A5078936866- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Prenatal Screening and Diagnostics
- Genomic variations and chromosomal abnormalities
- Cancer Immunotherapy and Biomarkers
- Aortic Disease and Treatment Approaches
- Pulmonary Hypertension Research and Treatments
- Pain Mechanisms and Treatments
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Hemoglobinopathies and Related Disorders
- Transcranial Magnetic Stimulation Studies
- Extracellular vesicles in disease
- Aortic aneurysm repair treatments
- Transplantation: Methods and Outcomes
- Fibroblast Growth Factor Research
- Single-cell and spatial transcriptomics
- Electrospun Nanofibers in Biomedical Applications
- Cardiac Valve Diseases and Treatments
- Parvovirus B19 Infection Studies
- Microtubule and mitosis dynamics
- Neurological disorders and treatments
- Mesenchymal stem cell research
Qilu Hospital of Shandong University
2014-2025
Wuhan University
2017-2025
Lanzhou University
2013-2025
First Hospital of Lanzhou University
2025
NYU Langone Health
2020-2024
Guangdong Province Women and Children Hospital
2015-2024
Capital Medical University
2010-2024
Shihezi University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Institute of Hematology & Blood Diseases Hospital
2024
Background/Aims: Recent studies have shown that circulating microRNAs (miRNAs) are emerging as promising biomarkers for cardiovascular diseases. This study aimed to determine whether miR-19b-3p, miR-134-5p and miR-186-5p can be used novel indicators acute myocardial infarction (AMI). Methods: To investigate the kinetic expression of three selected miRNAs, we enrolled 18 patients with AMI 20 matched controls. Plasma samples were collected from each participant, total RNA was extracted....
Significance Noninvasive prenatal testing (NIPT) using sequencing of fetal cell-free DNA from maternal plasma has allowed accurate diagnosis aneuploidy without requirement an invasive procedure; this approach gained increasing clinical acceptance. In manuscript, we evaluate whether NIPT semiconductor platform (SSP) could reliably detect subchromosomal deletions/duplications in women carrying a high-risk fetus. We show that detection abnormalities is viable extension SSP. Given the recent...
Background/Aims: Hypoxia is a basic pathological challenge that associated with numerous cardiovascular disorders including aberrant cardiac remodeling. Transforming growth factor beta (TGF-β) signaling pathway plays pivotal role in mediating fibroblast (CF) function and fibrosis. Recent data suggested microRNA-101a (miR-101a) exerted anti-fibrotic effects post-infarct remodeling improved function. This study aimed to investigate the potential relationship between hypoxia, miR-101a TGF-β...
Transcranial direct current stimulation (tDCS) has been explored in epilepsy with limited samples, varied parameters, and inconclusive results. We aimed to study the efficacy of tDCS for patients refractory focal epilepsy.We conducted a randomized, double-blind, sham-controlled, three-arm (Group 1 (sham), Group 2 (20-min), 3 (2 × 20-min)) parallel multicenter study. The primary outcome measurement was seizure frequencies (SFs). consisted 28-days baseline, 14-days treatment, 56-days...
An aneuploid-immune paradox encompasses somatic copy-number alterations (SCNAs), unleashing a cytotoxic response in experimental precancer systems, while conversely being associated with immune suppression and cytotoxic-cell depletion human tumors, especially head neck cancer (HNSC). We present evidence from patient samples cell lines that chromosome dosage contribute to an hot-to-cold switch during papillomavirus-negative (HPV
Abstract Human cancer cell lines have long served as tools for research and drug discovery, but the presence source of intra-cell-line heterogeneity remain elusive. Here, we perform single-cell RNA-sequencing ATAC-sequencing on 42 39 human lines, respectively, to illustrate both transcriptomic epigenetic within individual lines. Our data reveal that is frequently observed in different tissue origins, often driven by multiple common transcriptional programs. Copy number variation, well...
Background: Coronary artery disease (CAD) is a major problem worldwide. As an endothelium-enriched microRNA (miRNA), miR-126 has been reported to serve as potential biomarker of acute myocardial infarction. However, the relationship between and severity CAD remains unknown. This study was designed test whether circulating levels are associated with CAD. Methods: The present enrolled 40 patients who had risk factors for without angiographically significant CAD, 110 presenting stable angina...
Abstract Chemotherapy-induced peripheral neuropathy is among the most common dose-limiting adverse effects of cancer treatment, leading to dose reduction and discontinuation life-saving chemotherapy a permanently impaired quality life for patients. Currently, no effective treatment or prevention available. Senescence induced during has been shown promote effects. Here, we show that cisplatin induces senescent-like neuronal cells in primary culture mouse dorsal root ganglia (DRG), as...
Background: Recent studies show that microRNA-145 (miRNA-145) might be an attractive tumor biomarker of considerable prognostic value, but little is known about their relationship with acute myocardial infarction (AMI). This study investigated the correlation between level miR-145 and AMI. Methods: One-hundred patients were divided into three groups: no coronary artery disease (CAD) group, non-ST segment elevation ST group. The plasma levels quantified using real-time quantitative polymerase...
Somatic copy number alterations (SCNAs), generally ( 1 ) losses containing interferons and interferon-pathway genes, many on chromosome 9p, predict immune-cold, immune checkpoint therapy (ICT)-resistant tumors 2 ); however, genomic regions mediating these effects are unclear probably tissue specific. Previously, 9p21.3 loss was found to be an early genetic driver of human papillomavirus–negative (HPV – head neck squamous cancer (HNSC), associated with immune-cold tumor microenvironment (TME)...
How cells control gene expression is a fundamental question. The relative contribution of protein-level and RNA-level regulation to this process remains unclear. Here, we perform proteogenomic analysis tumors untransformed containing somatic copy number alterations (SCNAs). By revealing how regulate RNA protein abundances genes with SCNAs, provide insights into the rules regulation. Protein complex have strong while non-complex Notable exceptions are plasma membrane genes, which show weak...
Hepatocellular carcinoma (HCC) is the most common liver cancer with a high rate of metastasis. However, molecular mechanisms that drive metastasis remain unclear. We combined single-cell transcriptomic, proteomic, and chromatin accessibility data to investigate how heterogeneous phenotypes contribute metastatic potential in five HCC cell lines. confirmed prevalence mesenchymal state levels proliferation are linked potential. also identified rare hypoxic subtype has higher capacity for...
Abstract Background Pulmonary arterial hypertension (PAH) is associated with oxidative stress and affects the survival homing of transplanted mesenchymal stem cells (MSCs) as well cytokine secretion by MSCs, thereby altering their therapeutic potential. In this study, we preconditioned MSCs prostaglandin E1 (PGE1) performed in vitro vivo cell experiments to evaluate effects rats PAH. Methods We studied relationship between PGE1 vascular endothelial growth factor (VEGF) secretion, B-cell...
Abstract The oxidative stress caused by endothelial injury is involved in intimal hyperplasia ( IH ) vein grafts. Mesenchymal stem cells MSC s) can home to injured intima and promote repair. However, apoptosis increased accompanied decreased functional activity under stress. Thus, we investigate whether tumour necrosis factor‐α TNF ‐α) the survival of s reduce more effectively, establish what role NF ‐κB pathway plays this. In this study, preconditioned with ‐α ‐α‐PC MSCs) for 24 hrs...
Pulmonary arterial hypertension (PAH) is a common and fatal complication of systemic lupus erythematosus (SLE). Whether the BMP receptor deficiency found in genetic form PAH also involved SLE-PAH patients remains to be identified. In this study, we employed patient-derived samples from SLE-associated (SLE-PAH) established comparable mouse models clarify role signaling pathobiology SLE-PAH. Firstly, serum levels LPS autoantibodies (auto-Abs) directed at receptors were significantly increased...
Background In the current study, we sought to characterise methylation haplotypes and nucleosome positioning patterns of placental DNA plasma cell-free pregnant women with early-onset preeclampsia using whole genome bisulphite sequencing (WGBS) capture (MCBS) further develop examine diagnostic performance a generalised linear model (GLM) by incorporating epigenetic features for preeclampsia.