vessels Synergy between PCI...
Abstract Objective The purpose of this study was to investigate the clinical value velocity vector imaging (VVI) in assessment normal fetal regional myocardial performance and establish a normative data set for Chinese fetuses. Methods One hundred fifty‐one healthy fetuses were divided into five groups according their gestational age. Digital dynamic four‐chamber views collected analyzed offline. tissue velocity, strain, strain rate interventricular septum left lateral wall measured systole...
Although Bone morphogenetic protein-2 (BMP-2) is a known mediator of bone regeneration and vascular calcification, to date no study has investigated the relationship between BMP-2 type 2 diabetes mellitus (T2DM) its possible role in coronary artery disease (CAD). The purpose this evaluate with atherosclerosis calcification patients T2DM. 124 subjects were enrolled study: 29 T2DM CAD; 26 without 36 CAD T2DMand 34 or (control group). Severity lesions was assessed using angiography...
The aim of this study was to investigate the association between hypothyroidism and major adverse cardiovascular cerebral events (MACCE) in patients undergoing percutaneous coronary intervention (PCI).Two thousand four hundred thirty who underwent PCI were included. Subjects divided into two groups: (n = 686) defined either as a history or thyroid-stimulating hormone (TSH) ≥5.0 mU/mL, euthyroidism 1744) no and/or 0.3 mU/mL ≤ TSH < 5.0 mU/mL. Patients with further categorized untreated 193),...
Glucagon-like peptide-1 (GLP-1) is an incretin hormone that regulates glucose homeostasis. Because of their direct stimulation insulin secretion from pancreatic β cells, GLP-1 receptor (GLP-1R) agonists are now important therapeutic options for the treatment type 2 diabetes. To better understand mechanisms control insulinotropic actions GLP-1, affinity purification and mass spectrometry (AP-MS) were employed to uncover potential proteins functionally interact with GLP-1R. AP-MS performed on...
Background: Recent studies show that microRNA-145 (miRNA-145) might be an attractive tumor biomarker of considerable prognostic value, but little is known about their relationship with acute myocardial infarction (AMI). This study investigated the correlation between level miR-145 and AMI. Methods: One-hundred patients were divided into three groups: no coronary artery disease (CAD) group, non-ST segment elevation ST group. The plasma levels quantified using real-time quantitative polymerase...
Background To better understand the pathogenesis of cervical cancer (CC), we systematically analysed genomic variation and human papillomavirus (HPV) integration profiles intraepithelial neoplasia (CIN) CC. Methods We performed whole-genome sequencing or whole-exome 102 tumour-normal pairs probe capture 45 CCs, 44 CIN samples 25 normal samples, constructed strict integrated workflow analysis. Results Mutational analysis identified eight significantly mutated genes in CC including four ( FAT1...
Background Hypothyroidism is associated with an increased risk of coronary artery disease, beyond that which can be explained by its association conventional cardiovascular factors. Coronary endothelial dysfunction precedes atherosclerosis, has been linked to adverse events, and may account for some the in patients hypothyroidism. The aim this study was determine whether there between epicardial microvascular Methods Results In 1388 (mean age 50.5 [12.3] years, 34% male) presenting stable...
Resveratrol is a natural plant polyphenol. The present study investigated the effects of resveratrol on Toll-like receptor 4- (TLR4-) mediated expression and secretion matrix metalloproteinases (MMPs) in oxidized low-density lipoprotein- (ox-LDL-) treated human umbilical vein endothelial cells (HUVECs). Protein was analyzed by immunoblotting. MMPs measured an enzyme-linked immunosorbent assay. animal experiments were performed with without treatment high-fat chow-fed mice. inhibited TLR4,...
Abstract Objectives The velocity vector imaging (VVI) technique is useful to assess regional myocardial mechanics. aim of this study was evaluate the usefulness technology in assessing right ventricular longitudinal functions fetus and establish a nomogram ventricle (RV). Methods We studied 170 healthy fetuses that were divided into five groups based on gestational age. Dynamic digital images four chambers collected analyzed off‐line. VVI parameters calculated free wall septum, respectively....
Sporotrichosis is a chronic fungal infection with global distribution; both sporadically occurring infections and outbreaks of cases are not uncommon. Sporothrix schenckii, as the causative agent, can be isolated from soil, wood, land, even marine animals. We present clinical histopathological presentations sporotrichosis collected in our department for about 40 years. A series interesting pictures illustrating asteroid bodies organism materials, which rarely seen, also showed. Asteroid body...
Liver cancer is one of the most common cancers worldwide. CDR3 sequencing-based immune repertoire can be closely associated with prognosis and development. Identifying specific interaction between TCR cellular antigens important for developing novel immunotherapeutic approaches treatment cancer. The rearranged TCRβ loci amplified using Vβ- Jβ-specific primers by multi-PCR sequenced high-throughput sequencing (HTS) in liver were compared those T cells from healthy adult peripheral blood...
Abstract The aim was to investigate the impact of maternal hyperoxygenation (HO) on cardiac dimensions in fetuses with isolated Coarctation (CoA). Fetal echocardiography performed serially 48 CoA and gestation age matched normal fetues. Z-scores for mitral valve (MV), tricuspid (TV), aortic (AV), ascending aorta (AAo), isthmus, pulmonary (PV), main artery (MPA), descending (DAo) were measured compared among fetuses, oxygen air. In group oxygen, 6 L/min administered mother using a face mask....