A5011767765- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Immune Cell Function and Interaction
- HIV/AIDS drug development and treatment
- Liver Disease and Transplantation
- Hepatitis Viruses Studies and Epidemiology
- Liver Diseases and Immunity
- Monoclonal and Polyclonal Antibodies Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver physiology and pathology
- Systemic Lupus Erythematosus Research
- Alcohol Consumption and Health Effects
- Drug Transport and Resistance Mechanisms
- interferon and immune responses
- MicroRNA in disease regulation
- Viral gastroenteritis research and epidemiology
- Drug-Induced Hepatotoxicity and Protection
- Immunotherapy and Immune Responses
- Cytomegalovirus and herpesvirus research
- SARS-CoV-2 and COVID-19 Research
- HIV Research and Treatment
- Chronic Lymphocytic Leukemia Research
- Organ Transplantation Techniques and Outcomes
- Diabetes and associated disorders
Jilin University
2016-2025
First Hospital of Jilin University
2016-2025
The Affiliated Hospital to Changchun University of Chinese Medicine
2013-2024
Guangxi University
2013-2024
GlaxoSmithKline (India)
2024
Yulin Normal University
2019-2024
Guangxi Academy of Agricultural Science
2014-2024
Southern Medical University
2012-2024
Nanfang Hospital
2007-2024
China Agricultural University
2024
Background & AimsWe performed a nationwide, retrospective study to determine the incidence and causes of drug-induced liver injury (DILI) in mainland China.MethodsWe collected data on total 25,927 confirmed DILI cases, hospitalized from 2012 through 2014 at 308 medical centers China. We demographic, history, treatment, laboratory, disease severity, mortality all patients. Investigators each site were asked complete causality assessments for case whose diagnosis discharge was (n = 29,478)...
Hepatocellular carcinoma (HCC) is the third most lethal cancer worldwide. The lack of effective biomarkers for early detection HCC results in unsatisfactory curative treatments. Here, metabolite were identified and validated diagnosis. A total 1,448 subjects, including healthy controls patients with chronic hepatitis B virus infection, liver cirrhosis, HCC, recruited from multiple centers China. Liquid chromatography–mass spectrometry–based metabolomics methods used to characterize subjects'...
•In total, 17,374 patients with viral and non-viral hepatitis from 11 global prospective cohorts/trials were studied.•An HCC risk score (called the aMAP score, ranging 0 to 100), which involves only age, male, albumin–bilirubin platelet data, was developed validated.•The had excellent discrimination calibration in assessing 5-year irrespective of aetiology ethnicity.•Patients <50, accounting for 44% overall population, an incidence <0.2% per year. Background & AimsHepatocellular carcinoma...
The mechanisms of chronic HBV infection and immunopathogenesis are poorly understood due to a lack robust small animal model. Here we report the development humanized mouse model with both human immune system liver cells by reconstituting immunodeficient A2/NSG (NOD.Cg-Prkdc(scid) Il2rg(tm1Wjl)/SzJ mice HLA-A2 transgene) hematopoietic stem progenitor (A2/NSG-hu HSC/Hep mice). A2/NSG-hu supported approximately 75% infected established persistent for at least 4 months. We detected responses,...
Chronic hepatitis B and its life-threatening sequelae are highly prevalent in China. There is a need for effective new therapies to suppress virus (HBV) replication ameliorate liver disease. In this study, we compared the efficacy of telbivudine, nucleoside analogue, with lamivudine Chinese patients. phase III, double-blind, multicenter trial conducted China, 332 patients compensated e antigen (HBeAg)–positive or HBeAg-negative chronic were randomly assigned treatment 600 mg telbivudine 100...
Methicillin (meticillin)-resistant Staphylococcus aureus (MRSA) is a serious problem worldwide. To investigate the molecular epidemiology of MRSA isolates in China, total 702 collected from 18 teaching hospitals 14 cities between 2005 and 2006 were characterized by antibiogram analysis, pulsed-field gel electrophoresis (PFGE), staphylococcal cassette chromosome mec (SCCmec) typing, spa typing; 102 selected for multilocus sequence typing (MLST). Overall, SCCmec type III was most popular found...
Abstract Exhaustion of cytotoxic effector natural killer (NK) and CD8 + T cells have important functions in the establishment persistent viral infections, but how exhaustion is induced during chronic hepatitis C virus (HCV) infection remains poorly defined. Here we show, using humanized C/O Tg mice permissive for HCV infection, that NK become sequentially exhausted shortly after their transient hepatic infiltration activation acute infection. upregulates Qa-1 expression hepatocytes, which...
HBV infection represents a major health problem worldwide, but the immunological mechanisms by which causes chronic persistent remain only partly understood. Recently, cell subsets with suppressive features have been recognised among monocytes and natural killer (NK) cells. Here we examine effects of on NK cells.Monocytes cells derived from HBV-infected patients healthy controls were purified characterised for phenotype, gene expression cytokines secretion flow cytometry, quantitative...
<h3>Objective</h3> The investigation regarding the clinical significance of quantitative hepatitis B core antibody (anti-HBc) during chronic (CHB) treatment is limited. aim this study was to determine performance anti-HBc as a predictor for e antigen (HBeAg) seroconversion in HBeAg-positive CHB patients treated with peginterferon (Peg-IFN) or nucleos(t)ide analogues (NUCs), respectively. <h3>Design</h3> This retrospective cohort consisting 231 and 560 enrolled two phase IV, multicentre,...
Chronic hepatitis C virus (HCV) infection is relatively frequent in China. This study investigated the clinical, demographic, and viral host genetic characteristics that may influence disease manifestations clinical management.In this cross-sectional observational study, treatment-naïve Han ethnic adults with recently confirmed chronic HCV were enrolled at 28 hospitals across genotype interleukin 28B (IL28B) genotypes determined compared patient demographic parameters medical status.Among...
Hepatocellular carcinoma (HCC) and liver cirrhosis are associated with high mortality worldwide. Currently, alpha-fetoprotein (AFP) is used as a standard serum marker for the detection of HCC, but its sensitivity specificity unsatisfactory, optimal diagnostic markers lacking. We previously reported that growth differentiation factor 15 (GDF15) was significantly induced in HCV-infected hepatocytes. This study aimed to investigate GDF15 expression correlation hepatitis virus-related diseases....
There is no satisfactory way to identify patients who will maintain a response after discontinuation of nuleos(t)ide analogue therapy for chronic hepatitis B virus (HBV) infection. We investigated whether with negative results from tests HBV DNA and RNA (double negative) at the end treatment long-term treatment.We performed post-hoc analysis data 2-year multi-center randomized controlled trial, its extension trials, on 130 infection were positive HB e antigen (HBeAg-positive; mean age, 30.8...
Infection with SARS-CoV-2, the causative agent of COVID-19, causes mild to moderate disease in most patients but carries a risk morbidity and mortality. Seriously affected individuals manifest disorders hemostasis cytokine storm, it is not understood how these manifestations severe COVID-19 are linked. Here, we showed that SARS-CoV-2 spike protein engaged CD42b receptor activate platelets via 2 distinct signaling pathways promoted platelet-monocyte communication through engagement P...
Abstract Background and aims Human umbilical cord mesenchymal stem cells (hUC-MSCs) are increasingly being studied in clinical trials of end-stage liver disease because their good tissue repair anti-inflammatory effects. hUC-MSC exosomes vesicles with spherical structures secreted by that produce them. The diameter is much smaller than hUC-MSCs, suggesting might be a novel safer therapeutic product cells. As have been suggested to biochemical functions similar those this study investigated...
Background The interleukin-28B gene (IL28B) locus has been associated with host resistance to hepatitis C virus (HCV) infection and response PEG-IFN/RBV treatment in western populations. This study was determine whether this variant is also spontaneous clearance of HCV infection, IL-28B protein production Chinese patients. Methods We genotyped IL28B genetic variations (rs12980275, rs8103142, rs8099917 rs12979860) by pyrosequencing DNA samples from cohorts consisting 529 subjects persistent...
Abstract Background: Recent genome‐wide association studies found that genetic polymorphisms near the IL28B gene is strongly associated with sustained viral response and spontaneous clearance in chronically infected hepatitis C patients. Aims: We aimed to evaluate effects of variations on B virus (HBV) infection a Chinese Han population explore between susceptibility infection, clearance, disease progression, load liver inflammation. Methods: determined three single ( rs12979860, rs12980275...
Elevated plasma levels of IL-1β and IL-18 from patients with hepatitis C virus (HCV) infection indicate a possible activation inflammasome by HCV.To demonstrate whether HCV activates the inflammasome, we investigated infected hepatic Huh7 cells, or monocytic cells THP-1 derived macrophages challenged virions, but no any was detected in these cells. However, when transfected genomic RNA into monocytes macrophages, secreted dose-dependent manner. We also ASC oligomerization caspase-1 cleavage...