A5073583133- Liver Disease Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Biosensors and Analytical Detection
- Drug Transport and Resistance Mechanisms
- Cancer-related gene regulation
- Metabolomics and Mass Spectrometry Studies
- Gut microbiota and health
- Advanced biosensing and bioanalysis techniques
- Diet, Metabolism, and Disease
- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Bacteriophages and microbial interactions
- Cancer Immunotherapy and Biomarkers
- Enzyme Production and Characterization
- Pharmacological Effects and Toxicity Studies
- Radical Photochemical Reactions
- Pharmacology and Obesity Treatment
- SARS-CoV-2 detection and testing
- CRISPR and Genetic Engineering
- Dendrimers and Hyperbranched Polymers
- Enzyme Structure and Function
- Extracellular vesicles in disease
- Tea Polyphenols and Effects
Shanghai Jiao Tong University
2008-2025
Guangdong Pharmaceutical University
2021-2025
First Affiliated Hospital of Guangdong Pharmaceutical University
2022-2024
Guangzhou Medical University
2019-2024
Shenzhen Second People's Hospital
2022-2024
Zhongnan Hospital of Wuhan University
2022-2023
Wuhan University
2022-2023
Anhui University of Traditional Chinese Medicine
2019-2023
Chongqing University
2022
China Pharmaceutical University
2015-2019
Metabolic dysfunction-associated steatohepatitis (MASH) is a complex disease driven by diverse metabolic and inflammatory pathways. Farnesoid X receptor (FXR) promising target for MASH due to its role in bile acid lipid metabolism, while HSD17B13 regulates liver droplet homeostasis. However, the existing inhibitors have several druglike property challenges common phenolic structure, key pharmacophore inhibitor. In this study, two-round high-throughput screening was performed identify FXR...
Background To better understand the pathogenesis of cervical cancer (CC), we systematically analysed genomic variation and human papillomavirus (HPV) integration profiles intraepithelial neoplasia (CIN) CC. Methods We performed whole-genome sequencing or whole-exome 102 tumour-normal pairs probe capture 45 CCs, 44 CIN samples 25 normal samples, constructed strict integrated workflow analysis. Results Mutational analysis identified eight significantly mutated genes in CC including four ( FAT1...
Carbon source is an important nutrient for bacteria to sustain growth and often acts as a signal that modulates virulence expression. L-arabinose produced by plants plays role in regulating the global gene expression of bacteria. Previously, we have shown induces more severe systemic infection Salmonella-infected mice with normal microbiota, but does not affect disease progression microbiota depleted antibiotic treatment. The underlying mechanism remains elusive. In this study, demonstrate...
Liver cancer is one of the most common cancers worldwide. CDR3 sequencing-based immune repertoire can be closely associated with prognosis and development. Identifying specific interaction between TCR cellular antigens important for developing novel immunotherapeutic approaches treatment cancer. The rearranged TCRβ loci amplified using Vβ- Jβ-specific primers by multi-PCR sequenced high-throughput sequencing (HTS) in liver were compared those T cells from healthy adult peripheral blood...
The prevalence of nonalcoholic steatohepatitis (NASH) is increasing rapidly worldwide, and NASH has become a serious problem for human health. Recently, the selective activation intestinal farnesoid X receptor (FXR) was considered as more promising strategy treatment with lesser side effects due to reduced systemic exposure. Moreover, inhibition fatty acid binding protein 1 (FABP1) alleviated obesity by reducing dietary uptake. In this study, first-in-class restricted FXR FABP1 dual-target...
The identification of potential oncogenes plays an important role in finding novel therapeutic targets for many cancers, including hepatocellular carcinoma (HCC), which is one the most common cancers worldwide. In our previous research, using microarray technology, we found that FAM83D was overexpressed HCCs. However, whether overexpression contributes to hepatocarcinogenesis remains unclear. this study, significantly upregulated 76.6% (167 218) HCC specimens at mRNA level and 69.44% (50 72)...
Aldehyde dehydrogenase 5 family, member A1 (ALDH5A1) belongs to the superfamily of aldehyde dehydrogenases (ALDHs). However, prognostic value ALDH5A1 in ovarian cancer remains unclear. The aim this study was explore relationship between and prognosis patients with (OC). We compared expression OC that innormal controls, using GSE40595 profiling data. Tissue microarray analysis conducted for192 patients, 14 adjacent normal ovary tissues, 2 tissues. Using "Kaplan-Meier plotter" (KM plotter)...
Abstract Nephrotoxicity has long been the most severe and life-threatening side-effect of cisplatin, whose anticancer effect is therefore restricted. Previous pathological studies have shown that both renal cortex medulla could be injured by cisplatin. Our TUNEL (terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling) assay results further uncovered subjected more injury than cortex. In order to depict underlying metabolic mechanism spatial difference in response present...
Fam134b (JK‐1, RETREG1) was first identified as an oncogene in esophageal squamous cell carcinoma. However, the roles of FAM 134B during tumorigenesis hepatocellular carcinoma ( HCC ) and epithelial‐to‐mesenchymal transition EMT were previously unclear. In this study, we investigated function related mechanisms, well how induces . We detected expression a normal hepatic line, lines, fresh specimens, tissue microarray. A retrospective study 122 paired microarrays used to analyze correlation...
To explore the positivity rate and genotype distribution of human papillomavirus (HPV) in cervical squamous cell carcinoma (CSCC) tissues central eastern China to provide theoretical basis for cancer screening prophylactic HPV vaccine development China. DNA was extracted from paraffin-embedded CSCC samples exfoliated cells populations. 23 genotypes were detected by combining polymerase chain reaction (PCR) reverse dot hybridized gene chip detection technology 2,306 10,245 The infection...
Abstract Neuroinflammation is one of the driving forces progressive neurodegeneration in Parkinson’s disease (PD). The metabolomics approach has been proved highly useful identifying potential therapeutic targets. Here, to identify inflammation‐relevant treatment targets for PD, mass spectrometry‐based untargeted was applied characterize metabolic changes striatum mice with double‐hit PD induced by lipopolysaccharide plus 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP). Seven days after...
DndABCDE-catalyzed DNA phosphorothioation (PT), in which the nonbridging oxygen is swapped with a sulfur atom, was first identified bacterial genome. Usually, this modification gene cluster paired restriction module consisting of DndF, DndG, and DndH. Although mechanisms for antiphage activity conferred by Dnd-related (R-M) system have been well characterized, several features remain unclear, including spectrum potential interference methylation. Recently, novel PT-related R-M system,...
The gut microbiota is essential for providing colonization resistance against pathogens. Dietary sugars markedly shift the composition of intestinal and alter host susceptibility to enteric infections. Here, we demonstrate effect L-arabinose on bacterial infection by using a mouse model with