A5103197085- Viral-associated cancers and disorders
- Liver Disease Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Cytomegalovirus and herpesvirus research
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Pharmacogenetics and Drug Metabolism
- RNA modifications and cancer
- Mitochondrial Function and Pathology
- Financial Markets and Investment Strategies
- Vibrio bacteria research studies
- Salmonella and Campylobacter epidemiology
- Drug Transport and Resistance Mechanisms
- Antibiotic Resistance in Bacteria
- Neonatal Health and Biochemistry
- Drug-Induced Hepatotoxicity and Protection
- Heme Oxygenase-1 and Carbon Monoxide
- Pancreatic function and diabetes
- Lymphoma Diagnosis and Treatment
- Histiocytic Disorders and Treatments
- Endoplasmic Reticulum Stress and Disease
- Epigenetics and DNA Methylation
- Hippo pathway signaling and YAP/TAZ
- Ubiquitin and proteasome pathways
- PI3K/AKT/mTOR signaling in cancer
Shanghai Jiao Tong University
2016-2025
Ruijin Hospital
2016-2025
First Affiliated Hospital of Zhengzhou University
2025
Sanya University
2025
Hainan University
2024-2025
Dali University
2025
University of Pittsburgh
2013-2024
The University of Melbourne
2024
Children's Hospital of Pittsburgh
2014-2024
Fudan University
2023-2024
Epstein-Barr virus (EBV), etiologically linked with human B-cell malignancies and nasopharyngeal carcinoma (NPC), establishes three types of latency that facilitate its episomal genome persistence evasion host immune responses. The innate inflammasome responses recognize the pathogen-associated molecular patterns which lead into association a cytoplasmic sensor such as NLRP3 AIM2 proteins or nuclear interferon-inducible protein 16 (IFI16) adaptor ASC (apoptosis-associated speck-like caspase...
The two-component system PhoP-PhoQ is highly conserved in bacteria and regulates virulence response to various signals for within the mammalian host. Here, we demonstrate that PhoP could be acetylated by Pat deacetylated deacetylase CobB enzymatically vitro vivo Salmonella Typhimurium. Specifically, lysine residue 201(K201) winged helix–turn–helix motif at C-terminal DNA-binding domain of acetylated, its acetylation level decreases dramatically when encounter low magnesium, acid stress or...
Enterohemorrhagic Escherichia coli (EHEC) is one major type of contagious and foodborne pathogens. The VI secretion system (T6SS) has been shown to be involved in the bacterial pathogenicity bacteria-bacteria competition. Here, we show that EHEC could secrete a novel effector KatN, Mn-containing catalase, T6SS-dependent manner. Expression katN promoted by RpoS OxyR repressed H-NS, contributes growth under oxidative stress vitro. KatN secreted into host cell cytosol after phagocytized...
SIRT5 is a lysine desuccinylase known to regulate mitochondrial fatty acid oxidation and the urea cycle. Here, was observed bind cardiolipin via an amphipathic helix on its N terminus. In vitro, succinyl-CoA used succinylate liver membrane proteins. largely reversed succinyl-CoA-driven succinylation. Quantitative mass spectrometry of SIRT5-treated proteins pointed electron transport chain, particularly Complex I, as being highly targeted for desuccinylation by SIRT5. Correspondingly,...
Epstein-Barr virus (EBV) is linked to a broad spectrum of B-cell malignancies. EBV nuclear antigen 3C (EBNA3C) an encoded latent required for growth transformation primary human B-lymphocytes. Interferon regulatory factor 4 (IRF4) and 8 (IRF8) are transcription factors the IRF family that regulate diverse functions in B cell development. IRF4 oncoprotein with anti-apoptotic properties IRF8 as regulator apoptosis tumor suppressor many hematopoietic We now demonstrate EBNA3C can contribute by...
Thrombospondin type-I domain-containing 7A (THSD7A) was recently identified as the target antigen in about 10% of patients with M-type phospholipase A2 receptor (PLA2R)-negative membranous nephropathy European and North American populations. The prevalence THSD7A other populations their clinical associations deserve further clarification.Immunofluorescence assay performed to investigate anti-THSD7A antibodies 578 consecutive biopsy-proven idiopathic nephropathy, 114 secondary 64 disease...
Salmonella causes a range of diseases in different hosts, including enterocolitis and systemic infection. Lysine acetylation regulates many eukaryotic cellular processes, but its function bacteria is largely unexplored. The acetyltransferase Pat NAD+-dependent deacetylase CobB are involved the reversible protein Typhimurium. Here, we used cell animal models to evaluate virulence pat cobB deletion mutants S. Typhimurium found that critical for bacterial intestinal colonization Next,...
MYC proto-oncogene dysregulation alters metabolism, translation, and other functions in ways that support tumor induction maintenance. Although Myc+/- mice are healthier longer-lived than control mice, the long-term ramifications of more complete Myc loss remain unknown. We now describe chronic consequences body-wide inactivation initiated postnatally. "MycKO" acquire numerous features premature aging, including altered body composition habitus, metabolic dysfunction, hepatic steatosis, gene...
EBNA3C, one of the Epstein-Barr virus (EBV)-encoded latent antigens, is essential for primary B-cell transformation. Cyclin D1, a key regulator G1 to S phase progression, tightly associated and aberrantly expressed in numerous human cancers. Previously, EBNA3C was shown bind D1 vitro along with A E. In present study, we provide evidence which demonstrates that forms complex cells. Detailed mapping experiments show small N-terminal region lies between amino acids 130–160 binds two different...
A predominant pathway of xenobiotic-induced toxicity is initiated by bioactivation. Characterizing reactive intermediates will provide information on the structure species, thereby defining a potential bioactivation mechanism. Because most metabolites are not stable, it difficult to detect them directly. Reactive can form adducts with trapping reagents, such as glutathione, which makes detectable. However, challenging "fish" these out from complex biological matrix, especially for generated...
The Epstein-Barr nuclear antigen 3C (EBNA3C), one of the essential latent antigens for virus (EBV)-induced immortalization primary human B lymphocytes in vitro, has been implicated regulating cell proliferation and anti-apoptosis via interaction with several cellular viral factors. Gemin3 (also named DDX20 or DP103) is a member DEAD RNA helicase family which exhibits diverse functions including DNA transcription, recombination repair, metabolism. was initially identified as binding partner...
Gammaherpesviruses human herpesvirus 4 (HHV4) and HHV8 are two prominent members of the family associated with a number cancers. HHV4, also known as Epstein-Barr virus (EBV), ubiquitous gammaherpesvirus prevalent in 90 to 95% population, is clinically various neurological diseases such primary central nervous system lymphoma, multiple sclerosis, Alzheimer's disease, cerebellar ataxia, encephalitis. However, possibility that EBV Kaposi's sarcoma-associated (KSHV) can directly infect neurons...
The ability to acetylate lysine residues is conserved across organisms, and acetylation of plays important roles in various cellular functions. Maintaining intracellular pH homeostasis crucial for the survival enteric bacteria acidic gastric tract. It has been shown that eukaryotes can stabilize by histone deacetylation. However, it remains unknown whether utilize a reversible protein system adapt an environment. Here we demonstrate acetylation/deacetylation critical Salmonella enterica...
Abstract The regulation of chromosomal replication is critical and the activation DnaA by ATP binding a key step in initiation. However, it remains unclear whether how process ATP-binding to regulated. Here, we show that can be acetylated its acetylation level varies with cell growth correlates DNA initiation frequencies E. coli . Specifically, conserved K178 Walker A motif reaches summit at stationary phase, which prevents from or oriC leads inhibition deacetylation catalyzed deacetylase...
Acute or acute-on-chronic liver failure is a leading cause of death in diseases without effective treatment. Interleukin-22 (IL-22) currently clinical trials for the treatment severe alcoholic hepatitis, but underlying mechanisms remain to be explored. Autophagy plays critical role alleviating injury. The aim current study explore autophagy IL-22-mediated hepato-protective effect against acetaminophen (APAP)-induced Methods: A model acute injury induced by APAP was used vivo. IL-22...
Recent studies have shown that microRNAs, a class of small and noncoding RNA molecules, play crucial roles in the initiation progression pancreatic cancer. In present study, expression miR-191 were investigated. Through both gain-of function loss-of experiments, pro-oncogenic was demonstrated. At molecular level, bioinformatic prediction, luciferase, protein analysis suggested could inhibit levels UPS10, which suppressed proliferation growth cancer cells through stabilizing P53 protein....